Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Research has highlighted numerous detrimental consequences of thiamine deficiency on digestive function. These range from impaired gastric and intestinal motility to aberrant changes in pancreatic exocrine function, acidity disturbances gut barrier integrity inflammation. Thiamine its pharmacological forms, as a primary or adjunctive therapy, have been shown improve symptoms such nausea, constipation, dysphagia dysmotility, both humans animals. This review aims explore molecular mechanisms underlying the therapeutic action gastrointestinal dysfunction. Our analysis demonstrates that insufficiency restricted system, i.e., lacking well-known dry wet beriberi, may arise through (i) disbalance between nutrient influx efflux system due increased demands by organism; (ii) direct exposure oral drugs microbiome, targeting thiamine-dependent metabolism first line; (iii) involvement acetylcholine (ACh) signaling cholinergic activity enteric nervous non-neuronal cells pancreas, employing coenzyme non-coenzyme actions thiamine. The relies requirement form - diphosphate for production energy (ACh). involves participation and/or derivatives, including triphosphate, regulation ACh synaptic consistent with early data co-mediator neuromuscular synapses, allosteric metabolic enzymes. By examining available evidence focus we deepen understanding thiamine's contribution overall health, highlighting important implications functional disorders.

Language: Английский