Ultra‐processed foods, allergy outcomes and underlying mechanisms in children: An EAACI task force report

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(9)

Published: Sept. 1, 2024

Abstract Background Consumption of ultra‐processed foods [UPFs] may be associated with negative health outcomes. Limited data exist regarding the potential role UPFs in occurrence allergic diseases. The underlying mechanisms underpinning any such associations are also poorly elucidated. Methods We performed a systematic review and narrative evidence synthesis available literature to assess between UPF consumption pediatric allergy outcomes ( n = 26 papers), including on association seen gut microbiome 16 papers) or immune system 3 structure function following PRISMA guidelines. Results Dietary exposure fructose, carbonated soft drinks, sugar intake was an increased risk asthma, rhinitis, food allergies children. Commercial baby childhood allergy. Childhood fruit juices, sugar‐sweetened beverages, high carbohydrate UPFs, monosodium glutamate, advanced glycated end‐products (AGEs) Exposure common ingredients seem diseases as wheezing, allergies, atopic dermatitis, many, but not all studies. Conclusion More preclinical clinical studies required better define link asthma. These observational ideally require supporting clearly defined consumption, validated dietary measures, mechanistic assessments definitively

Language: Английский

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Role of the microbiome in regulation of the immune system

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Language: Английский

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Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 21, 2024

Recent experimental and epidemiological studies underscore the vital interaction between intestinal microbiota lungs, an interplay known as “gut-lung axis”. The significance of this axis has been further illuminated following identification microbial metabolites, such short-chain fatty acids (SCFA), key mediators in setting tone immune system. Through gut-lung axis, gut its or allergens, are directly indirectly involved immunomodulation pulmonary diseases, thereby increasing susceptibility to allergic airway diseases asthma. Asthma is a complex outcome environmental factors genetic predispositions. concept may offer new targets for prevention treatment This review outlines relationships asthma respiratory microbiome, microbiome. It also discusses current advancements applications microbiomics, offering novel perspectives strategies clinical management chronic like

Language: Английский

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Food allergy in a changing dietary landscape: A focus on the Asia Pacific region

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(8)

Published: Aug. 1, 2024

Recent studies have provided compelling evidence to suggest that various environmental factors play a significant role in the development of food allergies. As our society experiences rapid economic growth, increased urbanization, and shift towards more Westernized diet, incidence allergies is also on rise pattern gradually evolving. This review will delve into changes epidemiology within Asia-Pacific region dietary practices are postulated over years. Although there been important advancements field allergies, still numerous uncertainties regarding intricate relationship between diet Specifically, epigenetic influencing susceptibility as evidenced by assessed impact migration rural-urban dynamics, not fully understood. Addressing this knowledge gap presents an opportunity develop effective prevention treatment strategies could greatly benefit individuals living with

Language: Английский

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Advances in Research on Gut Microbiota and Allergic Diseases in Children

Current Research in Microbial Sciences, Journal Year: 2025, Volume and Issue: 8, P. 100362 - 100362

Published: Jan. 1, 2025

Epidemiological studies indicate a rising prevalence of allergic diseases, now recognized as major global public health concern. In children, the progression these diseases often follows "atopic march," beginning with eczema, followed by food allergies, rhinitis, and asthma. Recent research has linked gut microbiota dysbiosis to development in children. The microbiota, crucial component human health, plays vital role maintaining overall well-being, highlighting its potential preventing modifying course diseases. This review examines relationship between childhood drawing on latest evidence. We first elaborated concepts discussion developmental trajectory healthy further explored richness, diversity, composition well specific microbial taxa associated disease. Lastly, we discussed current status future probiotic interventions managing pediatric

Language: Английский

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Impact of Gut Microbiome Modulating Interventions on Fecal Metabolome of Infants: A Systematic Review and Quality Assessment

PROTEOMICS, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT The development of the gut microbiome in infancy is a vulnerable process that may be perturbed by antibiotics or supported probiotics. Although effects these “biotics” have been well‐studied through DNA sequencing, it remains unclear how resulting compositional changes affect metabolic functions. Additionally, limits method standardization require careful quality assessment studies reporting fecal metabolome. We conducted systematic search Embase and MEDLINE for describing metabolites from term near‐term infants, together with anti‐, pre‐, probiotic intervention. identified 680 articles, which 60 were assessed eligibility 21 included. first developed operational checklists transparent reproducible evaluated metabolomic methodologies. This analysis our aim to summarize metabolome induced biotic interventions. Despite varying methodology, we similarities profiles response specific Among most frequently observed metabolites, consistently reported altered after interventions, bile acids, aromatic amino short‐chain fatty acids. conclude discussion on appropriate experimental design, controls, metabolomics guide future research permitting meta‐analyses.

Language: Английский

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Harnessing the Farm Effect: Microbial Products for the Treatment and Prevention of Asthma Throughout Life

Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)

Published: March 1, 2025

It has long been appreciated that farm exposure early in life protects individuals from allergic asthma. Understanding what component(s) of this is responsible for protection crucial to understanding asthma pathogenesis and developing strategies prevent or treat In review, we introduce the concept Farm-Friends, specific microbes associated with both a environment We review mechanism(s) by which these Farm-Friends suppress inflammation, focus on molecule(s) produced Farm-Friends. Finally, discuss relevance Farm-Friend administration (oral vs. inhaled) preventing development severity throughout childhood adulthood. By fuller modulate host immunity, greater wealth prophylactic therapeutic options becomes available counter current allergy epidemic.

Language: Английский

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Emerging concepts in introducing foods for food allergy prevention

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

This review focuses on the latest information regarding role of complementary feeding practices and food allergen introduction in prevention allergies. Early allergens for allergy is recommended by guidelines supported randomized controlled trials. Diet diversity recommended, studies from Asia. A European study indicated that diet after first year life may still be important prevention. The systematic reviews indicate there an association between ultra-processed intake development. Plant based foods fiber play modulating gut microbiome which has been associated with reduced outcomes. However, increased within a diverse raises questions about excessive calorie protein but can managed focusing infant satiety cues. clearly further supports allergies should not delayed once commenced. to support

Language: Английский

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Effect of Fibers on Microbiome, Health and Allergy

Published: Jan. 1, 2025

Language: Английский

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Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling

iMeta, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract Food allergy (FA) has received increased attention in recent years. Multiple studies have highlighted the crucial role of short‐chain fatty acids (SCFAs) development IgE‐mediated FA. Here, a case‐control approach was employed to analyze SCFAs profiles children with FA, while an ovalbumin (OVA)‐sensitized mouse model utilized explore underlying mechanism by which mitigate Children food‐sensitized tolerance (FST) ( n = 20) or FA 20), and healthy controls (HC) were recruited profiles. The HC group exhibited higher levels fecal samples than FST, FST + groups. Data from OVA‐sensitized showed that butyrate more significant effect on reducing allergic reactions compared other SCFAs. Compared negative control group, OVA‐induced oxidative stress (OS) triggered excessive Notch signaling activation, subsequently impaired both tight junctions integrity mucosal barrier function murine intestinal epithelial cells (IECs). Gut dysbiosis induced mucus layer erosion, thereby elevating IECs exposure food antigens OS, potentiated activation. However, counteracted this loop restoring microbiota structure suppressing reactive oxygen species (ROS)/Notch cascades. Strikingly, low‐dose (0.25–1 mM) protected rat small intestine crypt (IEC‐6) inhibiting ROS, whereas high‐dose (2–5 exacerbated injury activation signaling. Our study revealed potential molecular mechanisms through alleviates allergy, providing therapeutic strategy for its management.

Language: Английский

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