Clinical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

ABSTRACT Oligoasthenoteratozoospermia (OAT) is a frequent but severe type of male infertility. As one the most multifaceted infertility resulting from sperm problems, its genetic etiology remains unknown in cases. In this review, we systematically sort out latest literature on clinical reports and animal models leading to OAT, summarise expression profiles causative genes for highlight important role protein transport system during spermiogenesis, spermatid cell‐specific genes, Golgi acrosome‐related manchette‐related HTCA‐related axoneme‐related OAT development. These would be instrumental etiological screening, counseling, pre‐implantation testing patients with OAT.

Language: Английский