MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

Cellular Oncology, Journal Year: 2017, Volume and Issue: 40(5), P. 457 - 470

Published: July 24, 2017

Language: Английский

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Targeted therapies in breast cancer: New challenges to fight against resistance

World Journal of Clinical Oncology, Journal Year: 2017, Volume and Issue: 8(2), P. 120 - 120

Published: Jan. 1, 2017

Breast cancer is the most common type of found in women and today represents a significant challenge to public health.With latest breakthroughs molecular biology immunotherapy, very specific targeted therapies have been tailored pathophysiology different types breast cancers.These recent developments contributed more efficient treatment protocol patients.However, main be further investigated still remains emergence therapeutic resistance mechanisms, which develop soon after onset therapy need urgent attention elucidation.What are emerging mechanisms what best strategies apply order circumvent this important obstacle?The scope review provide thorough update field discuss future prospects for preventing quest increase overall survival patients suffering from disease.

Language: Английский

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The Role of Curcumin in Cancer Treatment

Biomedicines, Journal Year: 2021, Volume and Issue: 9(9), P. 1086 - 1086

Published: Aug. 26, 2021

Curcumin is a polyphenol extracted from the rhizomes of turmeric plant, Curcuma longa which has anti-inflammatory, and anticancer properties. Chronic inflammation associated with development cancer. acts on regulation various immune modulators, including cytokines, cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), partly explains its effects. It also takes part in downregulation growth factors, protein kinases, oncogenic molecules signaling pathways, such as nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), c-Jun N-terminal kinase (JNK) signal transducer activator transcription 3 (STAT3) signaling. Clinical trials curcumin have been completed or are ongoing for types This review presents molecular mechanisms different cancer evidence most recent clinical trials.

Language: Английский

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Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells

Experimental and Therapeutic Medicine, Journal Year: 2018, Volume and Issue: unknown

Published: June 22, 2018

Curcumin is a natural compound that appears to be promising for clinical application, as it has been shown in vitro and vivo studies exert antitumor effects by modulating multiple signaling cellular pathways. In the present study, of curcumin its mechanism action were investigated cultured breast cancer cells. The MTT assay was used determine effect on cell proliferation, flow cytometry detect alterations cycle, western blot analysis expression molecules involved proliferation apoptosis. results revealed significantly inhibited various lines, such T47D, MCF7, MDA-MB-231 MDA-MB-468, with an IC50 at micromolar level, indicating potent activity curcumin. In-depth study induced cycle arrest G2/M phase decreased CDC25 CDC2 proteins, while increasing P21. addition, phosphorylation protein kinase B (Akt)/mammalian target rapamycin (mTOR), B-cell lymphoma 2 (BCL2) promoted BCL-2-associated X (BAX) cleavage caspase 3, subsequently inducing apoptosis conclusion, cells apoptosis, which may associated decrease increase P21 levels, well inhibition Akt/mTOR induction mitochondrial apoptotic pathway. findings provide basis further treatment cancer.

Language: Английский

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New and Emerging Targeted Therapies for Advanced Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2288 - 2288

Published: Feb. 18, 2022

In the United States, breast cancer is among most frequently diagnosed cancers in women. Breast classified into four major subtypes: human epidermal growth factor receptor 2 (HER2), Luminal-A, Luminal-B, and Basal-like or triple-negative, based on histopathological criteria including expression of hormone receptors (estrogen and/or progesterone receptor) HER2. Primary treatments can include surgery, radiation therapy, systemic chemotherapy, endocrine targeted therapy. Endocrine therapy has been shown to be effective receptor-positive a common choice for adjuvant However, due aggressive nature triple-negative cancer, becoming noteworthy area research search non-endocrine-targets cancer. addition HER2-targeted other emerging therapies immunotherapy against critical checkpoints pathways cell growth. This review summarizes novel explores possible implications combination

Language: Английский

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Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as crucial contributor development, advancement, resistance This review article explores implications of PI3K in predictive, preventive, personalized medicine for BC. It emphasizes identification predictive biomarkers, such PIK3CA mutations, utility profiling guiding treatment decisions. The also discusses potential targeting preventive strategies customization therapy based on tumor stage, subtypes, genetic alterations. Overcoming inhibitors exploring combination therapies are addressed important considerations. While this field holds promise improving patient outcomes, further research clinical trials needed validate these approaches translate them into practice. Graphical

Language: Английский

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Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2016, Volume and Issue: 1863(12), P. 2942 - 2976

Published: Sept. 10, 2016

Language: Английский

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Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen/aromatase inhibitors

Current Opinion in Pharmacology, Journal Year: 2018, Volume and Issue: 41, P. 59 - 65

Published: April 30, 2018

Language: Английский

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Milk’s Role as an Epigenetic Regulator in Health and Disease

Diseases, Journal Year: 2017, Volume and Issue: 5(1), P. 12 - 12

Published: March 15, 2017

It is the intention of this review to characterize milk’s role as an epigenetic regulator in health and disease. Based on translational research, we identify milk a major modulator gene expression recipient. Milk presented “doping system” mammalian development. exosome-derived micro-ribonucleic acids (miRNAs) that target DNA methyltransferases are implicated play key upregulation developmental genes such FTO, INS, IGF1. In contrast miRNA-deficient infant formula, breastfeeding via physiological miRNA transfer provides appropriate signals for adequate programming newborn infant. Whereas restricted lactation period, continued consumption cow’s results persistent critically involved development diseases civilization diabesity, neurodegeneration, cancer. We hypothesize same miRNAs epigenetically increase lactation, upregulate recipient milk-derived miRNAs. critical concern pasteurized contaminates human food chain with bovine miRNAs, identical their analogs. Commercial interest enhance dairy performance may further burden consumer.

Language: Английский

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Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms

Journal of Hematology & Oncology, Journal Year: 2019, Volume and Issue: 12(1)

Published: April 11, 2019

Breast cancer is the most common malignancy in women all over world. Genetic background of contributes to her risk having breast cancer. Certain inherited DNA mutations can dramatically increase developing certain cancers and are responsible for many that run some families. Regarding widespread multigene panels, whole exome sequencing capable providing evaluation genetic function development novel strategy clinical trials. Targeting mutant proteins involved be an effective therapeutic approach drugs. This systematic review discusses gene linked cancer, focusing on signaling pathways being targeted with investigational strategies, where trials could potentially initiated future highlighted.

Language: Английский

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