Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study DOI Creative Commons
Chengcheng Tong,

Yufeng Xue,

Wei Wang

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 27, 2024

The process of biological aging in patients diagnosed with chronic liver disease remains unclear. current study aims to investigate if there is an accelerated participants advanced fibrosis (AF) and metabolic dysfunction-associated steatotic (MASLD). Data from the 2017-2018 NHANES cycle were analyzed. AF was determined based on values stiffness measurement (LSM) MASLD defined according new consensus nomenclature. Klemera-Doubal method age (KDM bioage) Phenotypic (Phenoage) adopted quantify age. Phenoage advancement (Phenoage_advance) KDM (KDM_advance) generated as difference between calculated chronological age, a positive residual regarded indicator aging. A total 3974 enrolled. weight mean KDM_advance phenoage_advance group 4.22 years (95%CI: 2.96-5.49 years) 2.61 1.80-3.41 years), while 0.37 -0.28-1.03 0.04 -0.64-0.72 respectively. Multivariate linear regression analysis showed that had older compared those without (1.50 0.23-2.77 P = 0.02; 1.00 0.18-1.82 respectively), models adjusting demographic characteristics, socioeconomic status, lifestyle factors, comorbidities. No significant association found phenoage_advance. AF, not MASLD, independently associated adults US representative sample.

Language: Английский

Changes in drinking levels and metabolic dysfunction-associated steatotic liver disease: a longitudinal study from the China multi-ethnic cohort study DOI Creative Commons
Ning Zhang, Jingzhong Li,

Xiaofen Xie

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 11, 2025

Little is known about the associations of changes in drinking levels with newly defined metabolic dysfunction-associated steatotic liver disease (MASLD). We therefore sought to estimate between and MASLD less developed regions China. This longitudinal study included 8727 participants from China Multi-Ethnic Cohort (CMEC) regions, all participating baseline a follow-up survey. was as hepatic steatosis, along presence at least one five cardiometabolic risks, addition limiting excessive alcohol consumption. applied parametric g-formula evaluate association MASLD. further estimated fibrosis scores (AST-to-platelet ratio fibrosis-4 index) patients Compared sustained non-drinking, modest associated higher risk (Mean Ratio (MR): 1.127 [95% CI: 1.040-1.242]). MR for those transitioning non-drinking 1.065 0.983-1.169], while changing 1.059 0.965, 1.173]. Non-invasive tended increase compared non-drinking. In China, moderate Increased showed trend towards can inform policies related regions.

Language: Английский

Citations

0
Environmental Health Is Overlooked in Longevity Research DOI Creative Commons
Robin Mesnage

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 421 - 421

Published: March 31, 2025

Aging is a multifactorial process influenced by genetic predisposition and lifestyle choices. Environmental exposures are too often overlooked. pollutants—ranging from airborne particulate matter heavy metals to endocrine disruptors microplastics—accelerate biological aging. Oxidative stress major molecular initiating event, driving inflammation toxicity across levels. We detail the mechanisms which pollutants enhance reactive oxygen species (ROS) production. This oxidative inflicts damage on DNA, proteins, lipids, accelerating telomere shortening, dysregulating autophagy, ultimately epigenetic age acceleration. For instance, exposure polycyclic aromatic hydrocarbons, benzene, pesticides has been associated with increased DNA methylation age. Early-life factors such as tobacco alcohol consumption further contribute accelerated The cumulative loss of healthy life years caused these can conceivably reach between 5 10 per person. Addressing pollutant-induced aging through regulatory measures, changes, therapeutic interventions essential mitigate their detrimental impacts, extending healthspan improving quality in populations.

Language: Английский

Citations

0
Associations of three healthy dietary patterns with homeostatic dysregulation: results from the China Multi-Ethnic Cohort study DOI Creative Commons

Hongmei Zhang,

Quzong Deji,

Ning Zhang

et al.

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(12), P. 100394 - 100394

Published: Oct. 17, 2024

Language: Английский

Citations

1
Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013–2016 DOI Creative Commons
Xinyun Chen,

Fangyu Shi,

Wenhui Yu

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 27, 2024

Population aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) widely used industrial chemical potential health risks, including associations age-related diseases. This study investigates relationship between EO exposure and biological age acceleration.

Language: Английский

Citations

0
Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study DOI Creative Commons
Chengcheng Tong,

Yufeng Xue,

Wei Wang

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 27, 2024

The process of biological aging in patients diagnosed with chronic liver disease remains unclear. current study aims to investigate if there is an accelerated participants advanced fibrosis (AF) and metabolic dysfunction-associated steatotic (MASLD). Data from the 2017-2018 NHANES cycle were analyzed. AF was determined based on values stiffness measurement (LSM) MASLD defined according new consensus nomenclature. Klemera-Doubal method age (KDM bioage) Phenotypic (Phenoage) adopted quantify age. Phenoage advancement (Phenoage_advance) KDM (KDM_advance) generated as difference between calculated chronological age, a positive residual regarded indicator aging. A total 3974 enrolled. weight mean KDM_advance phenoage_advance group 4.22 years (95%CI: 2.96-5.49 years) 2.61 1.80-3.41 years), while 0.37 -0.28-1.03 0.04 -0.64-0.72 respectively. Multivariate linear regression analysis showed that had older compared those without (1.50 0.23-2.77 P = 0.02; 1.00 0.18-1.82 respectively), models adjusting demographic characteristics, socioeconomic status, lifestyle factors, comorbidities. No significant association found phenoage_advance. AF, not MASLD, independently associated adults US representative sample.

Language: Английский

Citations

0