A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: 202, P. 13 - 23

Published: March 6, 2025

Inflammasomes are multiprotein complexes of the innate immune system that mediate inflammatory responses to infection and local systemic stress tissue injury. The principal function is facilitate caspase-1 auto-activation subsequently maturation release effectors interleukin (IL)-1β IL-18. atrial-specific NLRP3 inflammasome a unifying causal feature atrial fibrillation (AF) development, progression recurrence after ablation. Many AF-associated risk factors co-morbidities converge mechanistically on activation this central signaling platform. This review presents historical conceptual development distinct its potential involvement in AF. We follow early observations linking inflammation with AF, emergence an atrial-intrinsic operating within not just cells but also resident fibroblasts cardiomyocytes. outline key developments understanding how effector IL-1β contribute causally cellular tissue-level arrhythmogenesis different pathological settings, candidate therapeutic concepts verified preclinical models cardiomyopathy

Language: Английский

Inhibition of the NLR pathway alleviates MAPK1 mutation-driven proliferation and differentiation deficits and enhanced apoptosis in P19 cells

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102973 - 102973

Published: May 1, 2025

Language: Английский

A Short History of the Atrial Nlrp3 Inflammasome and its Distinct Role in Atrial Fibrillation

Published: Jan. 1, 2024

Language: Английский