Editorial: Revolutionising Steatotic Liver Disease Diagnosis With Phosphatidylethanol—Authors' Reply DOI Open Access
Federica Tavaglione, Rohit Loomba

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

We thank Ho and Mak for their positive comments on our recently published work, in which we demonstrate that phosphatidylethanol (PEth) is an accurate, quantitative, objective, blood-based alcohol biomarker diagnosing the newly defined metabolic dysfunction alcohol-related liver disease (MetALD) [1]. Leveraging a well-characterised United States (U.S.) cohort of 374 community-dwelling individuals with overweight or obesity steatotic (SLD) assessed through advanced magnetic resonance imaging (MRI) techniques [2], showed PEth exhibited robust diagnostic accuracy differentiating MetALD from dysfunction-associated (MASLD) (AUROC 0.81, 95% CI 0.73–0.89) optimal cut-off 25 ng/mL, outperformed indirect biomarkers, including aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, gamma glutamyltransferase (GGT), mean corpuscular volume (MCV) ALD/non-alcoholic fatty index (ANI). abnormal cellular membrane phospholipid formed human erythrocytes exclusively during ingestion. Specifically, synthesised phosphatidylcholine transphosphatidylation reaction catalysed by enzyme phospholipase D only presence ethanol (Figure 1) [3]. Given physiopathology underlying formation degradation, astutely highlighted factors such as anaemia, cirrhosis drinking patterns may significantly influence levels [4]. However, handful studies have specifically investigated impact these conditions levels. Limited evidence suggests elimination PEth, rather than its formation, be affected alter red blood cell turnover [3, 5, 6]. Additional research required to fully address questions. Regarding patterns, has shown potential identifying excessive episodes binge behaviours, but this area warrants further investigation SLD population 7]. Notably, another important question needs addressed clearly exact quantity must consumed over specific time period yield test In conclusion, body conducted medical settings outside SLD, screening emergency departments, detoxification programs, pre-employment examinations, transplant evaluation forensic context, demonstrated reliable detecting heavy consumption [7-9]. Our study represents initial effort within setting support objective subcategories enhancing subclassification alongside self-reported use. Despite promising findings, many critical questions remain larger more diverse studies. These include establishment thresholds corresponding variability degradation across different diseases patterns. Federica Tavaglione: writing – review editing, original draft. Rohit Loomba: draft, editing. The authors' declarations personal financial interests are unchanged those article This linked Tavaglione et al papers. To view articles, visit https://doi.org/10.1111/apt.18506 https://doi.org/10.1111/apt.18529. authors nothing report.

Language: Английский

Editorial: Revolutionising Steatotic Liver Disease Diagnosis With Phosphatidylethanol—Authors' Reply DOI Open Access
Federica Tavaglione, Rohit Loomba

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

We thank Ho and Mak for their positive comments on our recently published work, in which we demonstrate that phosphatidylethanol (PEth) is an accurate, quantitative, objective, blood-based alcohol biomarker diagnosing the newly defined metabolic dysfunction alcohol-related liver disease (MetALD) [1]. Leveraging a well-characterised United States (U.S.) cohort of 374 community-dwelling individuals with overweight or obesity steatotic (SLD) assessed through advanced magnetic resonance imaging (MRI) techniques [2], showed PEth exhibited robust diagnostic accuracy differentiating MetALD from dysfunction-associated (MASLD) (AUROC 0.81, 95% CI 0.73–0.89) optimal cut-off 25 ng/mL, outperformed indirect biomarkers, including aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, gamma glutamyltransferase (GGT), mean corpuscular volume (MCV) ALD/non-alcoholic fatty index (ANI). abnormal cellular membrane phospholipid formed human erythrocytes exclusively during ingestion. Specifically, synthesised phosphatidylcholine transphosphatidylation reaction catalysed by enzyme phospholipase D only presence ethanol (Figure 1) [3]. Given physiopathology underlying formation degradation, astutely highlighted factors such as anaemia, cirrhosis drinking patterns may significantly influence levels [4]. However, handful studies have specifically investigated impact these conditions levels. Limited evidence suggests elimination PEth, rather than its formation, be affected alter red blood cell turnover [3, 5, 6]. Additional research required to fully address questions. Regarding patterns, has shown potential identifying excessive episodes binge behaviours, but this area warrants further investigation SLD population 7]. Notably, another important question needs addressed clearly exact quantity must consumed over specific time period yield test In conclusion, body conducted medical settings outside SLD, screening emergency departments, detoxification programs, pre-employment examinations, transplant evaluation forensic context, demonstrated reliable detecting heavy consumption [7-9]. Our study represents initial effort within setting support objective subcategories enhancing subclassification alongside self-reported use. Despite promising findings, many critical questions remain larger more diverse studies. These include establishment thresholds corresponding variability degradation across different diseases patterns. Federica Tavaglione: writing – review editing, original draft. Rohit Loomba: draft, editing. The authors' declarations personal financial interests are unchanged those article This linked Tavaglione et al papers. To view articles, visit https://doi.org/10.1111/apt.18506 https://doi.org/10.1111/apt.18529. authors nothing report.

Language: Английский

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