IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease DOI

Nicolas Charles,

Ulrich Blank

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: March 31, 2025

Type 2-mediated immune responses protect the body against environmental threats at barrier surfaces, such as large parasites and toxins, facilitate repair of inflammatory tissue damage. However, maladaptive to typically nonpathogenic substances, commonly known allergens, can lead development allergic diseases. 2 immunity involves a series prototype TH2 cytokines (IL-4, IL-5, IL-13) alarmins (IL-33, TSLP) that promote generation adaptive CD4+ helper cells humoral products allergen-specific IgE. Mast basophils are integral players in this network, serving primary effectors IgE-mediated responses. These bind IgE via high-affinity receptors (FcεRI) expressed on their surface and, upon activation by release variety mediators regulate responses, attract modulate other cells, contribute repair. Here, we review biology effector mechanisms these focusing primarily role mediating both physiological pathological contexts.

Language: Английский

Six Injections of Modified Adjuvanted PQ Grass Is Effective and Well‐Tolerated in a Pivotal Phase III Trial DOI Creative Commons
Stefan Zielen, Jonathan A. Bernstein, Gunter J. Sturm

et al.

Allergy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

ABSTRACT Background PQ Grass 27600 SU (PQ Grass) cumulative dose is a pre‐seasonal, six‐injection, aluminium‐free, modified subcutaneous immunotherapy product under development for the treatment of allergic rhinitis (AR). A pivotal Phase III randomised double‐blind, placebo‐controlled clinical trial was performed to evaluate efficacy and safety in subjects with seasonal AR. Methods An adaptive group sequential PQGrass306 (G306) one pre‐defined interim analysis designed, using 2 parallel groups applying 1:1 active versus placebo randomisation patients aged 18–65. The primary endpoint EAACI (European Academy Allergy Clinical Immunology) Combined Symptom Medication Score (EAACI‐CSMS 0–6 ) averaged over peak grass pollen season (GPS). Results 858 were screened 555 randomised. Based on results analysis, stopped success showing superiority favour Grass. EAACI‐CSMS (peak GPS) demonstrated highly significant clinically meaningful point difference −0.27 points (95% CI: −0.42 −0.12), corresponding relative −20.3% ( p = 0.0005). Highly consistent beneficial obtained all key secondary endpoints. Significant induction blocking IgG4 IgA antibody subclasses occurred. well tolerated, no unexpected signals Conclusions This effect as supportive profile.

Language: Английский

Citations

2
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease DOI

Nicolas Charles,

Ulrich Blank

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: March 31, 2025

Type 2-mediated immune responses protect the body against environmental threats at barrier surfaces, such as large parasites and toxins, facilitate repair of inflammatory tissue damage. However, maladaptive to typically nonpathogenic substances, commonly known allergens, can lead development allergic diseases. 2 immunity involves a series prototype TH2 cytokines (IL-4, IL-5, IL-13) alarmins (IL-33, TSLP) that promote generation adaptive CD4+ helper cells humoral products allergen-specific IgE. Mast basophils are integral players in this network, serving primary effectors IgE-mediated responses. These bind IgE via high-affinity receptors (FcεRI) expressed on their surface and, upon activation by release variety mediators regulate responses, attract modulate other cells, contribute repair. Here, we review biology effector mechanisms these focusing primarily role mediating both physiological pathological contexts.

Language: Английский

Citations

0