Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall

Journal of Hematopathology, Journal Year: 2023, Volume and Issue: 16(2), P. 127 - 128

Published: April 10, 2023

We report the case of a 66-year-old man with known history IgD multiple myeloma (MM) which was admitted to hospital because acute renal failure. Routine PCR testing on admission yielded positive result for SARS-CoV-2 infection. Examination peripheral blood (PB) smear revealed 17% lymphoplasmacytoid cells and few small plasma mimicking morphological changes frequently seen in viral diseases. However, flow cytometric examination showed 20% clonal lambda-restricted being consistent diagnosis secondary cell leukemia. Circulating as well similar appearing lymphocyte subtypes such plasmacytoid lymphocytes are observed infectious disorders COVID-19, so that morphology our patient's could have been easily misinterpreted typical COVID-19-induced changes. Our observation highlights importance incorporating clinical, morphological, flow-cytometric data distinguishing between reactive neoplastic misinterpretation may affect disease classification and, beyond that, clinical decision-making, serious consequences patients.

Language: Английский

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Adolescent with severe coronavirus disease 2019 (COVID‐19): A hematology laboratory perspective

Pediatric Pulmonology, Journal Year: 2023, Volume and Issue: 58(8), P. 2389 - 2390

Published: May 22, 2023

Language: Английский

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Neutrophil and eosinophil extracellular traps in intensive care unit Covid patients' peripheral smears

International Journal of Laboratory Hematology, Journal Year: 2023, Volume and Issue: 45(6), P. 995 - 998

Published: July 19, 2023

The data that support the findings of this study are available from first and corresponding author upon reasonable request. Table S1: Laboratory at intensive care admission outcome. WBC: white blood cell; LDH: lactate dehydrogenase. Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to article.

Language: Английский

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Alteraciones en los parámetros hematológicos y anormalidades morfológicas en células sanguíneas en pacientes hospitalizados con COVID-19.

Revista Hematología, Journal Year: 2023, Volume and Issue: 27(2)

Published: Aug. 30, 2023

Antecedentes. La enfermedad por coronavirus (COVID-19) causada el virus SARS-CoV-2, ha originado una crisis de salud pública mundial y presenta un importante impacto sobre sistema hematopoyético. Objetivo. Describir las alteraciones en los parámetros hematológicos anomalías morfológicas células sanguíneas pacientes hospitalizados con COVID-19. Materiales métodos. Se realizó estudio transversal basado la revisión 133 hemogramas frotis sangre periférica mayores 18 años COVID-19 entre enero marzo del 2021 Hospital Cayetano Heredia, Lima, Perú. El recuento se mediante hemograma morfología sanguíneo utilizando técnica tinción Wright. análisis descriptivo frecuencias. Resultados. 60,9% (n=81) fueron sexo masculino. En hemograma, más frecuentes neutrofilia (65,4%), anemia (64,7%), leucocitosis (60,9%), linfopenia (59,4%), eosinopenia (51,9%) trombocitosis (27,8%). hematíes, anisocitosis (18,8%) fue alteración frecuente. A nivel leucocitaria, observamos granulaciones tóxicas (51,1%), hipersegmentación neutrófilos (32,3%), linfocitos reactivos (15%) anomalía adquirida Pelger Hüet (APHA) (9%) y, a plaquetario, plaquetas gigantes (33,8%) observada. Conclusiones. Nuestro describe variedad

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