Type II Opsins in the Eye, the Pineal Complex and the Skin of Xenopus laevis: Using Changes in Skin Pigmentation as a Readout of Visual and Circadian Activity DOI Creative Commons
Gabriel E. Bertolesi,

Nilakshi Debnath,

Hannan R. Malik

et al.

Frontiers in Neuroanatomy, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 21, 2022

The eye, the pineal complex and skin are important photosensitive organs. African clawed frog, Xenopus laevis , senses light from environment adjusts color accordingly. For example, reflected surface induces camouflage through background adaptation while above produces circadian variation in pigmentation. During embryogenesis, adaptation, segregated responses regulated by secretion of α-melanocyte-stimulating hormone (α-MSH) melatonin photosensitivity eye complex, respectively. Changes pigmentation have been used as a readout biochemical physiological processes since initial purification pigs, more recently employed to better understand neuroendocrine circuit that regulates adaptation. identification 37 type II opsin genes genome allotetraploid X. combined with analysis their expression skin, is contributing elucidation role opsins different organs, but also brings new questions challenges. In this review, we analyze findings regarding anatomical localization functions sensing light. contribution revealing circuits regulate changes discussed. Finally, presence melanophores presented compared secretory melanocytes birds mammals.

Language: Английский

Expression and Mutation of <i>SLC45A2</i> Affects Iris Color in Quail DOI Creative Commons

Linke Huo,

Xiao Hui Zhang, Youzhi Pang

et al.

The Journal of Poultry Science, Journal Year: 2024, Volume and Issue: 61(0), P. n/a - n/a

Published: Jan. 1, 2024

Iris color is a prominent phenotypic feature of quail. To understand the mechanism melanin deposition related to quail iris color, tissues were selected from Beijing white and Chinese yellow for transcriptome analysis. Differentially expressed genes (DEGs) associated with pigmentation identified using RNA sequencing validated by quantitative real-time polymerase chain reaction (RT-qPCR). The single nucleotide polymorphisms studied bioinformatics correlation analyses. A total 485 DEGs obtained, 223 upregulated 262 downregulated. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes pathway enrichment analyses performed. Thirty-two annotated GO database. Three important pigment synthesis pathways (Notch signaling, melanogenesis, tyrosine metabolism) in tissue (P < 0.05). expression levels solute carrier family 45 member 2 (SLC45A2), tyrosinase-related protein 1, vitamin D receptor, opsin 5, docking 5 significantly different between quail, as verified RT-qPCR. c.1061C>T mutation SLC45A2, which caused amino acid change at position 354 (threonine methionine), was might be main reason colors these two species.

Language: Английский

Citations

1
OPN3 Regulates Melanogenesis in Human Congenital Melanocytic Nevus Cells through Functional Interaction with BRAFV600E DOI Creative Commons
Xian Dong, Wen Zeng, Wei Zhang

et al.

Journal of Investigative Dermatology, Journal Year: 2022, Volume and Issue: 142(11), P. 3020 - 3029.e5

Published: May 14, 2022

Language: Английский

Citations

6
Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells DOI Open Access

Min Chang Oh,

Pincha Devage Sameera Madushan Fernando,

Mei Jing Piao

et al.

Journal of Cancer Prevention, Journal Year: 2023, Volume and Issue: 28(2), P. 40 - 46

Published: June 30, 2023

Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- α-MSH-induced melanin production attenuated tyrosinase (monophenol monooxygenase) activity, expression tyrosine-related protein-2. In addition, melanogenesis pigmentation p38 mitogen-activated protein kinases signaling pathway. These findings suggest that represents a natural compound for attenuating

Language: Английский

Citations

2
Molecular Property, Manipulation, and Potential Use of Opn5 and Its Homologs DOI Open Access
Keita Sato, Hideyo Ohuchi

Journal of Molecular Biology, Journal Year: 2023, Volume and Issue: 436(5), P. 168319 - 168319

Published: Oct. 20, 2023

Language: Английский

Citations

2
Type II Opsins in the Eye, the Pineal Complex and the Skin of Xenopus laevis: Using Changes in Skin Pigmentation as a Readout of Visual and Circadian Activity DOI Creative Commons
Gabriel E. Bertolesi,

Nilakshi Debnath,

Hannan R. Malik

et al.

Frontiers in Neuroanatomy, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 21, 2022

The eye, the pineal complex and skin are important photosensitive organs. African clawed frog, Xenopus laevis , senses light from environment adjusts color accordingly. For example, reflected surface induces camouflage through background adaptation while above produces circadian variation in pigmentation. During embryogenesis, adaptation, segregated responses regulated by secretion of α-melanocyte-stimulating hormone (α-MSH) melatonin photosensitivity eye complex, respectively. Changes pigmentation have been used as a readout biochemical physiological processes since initial purification pigs, more recently employed to better understand neuroendocrine circuit that regulates adaptation. identification 37 type II opsin genes genome allotetraploid X. combined with analysis their expression skin, is contributing elucidation role opsins different organs, but also brings new questions challenges. In this review, we analyze findings regarding anatomical localization functions sensing light. contribution revealing circuits regulate changes discussed. Finally, presence melanophores presented compared secretory melanocytes birds mammals.

Language: Английский

Citations

3