Hepatology Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 29, 2024
Abstract
Aim
Gamma‐glutamyltransferase
(GGT)
is
known
as
an
oxidative
stress
marker,
induced
by
alcohol
consumption
and
metabolic
disorders,
reported
a
predictor
of
hepatocellular
carcinoma
(HCC)
development
after
hepatitis
C
virus
(HCV)
elimination.
However,
it
not
clear
whether
GGT
serves
simply
surrogate
marker
for
overlapping
diseases
or
reflects
HCV‐specific
carcinogenicity.
We
investigated
the
association
between
hepatocarcinogenesis
achieving
sustained
viral
response
(SVR),
accounting
drinking
habits
diabetes,
examined
predisposing
factors
associated
with
levels
SVR.
Methods
This
prospective,
multicenter,
observational
study
using
database
1001
patients
HCV
eradication
direct‐acting
antiviral
agents.
The
at
SVR
cumulative
HCC
was
in
multivariate
analysis
Cox
proportional
hazard
models
adjustment
covariates
including
diabetes.
markers
genetic
analyzed.
Results
High
were
(HR]
2.38,
95%
CI
1.10–5.17).
also
significant
when
restricted
to
without
diabetes
(HR
8.38,
2.87–24.47).
correlated
serum
growth
differentiation
factor
15
levels,
mitochondrial
dysfunction.
Single‐nucleotide
polymorphisms
ZNF827
GDF15
high
levels.
Conclusions
are
influenced
predisposition
may
reflect
dysfunction
eradication.
Therapeutic Advances in Endocrinology and Metabolism,
Journal Year:
2022,
Volume and Issue:
13
Published: Jan. 1, 2022
Metabolic
dysfunction–associated
fatty
liver
disease
(MAFLD)
has
appeared
as
the
leading
worldwide.
Whereas
terminology
nonalcoholic
(NAFLD)
mainly
reflected
a
negative
selection
and
exclusion
of
alcohol-related
(ALD),
new
definition
made
its
focus
on
association
MAFLD
with
overweight/obesity,
type
2
diabetes
metabolic
risk
factors
especially
also
in
normal
weight/lean
subjects.
Several
studies
from
past
years
have
now
used
provided
substantial
information
that
this
might
be
accurate.
Studies
evidence
advantageous
characterization
identification
patients
significant
fibrosis.
This
been
demonstrated
well-known
Rotterdam
study
which
MAFLD-only
group
showed
higher
rate
fibrosis
stiffness.
able
to
predict
all-cause
mortality
Third
National
Health
Nutrition
Examination
Survey.
Furthermore,
improve
cardiovascular
patient
population.
As
term
not
yet
accepted
universally,
it
remains
important
coordinate
efforts
globally
adapt
involve
all
specialities
dealing
disorders
such
diabetologists
further
prepare
medical
community
for
future
use.
The
aim
review
is
summarize
critically
address
emerging
over
usage
could
helpful
daily
clinical
practice.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114913 - 114913
Published: May 19, 2023
Hepatic
steatosis
is
a
common
condition
found
in
the
liver
of
hepatitis
C
virus
(HCV)-infected
patients,
contributing
to
more
severe
forms
disease.
In
addition,
human
immunodeficiency
(HIV)
may
accelerate
this
process.
Alternatively,
several
immune
checkpoint
proteins
have
been
reported
be
upregulated
and
correlated
with
disease
progression
during
HCV
HIV
infections.
steatosis,
detrimental
system
activation
has
established;
however,
role
checkpoints
not
addressed
so
far.
Thus,
study
aimed
evaluate
association
between
plasma
at
baseline
(before
antiviral
therapy)
hepatic
index
(HSI)
increase
end
follow-up
(∼
five
years
after
sustained
virologic
response
(SVR)).
We
performed
multicenter
retrospective
62
patients
coinfected
HIV/HCV
who
started
therapy.
Immune
were
analyzed
using
Luminex
200TM
analyzer.
The
statistical
analysis
was
carried
out
Generalized
Linear
Models
(GLM)
Partial
Least
Squares
Discriminant
Analysis
(PLS-DA).
Fifty-three
percent
showed
HSI
from
follow-up.
Higher
protein
levels
BTLA,
CD137(4-1BB),
CD80,
GITR,
LAG-3,
PD-L1
before
therapy
associated
long-term
successful
therapy,
suggesting
potential
predictive
for
early
detection
towards
HIV/HCV-coinfected
patients.
Journal of Gastroenterology and Hepatology,
Journal Year:
2023,
Volume and Issue:
39(1), P. 193 - 201
Published: Sept. 20, 2023
Abstract
Background
and
Aim
The
prevalence
of
metabolic
dysfunction‐associated
fatty
liver
disease
(MAFLD)
its
interplay
with
hepatitis
B
virus
(HBV)
C
(HCV)
in
terms
severity
is
elusive.
Methods
A
mass
surveillance
program
was
conducted
a
viral
endemic
area.
objective
to
identify
MAFLD/non‐MAFLD
subjects
advanced
disease.
Results
Two
thousand
two
hundred
forty‐two
(41.7%)
the
5378
were
identified
as
having
MAFLD,
375
(7.0%)
had
proportions
anti‐HCV
HBsAg
seropositivity
19.3%
9.7%,
respectively.
fibrosis
non‐viral
(NBNC),
HBV
HCV
infection
2.8%,
5.7%
23.4%,
Subjects
MAFLD
significantly
higher
proportion
(8.7%
vs
5.7%,
P
<
0.001).
Factors
associated
included
age
(odds
ratio
[OR]/95%
confidence
interval
[CI]:
4.8/3.7–6.0,
0.001),
male
sex
(OR/CI:
1.3/1.0–1.7,
=
0.019),
5.9/4.6–7.5,
MAFLD‐lean
dysregulation
(MS)
2.6/1.3–5.2,
0.005;
compared
non‐MAFLD
group)
MAFLD‐diabetes
1.5/1.1–2.1,
0.008;
group).
did
not
aggravate
patients
hepatitis.
However,
among
NBNC
subjects,
factors
MS
group
9.1/2.4–34.6,
0.001;
MAFLD‐DM
2.0/1.2–3.2,
0.004;
Conclusions
diabetes
risk
effect
more
significant
community
level.
HepatoBiliary Surgery and Nutrition,
Journal Year:
2024,
Volume and Issue:
13(4), P. 650 - 661
Published: April 22, 2024
Hepatocellular
carcinoma
(HCC)
poses
a
significant
global
health
burden
and
ranks
as
the
fifth
most
prevalent
cancer
on
scale.
Hepatitis
C
virus
(HCV)
infection
remains
one
of
major
risk
factors
for
HCC
development.
is
heterogeneous
disease,
development
caused
by
HCV
intricate
involves
various
factors,
including
genetic
susceptibility,
viral
immune
response
due
to
chronic
inflammation,
alcohol
abuse,
metabolic
dysfunction
associated
with
fatty
liver
disease.
In
this
review,
we
provide
comprehensive
updated
review
research
genetics
epigenetic
mechanisms
implicated
in
developing
infection.
We
also
discuss
potential
translational
implications,
novel
biomarkers
drugs
treatment.
Hepatology Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 29, 2024
Abstract
Aim
Gamma‐glutamyltransferase
(GGT)
is
known
as
an
oxidative
stress
marker,
induced
by
alcohol
consumption
and
metabolic
disorders,
reported
a
predictor
of
hepatocellular
carcinoma
(HCC)
development
after
hepatitis
C
virus
(HCV)
elimination.
However,
it
not
clear
whether
GGT
serves
simply
surrogate
marker
for
overlapping
diseases
or
reflects
HCV‐specific
carcinogenicity.
We
investigated
the
association
between
hepatocarcinogenesis
achieving
sustained
viral
response
(SVR),
accounting
drinking
habits
diabetes,
examined
predisposing
factors
associated
with
levels
SVR.
Methods
This
prospective,
multicenter,
observational
study
using
database
1001
patients
HCV
eradication
direct‐acting
antiviral
agents.
The
at
SVR
cumulative
HCC
was
in
multivariate
analysis
Cox
proportional
hazard
models
adjustment
covariates
including
diabetes.
markers
genetic
analyzed.
Results
High
were
(HR]
2.38,
95%
CI
1.10–5.17).
also
significant
when
restricted
to
without
diabetes
(HR
8.38,
2.87–24.47).
correlated
serum
growth
differentiation
factor
15
levels,
mitochondrial
dysfunction.
Single‐nucleotide
polymorphisms
ZNF827
GDF15
high
levels.
Conclusions
are
influenced
predisposition
may
reflect
dysfunction
eradication.
