Aspergillus flavus with Mycovirus as an Etiologic Factor for Acute Leukemias in Susceptible Individuals: Evidence and Discussion
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 488 - 488
Published: Feb. 17, 2025
Several
etiologic
factors
for
the
development
of
acute
leukemias
have
been
suggested;
however,
none
is
applicable
to
all
cases.
We
isolated
a
certain
mycovirus-containing
Aspergillus
flavus
(MCAF)
from
home
patient
with
lymphoblastic
leukemia.
Repeated
electron
microscopic
evaluations
proved
existence
mycovirus
in
this
organism.
According
chemical
analysis,
organism
does
not
produce
any
aflatoxin,
possibly
due
its
infestation
mycoviruses.
reported
that
using
ELISA
technique,
forty
pediatric
patients
leukemia
(ALL)
uniformly
had
antibodies
products
MCAF.
In
contrast,
three
separate
groups
controls,
consisting
normal
blood
donors,
individuals
solid
tumors,
and
sickle
cell
disease,
were
negative.
vitro
exposure
mononuclear
cells
ALL,
full
remission,
MCAF
induced
redevelopment
surface
phenotypes
genetic
markers
characteristic
ALL.
The
controls
incubation
ALL
lines
resulted
significant
cellular
apoptosis,
changes
cycle,
downregulation
transcription
factors,
including
PAX-5
Ikaros
(75
55
kDa).
Fungi
are
widespread
nature,
many
contain
Normally,
an
individual
inhales
1
10
fungal
spores
per
minute,
while
farmers
can
inhale
up
75,000
minute.
It
known
foresters,
who
more
exposed
fungi,
higher
rate
asthmatics,
most
whom
allergic
agents,
working
office
settings
lower
rate.
One
theories
suggests
predisposition
followed
by
infectious
agent.
With
above
findings,
we
propose
may
etiological
role
leukemogenesis
immune-depressed
genetically
susceptible
individuals.
Language: Английский
Genetic Diversity in KMT2A‐r and KMT2A‐Wt Groups: Assessing the Prognostic Value of Markers in BCP‐ALL Among Infants
International Journal of Laboratory Hematology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
ABSTRACT
Background/Objectives
Infant
BCP‐ALL
is
classified
into
KMT2A
‐r
and
‐wt
groups,
both
showing
heterogeneity.
rearrangements
indicate
poor
prognosis,
but
outcomes
vary
by
fusion
partner.
The
group
includes
cases
in
the
B‐other
ALL
subgroup,
with
unclear
prognostic
significance.
We
aim
to
improve
understanding
of
molecular
subtypes
‐wt,
focusing
on
NUTM1
PAX5
rearrangements.
Methods
analyzed
175
infants
(aged
0–365
days)
diagnosed
from
2010
2023
at
Dmitry
Rogachev
National
Medical
Research
Center
Pediatric
Hematology,
Oncology
Immunology.
Genomic
aberrations
were
identified
karyotyping,
FISH
RNA‐seq.
RNA‐seq
was
performed
using
Illumina,
gene
fusions
validated
Sanger
sequencing.
Results
There
no
difference
survival
based
partner
genes.
KMT2A::AFF1
showed
similar
other
partners,
2‐year
EFS
36%
(95%
CI,
21%–59%)
versus
37%
23%–60%)
(log‐rank
test,
p
=
0.9).
In
(
n
33,
17.7%
cases),
NUTM1‐r
9)
PAX5‐r
10)
accounted
for
27%
30.3%,
respectively.
groups
excellent
rates,
80%
52%–100%)
100%
100%–100%),
respectively,
small
cohort
size
limit
statistical
power
analysis
Conclusions
Survival
did
not
differ
a
favorable
‐rearranged
patients
had
better
than
previously
reported.
group,
most
common
fusion,
BRD9:NUTM1
,
variability
breakpoints
(Exons
3,
8,
14
BRD9
).
Language: Английский