Fathers in focus: Periconceptional paternal exposures and their lasting impact on offspring health DOI Open Access
Michael L. Eisenberg, Sandra Søgaard Tøttenborg

Andrology, Journal Year: 2024, Volume and Issue: 13(1), P. 5 - 6

Published: Dec. 12, 2024

We are pleased to introduce this special issue of Andrology, dedicated exploring the impact paternal exposures on pregnancy outcomes and offspring health. This collection highlights an often-overlooked aspect reproductive health: how fathers' contributions shape not only but also long-term well-being their children. With expanding body experimental evidence, we have evolved beyond notion that sperm competition alone removes compromised sperm. Indeed, preclinical data demonstrate prenatal increase risks abnormal embryo development, implantation failure, loss. However, progress in human studies has been slower, partly due a lack robust parent-child (including father) infertility cohorts, as well limitations high-throughput techniques assess genetic epigenetic influences. these tools more readily available, research is advancing our understanding factors such diet, environmental toxins, stress, age can health–affecting everything from birth disease risks–independent maternal Just deeper insights into health improved child outcomes, increasing knowledge holds similar potential. As Anakwe et al.1 issue, potential rather large considering high rates poor preconception including marijuana use, obesity, sexually transmitted among men age. The papers cover four themes: 1) health/behavioral 2) male-mediated mechanisms, 3) associated with recurrent loss (RPL), 4) assisted technology (ART) outcomes. Regarding Leader al.2 found urinary concentrations parabens linked adverse behavior mixture effects showing stronger associations than individual substances. Atieh al.3 reported recreational physical activity be reduced risk congenital heart offspring, whereas sedentary smoking were increased risk. Achkar al.4 higher mass index (BMI) before conception was urogenital anomalies Aubert al.5 fathers unfavorable lifestyle contribute greater waist-to-height ratio children, although directly childhood obesity. A review by Venigalla al.6 suggested male obesity negatively impacts quality, ART increases gestational abnormalities weight variability, though may reverse some effects. In contrast, Lund al.7 no association between exposure non-steroidal anti-inflammatory drugs or opioids Similarly, Hærvig al.8 semen quality adult sons after adjusting for self-reported biologically verified cotinine levels. Finally, Ernst al.9 parental at biomarkers fecundity young Danish men. Considering Dehghanbanadaki al.10 reviewed biological mechanisms which de novo mutations transgenerational effects, emphasizing importance changes. Yang al.11 alterations small non-coding RNA mice autoimmune epididymo-orchitis led metabolic dysfunction offspring. RPL highlight significant role influencing Inversetti al.12 conducted systematic meta-analysis revealing DNA fragmentation specific parameters significantly RPL, while BMI, smoking, alcohol intake showed correlation. Another emphasized like age, syndrome, chromosomal abnormalities, RPL.13 Lindman al.14 cases indicating choices partners adversely affect Lastly, Romano al.15 examined obstetric testicular extraction followed intracytoplasmic injection cycles, despite spermatogenic non-obstructive azoospermia, different those obstructive azoospermia cases. current evidence demonstrating paternally mediated need further benchtop attention prospective clinic.

Language: Английский

Hypogonadism in Fathers and Perinatal Outcomes in Offspring: A Retrospective Analysis of U.S. Claims Data DOI

E Hernandez-Vegas,

Odinachi Moghalu,

Joshua J. Horns

et al.

Urology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
TLR signaling pathway and the effects of main immune cells and epigenetics factors on the diagnosis and treatment of infertility and sterility DOI Creative Commons

Kosar Babaei,

Mohsen Azimi Nezhad,

Seyedeh Nafise Sedigh Ziabari

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35345 - e35345

Published: July 27, 2024

Recurrent pregnancy loss (RPL), often known as spontaneous miscarriages occurring two or more times in a row, is reproductive disease that affects certain couples. The cause of RPL unknown many cases, leading to difficulties therapy and increased psychological suffering Toll-like receptors (TLR) have been identified crucial regulators inflammation various human tissues. occurrence during parturition indicates receptor activity tissues related may play role the onset continuation normal function, well complications like infection-related preterm. TLRs their signaling molecules serve effective therapeutic targets for inhibiting premature activity. At maternal-fetal interface, are found both immune non-immune cells, such trophoblasts decidual cells. TLR expression patterns influenced by phases pregnancy. In this way, translational combinations epigenetics, indicated impact on TLRs.Importantly, abnormal DNA methylation histone alterations an impressive performance decreasing fertility influencing gene required molecular cellular activities which vital embryonic process. TLRs, central duty innate system can regulate epigenetic elements different pathways. potential roles epigenetics factors ability identify react infections, place will all be covered narrative review essay.

Language: Английский

Citations

2
Paternal age, de novo mutations, and offspring health? New directions for an ageing problem DOI Creative Commons
R. John Aitken

Human Reproduction, Journal Year: 2024, Volume and Issue: 39(12), P. 2645 - 2654

Published: Oct. 3, 2024

This Directions article examines the mechanisms by which a father's age impacts health and wellbeing of his children. Such are significant include adverse birth outcomes, dominant genetic conditions, neuropsychiatric disorders, variety congenital developmental defects. As well as age, wide environmental lifestyle factors also known to impact offspring via changes mediated male germ line. picture dynamic line responsive range intrinsic extrinsic contrasts with results trio studies indicating that incidence mutations in is low exhibits linear, monotonic increase paternal (∼two new per year). While traditional explanation for this pattern mutation has been metronomic plod replication errors, an alternative model pivots around 'faulty male' hypothesis. According concept, integrity can be dynamically impacted other factors, it aberrant repair such damage drives mutagenesis. Fortunately, DNA proofreading during spermatogenesis extremely effective these mutant cells either repaired or deleted apoptosis/ferroptosis. There appear only two escape apoptotic fate: (i) if acquire enhancing proliferation suppressing apoptosis, permits their clonal expansion (selfish selection hypothesis) (ii) genetically damaged spermatozoon manages fertilize oocyte, then fixes (or epimutation) result defective (oocyte collusion hypothesis). Exploration proposed should not help us better understand aetiology effects but inform potential avenues remediation.

Language: Английский

Citations

0
Fathers in focus: Periconceptional paternal exposures and their lasting impact on offspring health DOI Open Access
Michael L. Eisenberg, Sandra Søgaard Tøttenborg

Andrology, Journal Year: 2024, Volume and Issue: 13(1), P. 5 - 6

Published: Dec. 12, 2024

We are pleased to introduce this special issue of Andrology, dedicated exploring the impact paternal exposures on pregnancy outcomes and offspring health. This collection highlights an often-overlooked aspect reproductive health: how fathers' contributions shape not only but also long-term well-being their children. With expanding body experimental evidence, we have evolved beyond notion that sperm competition alone removes compromised sperm. Indeed, preclinical data demonstrate prenatal increase risks abnormal embryo development, implantation failure, loss. However, progress in human studies has been slower, partly due a lack robust parent-child (including father) infertility cohorts, as well limitations high-throughput techniques assess genetic epigenetic influences. these tools more readily available, research is advancing our understanding factors such diet, environmental toxins, stress, age can health–affecting everything from birth disease risks–independent maternal Just deeper insights into health improved child outcomes, increasing knowledge holds similar potential. As Anakwe et al.1 issue, potential rather large considering high rates poor preconception including marijuana use, obesity, sexually transmitted among men age. The papers cover four themes: 1) health/behavioral 2) male-mediated mechanisms, 3) associated with recurrent loss (RPL), 4) assisted technology (ART) outcomes. Regarding Leader al.2 found urinary concentrations parabens linked adverse behavior mixture effects showing stronger associations than individual substances. Atieh al.3 reported recreational physical activity be reduced risk congenital heart offspring, whereas sedentary smoking were increased risk. Achkar al.4 higher mass index (BMI) before conception was urogenital anomalies Aubert al.5 fathers unfavorable lifestyle contribute greater waist-to-height ratio children, although directly childhood obesity. A review by Venigalla al.6 suggested male obesity negatively impacts quality, ART increases gestational abnormalities weight variability, though may reverse some effects. In contrast, Lund al.7 no association between exposure non-steroidal anti-inflammatory drugs or opioids Similarly, Hærvig al.8 semen quality adult sons after adjusting for self-reported biologically verified cotinine levels. Finally, Ernst al.9 parental at biomarkers fecundity young Danish men. Considering Dehghanbanadaki al.10 reviewed biological mechanisms which de novo mutations transgenerational effects, emphasizing importance changes. Yang al.11 alterations small non-coding RNA mice autoimmune epididymo-orchitis led metabolic dysfunction offspring. RPL highlight significant role influencing Inversetti al.12 conducted systematic meta-analysis revealing DNA fragmentation specific parameters significantly RPL, while BMI, smoking, alcohol intake showed correlation. Another emphasized like age, syndrome, chromosomal abnormalities, RPL.13 Lindman al.14 cases indicating choices partners adversely affect Lastly, Romano al.15 examined obstetric testicular extraction followed intracytoplasmic injection cycles, despite spermatogenic non-obstructive azoospermia, different those obstructive azoospermia cases. current evidence demonstrating paternally mediated need further benchtop attention prospective clinic.

Language: Английский

Citations

0