Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder

Complex Psychiatry, Journal Year: 2025, Volume and Issue: 11(1), P. 1 - 11

Published: Feb. 13, 2025

Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals psychiatric illness. However, there is limited research those an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. Methods: We examined lifetime SA in 4,068 AUD from the Collaborative Study on Genetics Alcoholism (23% SA; 53% female; mean age: 38). explored for across other clinical conditions ascertained a interview, polygenic scores comorbid problems, and neurocognitive functioning. Results: Participants who attempted had greater trauma exposure, major depressive disorder, post-traumatic stress substance disorders (SUDs), suicidal ideation. Polygenic SA, depression, PTSD were increased odds reporting (ORs = 1.22–1.44). reported also decreased right hemispheric frontal-parietal theta interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative to did not, but differences small. Conclusions: Overall, report experience levels trauma, have more severe comorbidities, carry problems. Our results demonstrate need further investigate SAs presence SUDs.

Language: Английский

Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 29, 2023

Abstract Research has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals psychiatric illness. However, there is limited research those an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 DSM-IV dependence from the Collaborative Study on Genetics Alcoholism (23% attempt; 53% female; mean age: 38). Within participants AUD diagnosis, we explored risk across other clinical conditions, polygenic scores (PGS) for comorbid problems, neurocognitive functioning attempt. Participants who had attempted greater trauma exposure, major depressive disorder, post-traumatic stress substance disorders compared to not suicide. Polygenic attempt, depression, PTSD were reporting a attempt (ORs = 1.22 – 1.44). reported also decreased right hemispheric frontal-parietal theta interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative did not, but differences small. Overall, report appear experience levels trauma, have more severe comorbidities, carry variety problems. Our results demonstrate need further investigate presence disorders.

Language: Английский