Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies DOI Creative Commons
Ademola C. Famurewa, Roland Eghoghosoa Akhigbe,

Mina Y. George

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Language: Английский

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments DOI Creative Commons
Bowen Yin, Jingyi Ren, Xuanyi Liu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 21, 2025

Background Doxorubicin (DOX), a widely employed chemotherapeutic agent in cancer treatment, has seen restricted use recent years owing to its associated cardiotoxicity. Current reports indicate that doxorubicin-induced cardiotoxicity (DIC) is complex phenomenon involving various modes of cell death. Astaxanthin (ASX), natural carotenoid pigment, garnered significant attention for numerous health benefits. Recent studies have shown ASX broad and effective cardiovascular protective effect. Our study aims investigate the effects against DIC elucidate underlying mechanisms. This substantial practical significance clinical application DOX. Methods Bioinformatic analyses were conducted using transcriptomic data from gene expression omnibus (GEO) database identify key mechanisms DIC. Network pharmacology was predict potential pathways targets through which exerts on In vitro experiments, following pretreatment with ASX, H9C2 cells exposed Cell viability, injury protein levels ferroptosis autophagy assessed. animal rats underwent 4 weeks gavage treatment doses followed by intraperitoneal injections DOX every 2 days during final week. Histological, serum, evaluate Results The bioinformatics analysis revealed are closely development may exert an anti-DIC effect modulating autophagy. experimental results show significantly mitigates DOX-induced myocardial tissue damage, inflammatory response, oxidative stress, damage cells. Mechanistically, markedly ameliorates both vivo . Specifically, upregulates solute carrier family 7 member 11 (SLC7A11) glutathione peroxidase (GPX4), while downregulating transferrin receptor 1 (TFRC), ferritin heavy chain (FTH1) light (FTL). Additionally, enhances P62 decreases Beclin1 microtubule-associated proteins 3 (LC3). Conclusion critical factors influencing occurrence progression can alleviate inhibiting

Language: Английский

Citations

1
Spexin (Neuropeptide Q): Distribution, Functional Roles, and Emerging Therapeutic Perspectives DOI

Ritesh S. Tarwani,

Kamini R. Shirasath,

Sanjay N. Awathale

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Jan. 8, 2025

Language: Английский

Citations

0
Astemizole Exacerbates 5-Fluorouracil-Triggered Cardiotoxicity by Enhancing Ptgs2 DOI

Mengshi Xie,

Pan Jiang, Xiyang Yang

et al.

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

0
Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects DOI Creative Commons
Qin Ru, Yusheng Li, Feng Zhang

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 25, 2025

Abstract The muscular system plays a critical role in the human body by governing skeletal movement, cardiovascular function, and activities of digestive organs. Additionally, muscle tissues serve an endocrine function secreting myogenic cytokines, thereby regulating metabolism throughout entire body. Maintaining requires iron homeostasis. Recent studies suggest that disruptions ferroptosis, form iron-dependent cell death, are essential contributors to progression wide range diseases disorders, including sarcopenia, cardiomyopathy, amyotrophic lateral sclerosis. Thus, comprehensive overview mechanisms ferroptosis these conditions is crucial for identifying potential therapeutic targets developing new strategies disease treatment and/or prevention. This review aims summarize recent advances understanding molecular underlying context injury, as well associated disorders. Moreover, we discuss within pathway possible managing Finally, shed light on current limitations future prospects interventions targeting ferroptosis.

Language: Английский

Citations

0
Herbacetin as a Novel Ferroptosis Inhibitor for Mitigating Myocardial Damage Induced by Doxorubicin DOI
Hai Yang, Shaohong Huang,

Xinyu Heng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Anti‐Inflammatory Effects of Spexin on Acetic Acid‑Induced Colitis in Rats via Modulating the NF‐κB/NLRP3 Inflammasome Pathway DOI Creative Commons
Sevil Arabacı Tamer, Fadime Köse, Sevinç Yanar

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(5)

Published: May 1, 2025

ABSTRACT Ulcerative colitis is a chronic inflammatory bowel disease characterized by inflammation and ulcers in the lining of colon rectum. Spexin novel peptide with antioxidant anti‐inflammatory properties. This study aims to elucidate therapeutic effects underlying mechanisms spexin mitigating acetic acid‐induced rats. Male Sprague Dawley rats were assigned control ( n = 14) 21) groups. Colitis was induced via 5% acid (AA) administration (1 mL, intrarect). Post‐induction, received subcutaneous saline mL/kg), (50 µg/kg/day), or oral sulfasalazine (500 mg/kg) for 5 days. Control groups spexin. After 24 h final treatment, colons evaluated macroscopically, levels tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐18 determined ELISA, oxidative stress markers myeloperoxidase (MPO), malondialdehyde (MDA) glutathione (GSH) measured spectrophotometrically NOD‐like receptor pyrin domain‐containing 3 (NLRP3), nuclear factor‐κB (NF‐κB), caspase‐1 proteins analyzed Western Blot alongside histopathological assessments. induction significantly elevated macroscopic damage scores, stool consistency, cytokines, MDA, MPO, NLRP3, NF‐κB, caspase‐1, while reducing GSH p < 0.001–0.01). Microscopic evaluations confirmed increased necrosis, submucosal edema, cell infiltration 0.001). reversed these enhancing 0.01), macroscopic/microscopic MPO 0.05–0.001), suppressing activation 0.01–0.001). For first time that ameluates modulating NF‐κB/NLRP3 signaling pathway, damage, capacity, inflammation.

Language: Английский

Citations

0
Empagliflozin attenuates DOX-induced cardiotoxicity by inhibiting RIPK1-mediated endoplasmic reticulum stress and autophagy DOI
Yinan Wang, Zi Wang,

Xinning Guo

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167898 - 167898

Published: May 1, 2025

Language: Английский

Citations

0
Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy DOI
Hong Deng, Jiayu Chen, Huimin Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 123123 - 123123

Published: Dec. 6, 2024

Language: Английский

Citations

0
Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies DOI Creative Commons
Ademola C. Famurewa, Roland Eghoghosoa Akhigbe,

Mina Y. George

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Language: Английский

Citations

0