Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 DOI Creative Commons
Yan Fang,

Dajun Fang

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 25, 2024

Abstract Background Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women diagnosis adverse pregnancy outcomes. Methods A two-sample Mendelian randomization (MR) analysis in this study was used evaluate the casual relationships between infection obstetric-related diseases based on genome-wide association (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger MR-PRESSO were infer connection estimate pleiotropy respectively. Results The significant observed placental disorders beta IVW 1.57 odds ratio (OR) 4.81 (95% confidence interval [CI]: 1.05–22.05, p = 0.04). However, there no associations gestational diabetes mellitus (GDM) (OR 1.12; 95% CI: 0.85–1.45, 0.41), other amniotic fluid membranes 0.90; 0.61–1.32, 0.59), Intrahepatic Cholestasis Pregnancy (ICP) 1.42; 0.85–2.36, 0.18), birth weight 1.02; 0.99–1.05, 0.19), hypertension 1.00; 1.00–1.00, 0.85), spontaneous miscarriages 0.96–1.04, 0.90) stillbirth 0.98–1.01, 0.62). Conclusion There direct causal relationship maternal neonatal poor Our could alleviate anxiety under pandemic conditions partly.

Language: Английский

Updates on Auditory Outcomes of COVID-19 and Vaccine Side Effects: An Umbrella Review DOI Creative Commons
Zahra Jafari, Bryan Kolb, Steven J. Aiken

et al.

Journal of Speech Language and Hearing Research, Journal Year: 2025, Volume and Issue: 68(3), P. 1311 - 1332

Published: Feb. 21, 2025

This umbrella review synthesizes and discusses systematic reviews (SRs) meta-analyses (MAs) on auditory outcomes associated with COVID-19 infection vaccination side effects. It is innovative in offering a comprehensive synthesis of evidence across adults infants while summarizing vaccine-related literature search followed the Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines, no restrictions population age or symptom severity. Four electronic databases were searched from their inception to October 2024. The Assessment Multiple 2 checklist Risk Bias tool used assess quality risk bias. identified 534 articles, narrowed down 14 SRs following full-text review: Nine focused COVID-19; two, born mothers infected during pregnancy; three, effects vaccination. A random-effects model revealed significantly high pooled estimates hearing loss (5.0%, 95% CI [1.0, 9.0], p < .012, three MAs, N = 21,932) tinnitus (13.5%, [5.9, 21.1], ≤ .001, four 36,236) adults. However, current nonhospitalized patients indicates that symptoms often improve after recovery. Studies also show low rate whose contracted pregnancy. Similarly, whereas has been linked tinnitus, these are rare, most experience improvement within weeks months. Evidence suggests adults, although remain rare newborns caution warranted due limitations variability studies.

Language: Английский

Citations

0

Effects of Early-Life Air Pollution Exposure on Childhood COVID-19 Infection and Sequelae in China DOI
Chan Lu,

Wen Deng,

Zipeng Qiao

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137940 - 137940

Published: March 1, 2025

Language: Английский

Citations

0

The COVID-19 stress may influence on the sex ratio at birth DOI
Amir Abdoli

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2020, Volume and Issue: 35(21), P. 4043 - 4048

Published: Nov. 12, 2020

The ratio of boys to girls (sex ratio) at birth (SRB) is about 1.01–1.05 in most populations and influenced by various factors, such as maternal stress, inflammation, endocrine disruption. Male fetus biologically weaker more vulnerable prenatal events than female fetuses. Hence, premature death (and consequently decline the SRB) higher girls. recent coronavirus disease 2019 (COVID-19) has been known have a variety stressful psychological impacts. This stress may enhance pregnancy complication, fetal loss. Also, male fetuses adverse outcomes among asymptomatic pregnant women with SARS-Cov-2 infection. Inasmuch are death, it proposed that SRB can following COVID-19 stress. However, future studies needed define impact on rate.

Language: Английский

Citations

25

Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis DOI Open Access

Gordana Grgić,

Anis Cerovac, Igor Hudić

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(9), P. 1480 - 1480

Published: Sept. 9, 2022

This retrospective cohort study aimed to analyze the clinical manifestations, complications, and maternal-fetal outcomes in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery. The included 61 pregnant women positive for SARS-CoV-2 at time of Patients were divided into two groups: symptomatic asymptomatic. We found a significantly higher rate leukocytosis (p < 0.00078) lymphopenia 0.0024) compared with asymptomatic ones. Other laboratory parameters, such as CRP = 0.002), AST 0.007), LDH 0.0142), ferritin 0.0036), D-dimer 0.00124), also more often increased group women. Overall, delivery show altered parameters ones; nevertheless, they have slightly but non-significant preterm delivery, cesarean section, well lower neonatal birth weight Apgar score,

Language: Английский

Citations

16

Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 DOI Creative Commons
Yan Fang,

Dajun Fang

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 25, 2024

Abstract Background Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women diagnosis adverse pregnancy outcomes. Methods A two-sample Mendelian randomization (MR) analysis in this study was used evaluate the casual relationships between infection obstetric-related diseases based on genome-wide association (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger MR-PRESSO were infer connection estimate pleiotropy respectively. Results The significant observed placental disorders beta IVW 1.57 odds ratio (OR) 4.81 (95% confidence interval [CI]: 1.05–22.05, p = 0.04). However, there no associations gestational diabetes mellitus (GDM) (OR 1.12; 95% CI: 0.85–1.45, 0.41), other amniotic fluid membranes 0.90; 0.61–1.32, 0.59), Intrahepatic Cholestasis Pregnancy (ICP) 1.42; 0.85–2.36, 0.18), birth weight 1.02; 0.99–1.05, 0.19), hypertension 1.00; 1.00–1.00, 0.85), spontaneous miscarriages 0.96–1.04, 0.90) stillbirth 0.98–1.01, 0.62). Conclusion There direct causal relationship maternal neonatal poor Our could alleviate anxiety under pandemic conditions partly.

Language: Английский

Citations

3