Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH—Authors’ reply DOI Open Access
Sandeep Bansal, Meena B. Bansal

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(5), P. 662 - 663

Published: July 30, 2024

LINKED CONTENT This article is linked to Bansal et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18124 .

Language: Английский

Lipogenesis and MASLD: re-thinking the role of SREBPs DOI
Hayato Nakagawa

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis DOI Creative Commons

Senlin Lian,

Meixi Lu,

Luo Jiajing

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Conjugated lithocholic acid (LCA) plays a critical role in the development of metabolic dysfunction‐associated steatotic liver disease (MASLD). In this process, hepatocyte inflammation‐caused upregulation its receptor, Takeda G protein‐coupled receptor 5 (TGR5) is crucial factor. Serum bile profiling shows an increase conjugated LCA, which correlates with severity. Depletion Gpbar1 hepatocytes significantly protects against progression from MASLD to steatohepatitis (MASH) that related LCA. vivo and vitro experiments indicate TGR5 activation promotes lipotoxicity‐induced cell death inflammation by suppressing de novo carnitine biosynthesis. Mechanistically, binding CD36 facilitates E3 ubiquitin ligase TRIM21 recruitment, leading degradation BBOX1, enzyme Targeting therapeutically can restore biosynthesis, may offer potent strategy prevent or reverse transition MASH.

Language: Английский

Citations

0
Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents DOI
Youngha Choi, Hyejin Yang, Soyoung Jeon

et al.

European Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 78(10), P. 864 - 871

Published: July 26, 2024

Language: Английский

Citations

2
Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH DOI Open Access
Jannis Kountouras, Stergios A. Pοlyzos, Evangelos Kazakos

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(5), P. 660 - 661

Published: July 30, 2024

LINKED CONTENT This article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18182 .

Language: Английский

Citations

2
Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH—Authors’ reply DOI Open Access
Sandeep Bansal, Meena B. Bansal

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(5), P. 662 - 663

Published: July 30, 2024

LINKED CONTENT This article is linked to Bansal et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18124 .

Language: Английский

Citations

1