Host‐microbiome homeostasis: Unveiling the complex interactions shaping health and disease

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(4)

Published: March 23, 2025

The relationship between the human body and its microbial communities is becoming increasingly recognized as essential to our overall health. What we once thought of a mere collection bacteria, fungi, other microorganisms now turns out play far more active role in maintaining health or contributing disease. This connection, known host-microbiome homeostasis, refers balance bodies microbes residing within us. When this disrupted, it can lead conditions such obesity, asthma, epilepsy, even heart Recent studies field shed light on nature coexistence pave way toward therapies that harness power microbiome treat variety issues. special series builds Acta Physiologica's strong standing field1-3 comprises delving into different aspects research. From using engineered bacteria fight metabolic diseases exploring diet early-life exposure these highlight just how interconnected with living One studies, led by Ciocan Elinav,4 explores idea genetically change gut ways disorders like obesity diabetes. It fascinating step developing new treatments could shift for better A further article highlights gut-lung axis microbiota might influence asthma. Early-life exposures may major determining whether child likely develop Factors babies are born, they breastfed, their early diets all development microbiome, which turn affects immune responses. mean targeting on, there be opportunities prevent asthma before begins. Pirr colleagues explore neonate respiratory microbiome.5 For long time, assumed tract was relatively sterile; yet, gut, home microbes. study reveals develops newborns factors delivery method, diet, infections shape lungs. Understanding interact system children. Diet another area where shows influence, outlined Schoeler his team.6 We know drastic changes dramatically alter microbiome. subtle effects typical, everyday dietary variations. By observing small shifts both humans mice, research suggests moderate noticeable composition, potentially offering personalized approach diet-based interventions. Moving realm neurology, Diaz-Marugan focus epilepsy.7 Some patients drug-resistant epilepsy struggle find treatment options. appears from those whose responds treatment. Interestingly, ketogenic have been used work influencing Metformin, drug commonly diabetes, has also shown surprising beyond blood sugar regulation. Wimmer's metformin microbiome,8 increasing production short-chain fatty acids, anti-inflammatory effects. These were linked improvements pressure function rats, absence finding additional cardiovascular benefits an exciting investigation. illustrates deeply intertwined many everything metabolism brain health, systems. As learn about becomes clearer restoring healthy key treating wide range diseases.9, 10 With findings, future medicine understanding working rather than against them. None.

Language: Английский

Targeting gut-immune-heart modulate cardiac remodeling after acute myocardial infarction

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123606 - 123606

Published: April 1, 2025

The gut microbiota interacts with the host to regulate disease and health status. An increasing number of studies have recognized bidirectional regulation between immune cells, which plays a significant role in etiology prognosis diseases. Gut is also crucial regulatory factor cardiovascular After acute myocardial infarction, endothelial damage rapidly triggers an inflammatory response, activating system disrupting ecology, thereby affecting cardiac remodeling after infarction potentially leading heart failure. We elucidated mechanisms complex intercellular networks during infarction. Furthermore, this research examines roles microbiota, metabolites relation failure Finally, we discuss potential targeting cells as effective approach prevent treat future, through methods such dietary regulation, probiotic supplementation, transplantation.

Language: Английский