Accelerometer-based sedentary time and physical activity from childhood through young adulthood with progressive cardiac changes: a 13-year longitudinal study

European Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: 31(12), P. 1480 - 1492

Published: May 7, 2024

Abstract Aims Longitudinal evidence on the relationship of sedentary time (ST), light-intensity physical activity (LPA), and moderate-to-vigorous-intensity (MVPA) with changes in cardiac structure function paediatric population is scarce. This clinically important due to impact ST can have long-term prognosis healthy young lifetime continuum. prospective observational study examined relationships cumulative ST, LPA, MVPA from childhood longitudinal function. Methods results a secondary analysis Avon Study Parents Children, UK birth cohort 1682 children aged 11 years. Participants who had at least one follow-up timepoints accelerometer-measured over period 13 years repeated echocardiography-measured ages 17- 24-year clinic visit were included. Left ventricular mass indexed for height2.7 (LVMI2.7) left (LV) diastolic mitral E/A ratio (LVDF) computed. Among (mean [SD] age, 11.75 [0.24] years; 1054 [62.7%] females), one-min/day increase 24 was associated progressively increased LVMI2.7 {effect estimate 0.002 g/m2.7 [confidence interval (CI) 0.001–0.003], P < 0.001}, irrespective sex, obesity, hypertensive status. Cumulative LPA decreased (−0.005 [−0.006 −0.003], 0.0001) but an LVDF. one-minute/day (0.003 [0.001–0.006], = 0.015). Conclusion contributed +40% 7-year mass, by +5%, reduced −49%. Increased may pathologic effects during growth through adulthood; however, engaging enhance health population.

Language: Английский

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Accelerometer-based sedentary time and physical activity with MASLD and liver cirrhosis in 2684 British adolescents

npj gut and liver., Journal Year: 2024, Volume and Issue: 1(1)

Published: May 29, 2024

Abstract Evidence on the long-term relationship of sedentary time (ST), light physical activity (LPA) and moderate-to-vigorous PA (MVPA) with liver steatosis, fibrosis, cirrhosis, changes in enzymes paediatric population is limited. This study examined associations cumulative ST, LPA MVPA from childhood longitudinal indices enzymes. From Avon Longitudinal Study Parents Children (ALSPAC), UK birth cohort, 2684 children aged 11 years who had at least one follow-up time-points accelerometer-measured over a period 13 years, measures age 24 clinic visit were included. Liver steatosis fibrosis assessed by transient elastography staged as stage F0-F4 grade (S0-S3) years. Alanine aminotransferase (ALT), aspartate (AST), γ-glutamyl transferase (GGT) assayed ages 17 using generalized linear mixed-effect models, while mediation analyses conducted structural equation models. Among (mean [SD] age, 11.75 [0.24] years; 1537 [57.3%] females]), prevalence was 2.6% 20.5% The 1-minute/day increase ST 11–24 associated higher odds cirrhosis (odds ratio 1.004 [95% CI 1.002–1.005] p < 0.001) severe (1.001 [1.001–1.002] = 0.002) Increased directly progressively increased ALT, AST GGT to Cumulative 1-min/day lower (0.990 [0.990–0.991] (0.999 [0.998–0.999] well decreased (0.996 [0.994–0.998] but not effect lowering significantly suppressed (64% suppression) fat mass. In conclusion, increasing LPA, sustaining decreasing may independently attenuate reverse risk young adulthood.

Language: Английский

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Lean Mass Longitudinally Confounds Sedentary Time and Physical Activity With Blood Pressure Progression in 2513 Children

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

ABSTRACT Background Randomized controlled trials have reported no effect of moderate‐to‐vigorous physical activity (MVPA) on reducing blood pressure (BP) in youth, probably due to short trial durations. This study examined the longitudinal sedentary time (ST), light PA (LPA) and MVPA BP 11‐year‐old children followed up for 13 years determine confounding mediating role body composition. Methods Data included 2513 from Avon Longitudinal Study Parents Children (ALSPAC), UK birth cohort who had data at least one time‐point measure accelerometer‐based movement behaviour across follow‐up complete measures ages 11, 15 24 years. Body composition was assessed with dual‐energy x‐ray absorptiometry all points. Multivariate adjusted generalized linear mixed‐effect model structural equation causal mediation analyses were conducted. Results Among participants (61% female, mean [SD] age 11.72 [0.21] years), ST steadily increased ~6 h/day childhood (age 11 years) ~9 young adulthood whereas LPA decreased, but an inverted U‐shaped increase. In analysis, after full adjustment, a 1‐min cumulative positively associated systolic (0.009 mmHg [95% CI 0.007–0.011]; p < 0.001) diastolic BP. A inversely (−0.007 [−0.009 −0.004]; 0.001), not isotemporal substitution analyses, replacement 10 min equal during childhood, adolescence cumulatively decreased by −2.63 −3.17 −2.08] ( 0.0001) −1.93 −2.36 −1.50] 0.0001). Replacing statistically significant absolute lean mass. The association fully mediated mass (93% mediation). Increased total fat partially (19%–27%) inverse associations Conclusions Theoretically replacing min/day spent growth through may lower −3 −2 mmHg. Lean seems more than relations should be accounted future intervention studies paediatric adult population.

Language: Английский

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Physical Activity and Arterial Stiffness: A Narrative Review

Journal of Clinical Hypertension, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 17, 2024

Arterial stiffness is a significant predictor of cardiovascular disease and mortality. Physical activity (PA) has been extensively studied for its potential to reduce arterial stiffness, but the relationship between different types, durations, intensities PA remains topic ongoing research. Therefore, in this narrative review, we evaluated current evidence focusing on effect vascular health discussed known underlying physiological mechanisms. PA, irrespective intensity or pattern, consistently associated with lower stiffness. Aerobic exercise, particularly at higher intensities, most effective strategy reducing These benefits are especially populations risk, such as those type 2 diabetes mellitus hypertension. maintaining an active lifestyle into older age crucial may contribute healthy aging.

Language: Английский

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JHH Young Investigator Award 2023: interview with the winner Andrew O. Agbaje

Journal of Human Hypertension, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Language: Английский

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Sensitization of the Reinforcing Value of Food is Associated with Greater BMI Percentile in Lower Income Adolescents

Published: Jan. 1, 2024

Language: Английский

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Accelerometer-based Sedentary Time and Physical Activity with Incident and Progressive Tobacco Smoking in 2503 Children: A 13-Year Mediation and Temporal Longitudinal Study

Behaviour Research and Therapy, Journal Year: 2024, Volume and Issue: 185, P. 104674 - 104674

Published: Dec. 18, 2024

Long-term accelerometer-based studies examining whether engaging in physical activity (PA) reduces the risk of smoking children are lacking, and directly measured adiposity increases is uncertain.

Language: Английский

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