DDR1 Targeting HOXA6 Facilitates Bladder Cancer Progression via Inhibiting Ferroptosis DOI Creative Commons
Xin Xie, Hongchao He, Ning Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(6)

Published: March 1, 2025

ABSTRACT Ferroptosis is an important factor affecting the progression of bladder cancer (BC). Previous studies have confirmed that discoidin domain receptor 1 (DDR1) promotes BC progression. However, regulatory mechanisms ferroptosis are largely unknown. Therefore, this study aimed to investigate effects DDR1 on cell ferroptosis. Ferroptosis‐sensitive and ‐resistant cells were screened, reverse‐transcription quantitative PCR western blotting used determine expression in cells. In vitro vivo assays performed analyse The inducer erastin inhibited TCCSUP inhibitor ferrostatin‐1 death caused by knockdown. increased glutathione, glutathione peroxidase 4 solute carrier family 7 member 11 expression, while decreasing malondialdehyde Fe 2+ levels acyl‐CoA synthetase long‐chain inhibiting epithelial mesenchymal transition neurofibromin 2‐yes‐associated protein. These abrogated knockdown homeobox A6 (HOXA6). targeting HOXA6 facilitated growth vivo. HOXA6. Thus, may serve as a potential therapeutic target for BC.

Language: Английский

Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment DOI Creative Commons
Haojie Wang, Yuanyuan Xie

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 334 - 334

Published: Feb. 26, 2025

In recent years, ferroptosis, as an emerging modality of programmed cell death, has captured significant attention within the scientific community. This comprehensive review meticulously canvasses pertinent literature past few spanning multiple facets. It delves into intricate mechanisms underpinning tracks evolution its inducers and inhibitors, dissects roles in a diverse array diseases, well resultant therapeutic implications. A profound exploration is conducted functional ferroptosis-related molecules, intracellular pathways, metabolic cascades, signaling transduction routes. Novel ferroptosis inhibitors are introduced detail, covering their design blueprints, synthetic methodologies, bioactivity profiles. Moreover, exhaustive account provided regarding involvement malignancies, neurodegenerative disorders, cardiovascular ailments, other pathologies. By highlighting pivotal status potential regimens various this aspires to furnish thorough reference framework for future investigations clinical translations domain.

Language: Английский

Citations

0
DDR1 Targeting HOXA6 Facilitates Bladder Cancer Progression via Inhibiting Ferroptosis DOI Creative Commons
Xin Xie, Hongchao He, Ning Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(6)

Published: March 1, 2025

ABSTRACT Ferroptosis is an important factor affecting the progression of bladder cancer (BC). Previous studies have confirmed that discoidin domain receptor 1 (DDR1) promotes BC progression. However, regulatory mechanisms ferroptosis are largely unknown. Therefore, this study aimed to investigate effects DDR1 on cell ferroptosis. Ferroptosis‐sensitive and ‐resistant cells were screened, reverse‐transcription quantitative PCR western blotting used determine expression in cells. In vitro vivo assays performed analyse The inducer erastin inhibited TCCSUP inhibitor ferrostatin‐1 death caused by knockdown. increased glutathione, glutathione peroxidase 4 solute carrier family 7 member 11 expression, while decreasing malondialdehyde Fe 2+ levels acyl‐CoA synthetase long‐chain inhibiting epithelial mesenchymal transition neurofibromin 2‐yes‐associated protein. These abrogated knockdown homeobox A6 (HOXA6). targeting HOXA6 facilitated growth vivo. HOXA6. Thus, may serve as a potential therapeutic target for BC.

Language: Английский

Citations

0