The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis DOI Creative Commons
Zeynep Çelebi Sözener, Ümüş Özbey Yücel, Seda Altıner

et al.

Frontiers in Allergy, Journal Year: 2022, Volume and Issue: 3

Published: July 8, 2022

Introduction In the last decades, we have seen a rapid increase in prevalence of allergic diseases such as asthma, rhinitis, atopic dermatitis, and food allergies. The environmental changes caused by industrialization, urbanization modernization, including dramatic increases air pollutants particulate matter (PM), diesel exhaust, nitrogen dioxide (NO2), ozone (O3), alarming effects global warming, change loss biodiversity, affect both human health entire ecosystem. Objective this review, aimed to discuss external exposome on epithelial barriers its relationship with development considering all stakeholders outer together, light recently proposed barrier hypothesis. Method To reach current, prominent, comprehensive studies subject, PubMed databases were searched. We included more resounding articles reliable strong results. Results Exposure altered factors increased pollution, microplastics, nanoparticles, tobacco smoke, emulsifiers, detergents, household cleaners, climate change, microbial modifications consumption dietary fatty acids, use preservatives decrease antioxidant content widely consumed western diet may disrupt skin, respiratory gastrointestinal tracts, making us vulnerable exogeneous allergens microbes. Epithelial cell activation, dysbiosis bacterial translocation immune balance chronic Th2 inflammation ensues. Conclusion Dramatic worrisome dysbiosis, changing habits complex interactions these local systemic inflammation. want draw attention emerging motivate public influence government policies for well-being humans nature earth future generations.

Language: Английский

Captivity and Animal Microbiomes: Potential Roles of Microbiota for Influencing Animal Conservation DOI
Jason Dallas, Robin W. Warne

Microbial Ecology, Journal Year: 2022, Volume and Issue: 85(3), P. 820 - 838

Published: March 22, 2022

Language: Английский

Citations

77
Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients DOI Creative Commons
Ruoyun Xiong, Courtney Gunter, Elizabeth Fleming

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(2), P. 273 - 287.e5

Published: Feb. 1, 2023

Language: Английский

Citations

61
Microbiome Interconnectedness throughout Environments with Major Consequences for Healthy People and a Healthy Planet DOI
Angela Sessitsch, Steven A. Wakelin, Michael Schloter

et al.

Microbiology and Molecular Biology Reviews, Journal Year: 2023, Volume and Issue: 87(3)

Published: June 27, 2023

Microbiomes have highly important roles for ecosystem functioning and carry out key functions that support planetary health, including nutrient cycling, climate regulation, water filtration. are also intimately associated with complex multicellular organisms such as humans, other animals, plants, insects perform crucial the health of their hosts. Although we starting to understand microbiomes in different systems interconnected, there is still a poor understanding microbiome transfer connectivity. In this review show how connected within transferred between habitats discuss functional consequences these connections. Microbiome occurs abiotic (e.g., air, soil, water) biotic environments, can either be mediated through vectors or food) direct interactions. Such processes may include transmission pathogens antibiotic resistance genes. However, here, highlight fact positive effects on human where transmitted microorganisms potentially providing novel adaptation ecosystems.

Language: Английский

Citations

52
Biodiversity and human health: A scoping review and examples of underrepresented linkages DOI Creative Commons
Jake M. Robinson, Andrew C. Breed,

Araceli Camargo

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 246, P. 118115 - 118115

Published: Jan. 9, 2024

Mounting evidence supports the connections between exposure to environmental typologies––such as green spaces––and human health. However, mechanistic links that connect biodiversity (the variety of life) and health, extent supporting remain less clear. Here, we undertook a scoping review map health summarise levels associated using an established weight framework. Distinct from other reviews, provide additional context regarding environment-microbiome-health axis, evaluate buffering pathway (e.g., impacts on air pollution), examples three under- or minimally-represented linkages. The are (1) Indigenous Peoples' (2) urban social equity, (3) COVID-19. We observed moderate level support microbiota-human moderate-high broader nature pathways greenspace) various outcomes, stress reduction enhanced wellbeing improved cohesion. studies did not typically include specific metrics, indicating clear research gaps. Further is required understand causative metrics such taxonomy, diversity/richness, structure, function) outcomes. There well-established frameworks assess effects broad classifications These can assist future in linking Our underrepresented linkages highlight roles its loss lived experiences, infectious diseases, sovereignty livelihoods. More awareness these socioecological interconnections needed.

Language: Английский

Citations

25
Atopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review DOI
Shahnawaz Mohammad, Md Rezaul Karim, Safia Iqbal

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 281, P. 127595 - 127595

Published: Jan. 3, 2024

Language: Английский

Citations

19
Current and future threats to human health in the Anthropocene DOI Creative Commons
Shilu Tong, Hilary Bambrick, Paul J. Beggs

et al.

Environment International, Journal Year: 2021, Volume and Issue: 158, P. 106892 - 106892

Published: Sept. 27, 2021

It has been widely recognised that the threats to human health from global environmental changes (GECs) are increasing in Anthropocene epoch, and urgent actions required tackle these pressing challenges. A scoping review was conducted provide an overview of nine planetary boundaries population posed by activities exceeding Anthropocene. The research progress key knowledge gaps were identified this emerging field. Over past three decades, there a great deal on risks climate change, land-use change urbanisation, biodiversity loss other GECs. However, several significant challenges remain, including misperception relationship between nature; assessment compounding GECs; strategies reduce prevent potential impacts uncertainties fulfilling commitments Paris Agreement. Confronting will require rigorous scientific is well-coordinated across different disciplines various sectors. imperative for international community work together develop informed policies avert crises ensure safe sustainable planet present future generations.

Language: Английский

Citations

99
Microbiome and skin biology DOI

Nonhlanhla Lunjani,

Carol Hlela, Liam O’Mahony

et al.

Current Opinion in Allergy and Clinical Immunology, Journal Year: 2019, Volume and Issue: 19(4), P. 328 - 333

Published: May 17, 2019

The skin is home to a diverse milieu of bacteria, fungi, viruses, bacteriophages, and archaeal communities. application culture-independent approaches has revolutionized the characterization microbiome have revealed previously underappreciated phylogenetic functional granularity skin-associated microbes in both health disease states.The physiology given skin-niche drives site-specific differences bacterial phyla composition healthy skin. Changes consistently been associated with atopic dermatitis. In particular, Staphylococcus aureus overgrowth concomitant decline epidermidis general feature dermatitis not restricted eczematous lesions. fungal species are now also being described. metabolic activity gut microbiota health.We beginning appreciate intimate intricate interactions between health. Multiple studies currently focused on manipulation or explore their therapeutic potential prevention treatment inflammation.

Language: Английский

Citations

84
Effects of forest bathing (shinrin-yoku) on individual well-being: an umbrella review DOI
Michele Antonelli, Davide Donelli,

Lucrezia Carlone

et al.

International Journal of Environmental Health Research, Journal Year: 2021, Volume and Issue: 32(8), P. 1842 - 1867

Published: April 28, 2021

The aim of this review was to outline the most relevant benefits forest bathing for well-being promotion. This study designed as an umbrella literature review. Medline (via PubMed), EMBASE, Web Science, Cochrane Library, Google Scholar, Scopus, PsycINFO, CINAHL and DOAJ were systematically searched reviews up February 2021. After article selection, 16 systematic met inclusion criteria. Overall, best available evidence supports use a complementary practice promotion psychophysical well-being, whereas its therapeutic improvement organic diseases needs grow before clear specific clinical indications can be formulated. positive impact on individual quality life, along with favorable cost-effectiveness profile, may justify possible adoption public health strategies Further investigations topic are advised.

Language: Английский

Citations

69
Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children DOI Creative Commons
Marja I. Roslund, Riikka Puhakka, Noora Nurminen

et al.

Environment International, Journal Year: 2021, Volume and Issue: 157, P. 106811 - 106811

Published: Aug. 14, 2021

In modern urban environments children have a high incidence of inflammatory disorders, including allergies, asthma, and type 1 diabetes. The underlying cause these according to the biodiversity hypothesis, is an imbalance in immune regulation caused by weak interaction with environmental microbes. this 2-year study, we analyzed bacterial community shifts soil surface day-care centers commensal bacteria inhabiting mouth, skin, gut children. We compared two different environments: standard intervention centers. Yards latter were amended biodiverse forest floor vegetation sod at beginning study. Intervention long-standing increase relative abundance nonpathogenic mycobacteria soils. Treatment-specific became evident composition Gammaproteobacteria, Negativicutes, Bacilli, which jointly accounted for almost 40 50% taxa on children's skin saliva, respectively. year-one swabs, richness Alpha-, Beta-, Gammaproteobacteria was higher, potentially pathogenic bacteria, Haemophilus parainfluenzae, Streptococcus sp., Veillonella lower among gut, Clostridium sensu stricto decreased, particularly This study shows that shapes human microbiota, been associated regulation. Results indicate enriched microbiota suppressed skin. recommend future studies expand strategies response eventually immune-mediated diseases.

Language: Английский

Citations

66
The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate DOI Creative Commons
Holger Garn, Daniel P. Potaczek,

Petra Ina Pfefferle

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: March 18, 2021

During its 30 years history, the Hygiene Hypothesis has shown itself to be adaptable whenever it been challenged by new scientific developments and this is a still continuously ongoing process. In regard, mini review aims discuss some selected in relation their impact on further fine-tuning expansion of Hypothesis. This will include role recently discovered classes innate adaptive immune cells that challenges old Th1/Th2 paradigm, applicability newly identified allergy/asthma phenotypes with diverse underlying pathomechanistic endotypes, increasing knowledge derived from epigenetic studies leads better understanding mechanisms involved translation environmental impacts biological systems. Further, we brief other disease areas like psychiatric disorders cancer conclude developing may provide more generalized explanation for health burden highly industrialized countries also global changes.

Language: Английский

Citations

62