Is There a Link between the 2021 COVID-19 Vaccination Uptake in Europe and 2022 Excess All-Cause Mortality?

Asian Pacific Journal of Health Sciences, Journal Year: 2023, Volume and Issue: 10(1), P. 25 - 31

Published: March 13, 2023

Purpose: We primarily study a possible link between 2021 COVID-19 vaccination uptake in Europe and monthly 2022 excess all-cause mortality, that is, mortality higher than before the pandemic. Methods Results: Analyses of 31 countries weighted by population size show during first 9 months increased more uptake; one percentage point increase was associated with 0.105% (95% CI, 0.075–0.134). When controlling for alternative explanations, association remained robust, we discuss result emphasizing causality as well potential ecological fallacy. Furthermore, shows lower uptake, but this became non-significant when explanations. Conclusion: Despite preventive effect 2021, cannot rule out has led to increasing January September.

Language: Английский

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Is there a Link between the 2021 COVID-19 Vaccination Uptake in Europe and 2022 Excess All-Cause Mortality?

Published: Feb. 21, 2023

We primarily study a possible link between 2021 COVID-19 vaccination uptake in Europe and monthly 2022 excess all-cause mortality, i.e., mortality higher than before the pandemic. Analyses of 31 countries weighted by population size show that during first nine months increased more uptake; one percentage point increase was associated with 0.105 percent (95% CI, 0.075-0.134). When controlling for alternative explanations, association remained robust, we discuss result emphasizing causality as well potential ecological fallacy. Also, shows lower uptake, but this became non-significant when explanations.

Language: Английский

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Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 20, 2024

Abstract Due to the synchronous circulation of seasonal influenza viruses and severe acute respiratory coronavirus 2 (SARS-CoV-2) which causes disease 2019 (COVID-19), there is need for routine vaccination both COVID-19 reduce severity. Here, we prepared individual WPVs composed formalin-inactivated SARS-CoV-2 WK 521 (Ancestral strain; Co WPV) or virus [A/California/07/2009 (X-179A) (H1N1) pdm; Flu WPV] produce a two-in-one Co/Flu WPV. Serum analysis from vaccinated mice revealed that single dose WPV induced antigen-specific neutralizing antibodies against viruses, similar those by either type alone. Following infection with virus, showed no weight loss, reduced pneumonia viral titers in lung, lower gene expression proinflammatory cytokines, as observed WPV-vaccinated. Furthermore, pentavalent vaccine (Co/qFlu comprising quadrivalent (qFlu was immunogenic protected animals COVID-19. These results suggest provides efficient protection infections evidence interference mice. We propose concomitant can be useful controlling diseases.

Language: Английский

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Evaluation of Immunogenicity and Safety of Vero Cell-Derived Inactivated COVID-19 Vaccine in Older Patients with Hypertension and Diabetes Mellitus

Vaccines, Journal Year: 2022, Volume and Issue: 10(7), P. 1020 - 1020

Published: June 25, 2022

To evaluate the immunogenicity and safety of COVID-19 vaccine (Vero cell), inactivated, in a population aged ≥60 years with hypertension or(/and) diabetes mellitus.A total 1440 participants were enrolled divided into four groups, 330 group, 300 hypertensive combined group (combined disease group), 480 healthy group. Two doses administered at 21-day interval blood samples collected before vaccination 28 days after second dose to immunogenicity. The adverse events changes pressure glucose levels recorded.The seroconversion rate neutralizing antibodies was 100% for all participants. post-inoculation geometric mean titer (GMT) groups hypertension, diabetes, disease, populations 73.41, 69.93, 73.84, 74.86, respectively. rates post-vaccination GMT non-inferior vaccine-related reactions 11.93%, 14.29%, 12.50%, 9.38%, No serious reported during study. apparent abnormal fluctuations values observed diabetes.The showed good patients suffering from mellitus.

Language: Английский

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More antibodies are not always better: Fc effector functions play a critical role in SARS-CoV-2 infection and protection

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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