Editorial: T and B cell immune dynamics in allergic response DOI Creative Commons
Mrinmoy Das, Tarun Keswani

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 6

Published: Feb. 12, 2025

IL-10 and TGF-β, but their role is not fully understood (3). Further research on Tr1 cells could lead to new allergy treatments. A large body of evidence shows that B are key players in allergic responses, primarily through the production IgE antibodies trigger reactions. In addition pivotal pathogenesis allergies, also involved regulation immune response antigen presentation, Researchers led by Pablo-Torres et al., (5) uncovered a link between severe metabolic problems, impaired function. Their study revealed asthma patients have distinct T-cell gene expression profiles, marked pathways disruptions, reduced energy production, increased inflammation. Specifically, genes (oxidative phosphorylation, fatty acid oxidation, glycolysis) were downregulated, while coding for inflammatory cytokines (IL-19, IL-23A, IL-31) upregulated.Additionally, TGF-β pathway, as well Tregs percentage downregulated indicating regulatory function these cohorts asthmatic patients. Notably, cases food allergy, deletion TGF-β1 differentiation RORγt+ Treg cells, leading mast cell expansion gut susceptibility development (6). These findings shed light complex relationships regulation, metabolism, inflammation, paving way novel therapeutic approaches.

Language: Английский

Editorial: T and B cell immune dynamics in allergic response DOI Creative Commons
Mrinmoy Das, Tarun Keswani

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 6

Published: Feb. 12, 2025

IL-10 and TGF-β, but their role is not fully understood (3). Further research on Tr1 cells could lead to new allergy treatments. A large body of evidence shows that B are key players in allergic responses, primarily through the production IgE antibodies trigger reactions. In addition pivotal pathogenesis allergies, also involved regulation immune response antigen presentation, Researchers led by Pablo-Torres et al., (5) uncovered a link between severe metabolic problems, impaired function. Their study revealed asthma patients have distinct T-cell gene expression profiles, marked pathways disruptions, reduced energy production, increased inflammation. Specifically, genes (oxidative phosphorylation, fatty acid oxidation, glycolysis) were downregulated, while coding for inflammatory cytokines (IL-19, IL-23A, IL-31) upregulated.Additionally, TGF-β pathway, as well Tregs percentage downregulated indicating regulatory function these cohorts asthmatic patients. Notably, cases food allergy, deletion TGF-β1 differentiation RORγt+ Treg cells, leading mast cell expansion gut susceptibility development (6). These findings shed light complex relationships regulation, metabolism, inflammation, paving way novel therapeutic approaches.

Language: Английский

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