Welcome to Basic & Clinical Pharmacology & Toxicology 2024 DOI
Ulf Simonsen, Jens Lykkesfeldt

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2023, Volume and Issue: 134(1), P. 126 - 128

Published: Dec. 12, 2023

Language: Английский

Older Adults’ Attitudes Toward Deprescribing in 14 Countries DOI Creative Commons
Renata Vidonscky Lüthold, Katharina Tabea Jungo, Kristie Rebecca Weir

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2457498 - e2457498

Published: Feb. 10, 2025

Importance Better understanding of patients’ attitudes toward deprescribing specific medications will inform future interventions. Objective To investigate older adults’ by investigating which they would like to have deprescribed, the reasons why, and patient factors associated with interest in deprescribing. Design, Setting, Participants This survey study was conducted from May 2022 December 2023 primary care settings 14 countries. Patients aged 65 years or taking 5 more were consecutively recruited their general practitioner (GP) completed questionnaire. Exposures Patient characteristics, including gender, number medications, GP education level, financial status, confidence completing medical forms, self-rated health, satisfaction trust GP, country. Main Outcomes Measures The outcomes as measured responses question, “Thinking about your current medication list, are there any that you stop reduce dose of?” Multilevel multivariable logistic regression analysis used, adjusted for clustering effect at country association between characteristics Results Of 1340 patients (mean [SD], 96 [47] per country), 736 (55%) women, 580 (44%) had secondary school highest level education, 1089 (82%) satisfied 589 expressed deprescribe 1 medications. varying levels, 79% (86 109 patients) Poland 23% (21 Bulgaria. 3 most reported deprescribed diuretics (111 1002 [11%]), lipid-modifying agents (109 acting on renin-angiotensin system (83 [8%]). odds naming least lower higher (odds ratio, 0.31; 95% CI, 0.21-0.47) 0.960; 0.930-0.998). Conclusions Relevance In this older, varied across countries, demonstrating interventions could be impactful when adapted contexts. These findings highlight importance patient-practitioner communication ensuring appropriate use.

Language: Английский

Citations

1

Patterns of outpatient proton‒pump inhibitors use among older adults in a duplicative health system: comparing public and private prescribing DOI Creative Commons

S Romano,

António Teixeira Rodrigues, Carla Torre

et al.

BMC Health Services Research, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 6, 2025

Proton-pump-inhibitors (PPIs) are overprescribed, posing challenges to patients and healthcare systems. In Portugal, the public National Health Service (NHS) provides universal coverage reimburses medication regardless of prescription origin, i.e., or private. This study aimed compare PPIs outpatient patterns costs among older adults in private sectors. A nationwide retrospective ecological was conducted on prescribed for Portugal from 2020–2022. Data defined daily doses (DDDs) prices were obtained a national database by sector, sex, age group (65–74, ≥ 75 years). The market share DDD per 1000 day mean price (€/DDD) all substances compared between PPIs-DDDs accounted 5.3% DDDs sector 5.9% sector. at 20% higher (0.126 €/DDD) than (0.106 €/DDD), with greater differences most expensive (rabeprazole, lansoprazole esomeprazole). Omeprazole (cheapest) mostly similar pattern observed those aged years, whereas esomeprazole 65–74 years. Given widespread associated cost, it is crucial reinforce incentives promote rational encourage deprescription when necessary, both Since NHS also medications units, implementing monitoring measures financial responsible prescribing this should be considered.

Language: Английский

Citations

0

Impact of land use characteristics on air pollutant concentrations considering the spatial range of influence DOI
Gunwon Lee, Han Yuhan, Geunhan Kim

et al.

Atmospheric Pollution Research, Journal Year: 2025, Volume and Issue: unknown, P. 102498 - 102498

Published: March 1, 2025

Language: Английский

Citations

0

Influence of chronic medical conditions on older patients’ willingness to deprescribe medications: a cross-sectional study DOI Creative Commons
Anabela Pereira, Manuel Teixeira Veríssimo, Óscar Ribeiro

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 4, 2024

Aging correlates with a heightened prevalence of chronic diseases, resulting in multimorbidity affecting 60% those aged 65 or older. Multimorbidity often leads to polypharmacy, elevating the risk potentially inappropriate medication (PIM) use and adverse health outcomes. To address these issues, deprescribing has emerged as patient-centered approach that considers patients' beliefs attitudes toward reduces polypharmacy older adults. Our study aims investigate whether certain medical conditions are associated willingness deprescribe medications.

Language: Английский

Citations

3

Attitudes towards deprescribing in geriatric psychiatry: A survey among older psychiatric outpatients DOI Creative Commons
Carina Lundby,

Marianne Nielsen,

Trine Simonsen

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2023, Volume and Issue: 134(1), P. 97 - 106

Published: Oct. 12, 2023

Understanding the patient perspective is a significant part of deprescribing process. This study aimed to explore attitudes older patients with psychiatric disorders towards deprescribing. A total 72 outpatients (68% women; median age 76 years) completed validated Danish version revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire. Patients used eight medications (interquartile range 6-12), 88%, 49% and 24% using antidepressants, antipsychotics anxiolytics, respectively. Fifty-one percent reported an intrinsic desire stop one their medications, while 92% would be willing on physician's advice. Seventy-five worried about missing out future benefits following 37% had previous bad experiences. Use ≥8 regular was associated more concerns stopping medication greater perceived burden medication, use not any differences in rPATD factor scores. It crucial for health care professionals aware patients' specific past experiences promote patient-centred approach that takes into account needs preferences disorders.

Language: Английский

Citations

5

Advancing deprescribing: Learnings from the first international conference on deprescribing DOI
Carina Lundby, Wade Thompson

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2023, Volume and Issue: 134(1), P. 3 - 5

Published: Nov. 21, 2023

There are no conflicts to declare. Research data not shared.

Language: Английский

Citations

4

Deprescribing in Older Adults: Attitudes, Awareness, Training, and Clinical Practice Among Portuguese Physicians DOI Creative Commons
Anabela Pereira, Manuel Teixeira Veríssimo, Óscar Ribeiro

et al.

Acta Médica Portuguesa, Journal Year: 2024, Volume and Issue: 37(10), P. 684 - 696

Published: Oct. 1, 2024

The importance of deprescribing in clinical practice is growing, particularly aging populations with polypharmacy scenarios, making it a crucial matter Portugal, one Europe's most aged nations. aim this study was to investigate awareness, training, attitudes, and practices among Portuguese physicians inform future healthcare strategies.

Language: Английский

Citations

1

Are Saudi Arabian Patients Willing to Be Deprescribed Their Medications? An Exploratory Study DOI Creative Commons
Sultana A. Alhurishi,

M N Alqahtani

Patient Preference and Adherence, Journal Year: 2024, Volume and Issue: Volume 18, P. 779 - 786

Published: March 1, 2024

Purpose: Deprescribing is a complex process that requires active patient involvement, so the patient's attitude to deprescribing crucial its success.This study aimed assess predictors of Saudi Arabian patients' willingness deprescribe.Patients and Methods: In this cross-sectional study, adult patients from two hospitals in Riyadh completed self-administered questionnaire gathering data on demographic information Arabic revised Patients' Attitudes Towards (rPATD) questions.Descriptive analysis binary logistic regression were used analyze data.Results: A total 242 included (mean age 59.8 (SD 11.05) years, range 25-87 years; 40% 60-69 54.1% female).The majority (90%) participants willing have medications deprescribed.Willingness deprescribe was significantly associated with rPATD involvement factor (OR=1.866, 95% CI 1.177-2.958,p=0.008) perception their health status (OR=2.08,CI=1.058-4.119,p=0.034). Conclusion:The one or more deprescribed if recommended by doctors.Patient perceptions about own important predictive factors could shape counseling education strategies encourage deprescribing.

Language: Английский

Citations

0

Attitudes and beliefs towards medication burden and deprescribing in Parkinson disease DOI Creative Commons
Thanh Phuong Pham Nguyen,

Dylan Thibault,

Ali G. Hamedani

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 6, 2024

Language: Английский

Citations

0

Predictors of medicine-related perceptions towards deprescribing inappropriate medications among older adult outpatients in Jordan: a cross-sectional study DOI Creative Commons
Mohammad Rababa,

Ali Al Ghazo,

Audai A. Hayajneh

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e086207 - e086207

Published: Nov. 1, 2024

Objectives To examine the predictors of medicine-related perceptions towards deprescribing inappropriate medications among older adults in Jordan. Design A cross-sectional, correlational study. Setting Data were collected by a graduate nursing student from five outpatient clinics selected public hospital Jordan via inperson interviews 5 days week over period 4 months. Participants convenience sample 200 who regularly visited for regular check-ups during July 2023 recruited. Outcome measures Predictors patients’ perceived medication concerns, interest stopping medications, unimportance and beliefs about overuse examined. Results Increased concerns patients significantly associated with age (p=0.037), lower level self-rated general health (p=0.002), less care-provider knowledge (p=0.041), higher medicines (p=0.018), collaboration care providers (p=0.017), being seen clinical pharmacist (p<0.001) an increased number prescribed (p<0.001). was levels (p=0.029), involvement decision-making (p=0.013), (p=0.024) (p=0.001). Furthermore, more (p=0.007), (p=0.001) greater Moreover, (p=0.016), (p=0.038), having post-traumatic disorder (p=0.018) (p=0.038). Conclusions The current study examined adults. Care should discuss benefits their to prevent side effects long-term unnecessary use. Future studies on effectiveness evidence-based protocol minimising prescription are recommended.

Language: Английский

Citations

0