Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Language: Английский
Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)
Published: June 21, 2023
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality is morphologically and mechanistically different from other forms of death, plays vital role in the pathophysiological process neurodegenerative diseases, strokes. Accumulating supports ferroptosis as critical factor diseases strokes, pharmacological inhibition therapeutic target for these diseases. In this review article, core mechanisms are overviewed roles strokes described. Finally, emerging findings treating through This demonstrates by bioactive small-molecule compounds (ferroptosis inhibitors) could be effective treatments highlights potential promising avenue used to prevent article will shed light on developing novel regimens slow down progression future.
Language: Английский
Citations
83
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Dec. 10, 2023
Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt
Language: Английский
Citations
77
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Language: Английский
Citations
56
Experimental Neurology, Journal Year: 2023, Volume and Issue: 372, P. 114630 - 114630
Published: Dec. 4, 2023
Language: Английский
Citations
35
European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 957, P. 175979 - 175979
Published: Aug. 21, 2023
Cerebral ischemia/reperfusion injury (CIRI) seriously threatens human life and health. Scutellarin (Scu) exhibits neuroprotective effects, but little is known about its underlying mechanism. Therefore, we explored protective effect on CIRI the Our results demonstrated that Scu rescued HT22 cells from cytotoxicity induced by oxygen glucose deprivation/reoxygenation (OGD/R). also showed antioxidant activity promoting nuclear factor erythroid 2-related 2 (Nrf2) translocation, upregulating heme oxygenase-1 (HO-1) expression, increasing superoxide dismutase (SOD) activity, inhibiting reactive species (ROS) generation in vitro. Additionally, reduced factor-kappa B (NF-κB) levels of pro-inflammatory factors. Interestingly, these effects were abolished Nrf2 inhibition. Furthermore, infarct volume blood-brain barrier (BBB) permeability, improved sensorimotor functions depressive behaviors, alleviated oxidative stress neuroinflammation rats subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). Mechanistically, Scu-induced accumulation inactivation NF-κB accompanied an enhanced level phosphorylated protein kinase (p-AKT) both vitro vivo. Pharmacologically phosphatidylinositol-3-kinase/protein (PI3K/AKT) pathway blocked translocation NF-κB, as well anti-inflammatory activities. In summary, suggest antioxidant, anti-inflammatory, through activation mediated PI3K/Akt pathway.
Language: Английский
Citations
30
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(3), P. 611 - 618
Published: July 20, 2023
Abstract Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation lipid peroxides, imbalance in amino acid antioxidant system, disordered iron metabolism. The primary organelle responsible for coordinating external challenges internal demands endoplasmic reticulum, progression inflammatory diseases can trigger reticulum stress. Evidence has suggested that ferroptosis may share pathways or interact with stress many plays role survival. occur after ischemic stroke. However, there are few reports on interactions This review summarized recent research relationships between stroke, aiming to provide reference developing treatments
Language: Английский
Citations
28
Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7173 - 7173
Published: Oct. 19, 2023
Epimedium is a classical Chinese herbal medicine, which has been used extensively to treat various diseases, such as sexual dysfunction, osteoporosis, cancer, rheumatoid arthritis, and brain diseases. Flavonoids, icariin, baohuoside I, icaritin, epimedin C, are the main active ingredients with diverse pharmacological activities. Currently, most flavonoids extracted from plants, but this method cannot meet increasing market demand. Biotransformation strategies promised huge potential for contents of high-value flavonoids, would promote full use herb. Complete biosynthesis major by microbial cell factories enable industrial-scale production flavonoids. This review summarizes structures, activities, pathways in plant, well extraction methods advancements biotransformation complete synthesis provide valuable insights future studies on herb usage
Language: Английский
Citations
27
Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)
Published: Feb. 23, 2024
Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related ferroptosis. The mechanisms ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide as well glutathione amino acid metabolism. What's more, the causal relationship between IS elucidated by several processes. disruption blood-brain barrier, release excitatory acids, inflammatory response after all lead disorder metabolism antioxidant system. Based on these statements, we reviewed reported effects compounds drugs treating modulating key molecules in Through detailed analysis roles molecules, have also more clearly demonstrated essential effect occurrence so provide new targets ideas for therapeutic IS.
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 891 - 891
Published: Jan. 10, 2024
Stroke is a major cause of death and disability worldwide. Endovascular thrombectomy has been impactful in decreasing mortality. However, many clinical results continue to show suboptimal functional outcomes despite high recanalization rates. This gap symptomatic improvement suggests need for adjunctive therapies post-thrombectomy care. With greater insight into ischemia-reperfusion injury, recent preclinical testing neuroprotective agents shifted towards preventing oxidative stress through upregulation antioxidants downstream effectors, with positive results. Advances multiple therapies, including uric acid, activated protein C, nerinetide, otaplimastat, imatinib, verapamil, butylphthalide, edaravone, nelonemdaz, ApTOLL, regional hypothermia, remote ischemic conditioning, normobaric oxygen, especially nuclear factor erythroid 2-related 2, have promising evidence improving stroke Sedation blood pressure management endovascular also play crucial roles improved outcomes. A hand-in-hand approach both therapy neuroprotection may be the key targeting due stroke.
Language: Английский
Citations
14
Phytochemistry, Journal Year: 2024, Volume and Issue: 219, P. 114002 - 114002
Published: Jan. 27, 2024
Language: Английский
Citations
13