Nanomaterials‐Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Pyroptosis, a form of programmed cell death characterized by lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel intelligent therapeutic strategies cancer, infectious diseases, chronic inflammatory conditions targeted activation reduced systemic toxicity. This review explores the mechanisms which NMs regulate comparing molecular NM inducers, examines role intrinsic properties such as size, shape, surface charge, chemical composition in these processes. It also discusses balance between beneficial adverse effects NM‐induced highlighting delivery systems, modifications, controlled to enhance efficacy intelligence while minimizing Notably, mRNA‐based nanomedicine be intelligently designed activate achieving desired outcomes tailored evolving microenvironment diseases. By understanding interactions, potential harnessed develop innovative treatments manage pyroptosis‐associated diseases safely, effectively, intelligently. highlights transformative clinical applications.

Language: Английский

The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский