Bioactive lipids in the skin barrier mediate its functionality in health and disease

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 260, P. 108681 - 108681

Published: June 17, 2024

Our skin protects us from external threats including ultraviolet radiation, pathogens and chemicals, prevents excessive trans-epidermal water loss. These varied activities are reliant on a vast array of lipids, many which unique to skin, that support physical, microbiological immunological barriers. The cutaneous physical barrier is dependent specific lipid matrix surrounds terminally-differentiated keratinocytes in the stratum corneum. Sebum- keratinocyte-derived lipids cover skin's surface regulate microbiota. Meanwhile, signal between resident infiltrating immune cells, driving inflammation its resolution response other threats. Lipids particular importance include ceramides, crucial for corneum formation therefore functionality, fatty acids, contribute acidic pH microbiota, as well matrix, bioactive metabolites these involved cell signalling, inflammation, numerous processes. diverse complex maintain homeostasis healthy implicated diseases, unrelated systemic conditions with manifestations, processes such ageing. also gut-skin axis, signalling two sites. Therefore, provide valuable resource exploration processes, local disease development progression, accessible biomarker discovery disease, an opportunity fully understand relationship host Investigation could diagnostic prognostic biomarkers, help identify new targets interventions. Development improvement existing vitro silico approaches explore lipidome, advances lipidomics technologies, will facilitate ongoing progress research.

Language: Английский

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Longitudinal integrated proteomic and metabolomic skin changes in atopic dermatitis patients treated with dupilumab

Journal of Allergy and Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Ceramides and Skin Health: New Insights

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(2)

Published: Feb. 1, 2025

ABSTRACT Ceramide has transitioned from an incidental discovery to a vital element in skincare, becoming thoroughly studied compound the quest treat skin conditions. Creating moisture barrier, preserving hydration, regulating pH, controlling inflammation, and enhancing functions appearance are among its established benefits. It is often used medically repair barrier defects, as observed inflammatory conditions like atopic dermatitis (AD) dry types. Furthermore, ceramide metabolites commonly predictors before disease manifestation for prognostication processes, thus can be biomarker clinical diagnosis well. In last couple of decades, momentum was also seen pre‐clinical studies involving anti‐cancer nanotechnology field, whereby drug, carrier, or even adjunct formulation increase efficacy treatment such chemotherapy. Approaches levels include directly replenishing lost ceramides with natural extracts, synthetic pseudo‐ceramides, ceramide‐like analogues, well using supplements that stimulate body's production. Although well‐known skincare common AD psoriasis, development related pharmacology severe conditions, cancer, remain stages. Hence, purpose this research explore role health application diseases.

Language: Английский

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Pathogenesis and management of atopic dermatitis: insights into epidermal barrier dysfunction and immune mechanisms

Published: Feb. 7, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by compromised epidermal barrier and heightened immunoglobulin E (IgE) levels, often associated with filaggrin (FLG) gene mutations. Genetic factors like FLG mutations environmental influences, including microbial exposure pollutants, contribute to the disease’s progression, leading itchy, inflamed skin. AD frequently coexists allergic conditions, severely affecting quality of life. The pathogenesis involves complex interactions between genetic predispositions, immune responses, triggers. Despite advances, development effective treatments remains challenging due an incomplete understanding how influence pathways variability in presentation. Current biomarkers are insufficient fully capture complexity or predict therapeutic highlighting need for novel personalized approaches. Emerging therapies such as chimeric antigen receptor (CAR)-T cell therapy, stem regenerative medicine show promise addressing AD’s root causes. This review explores key aspects pathogenesis, focusing on dysfunction, mechanisms, innovative strategies improve patient outcomes.

Language: Английский

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Dupilumab successfully controlled eczema in Wiskott-Aldrich Syndrome over 52 weeks

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

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