Time to Conquer Fungal Infectious Diseases: Employing Nanoparticles as Powerful and Versatile Antifungal Nanosystems against a Wide Variety of Fungal Species

Sustainability, Journal Year: 2022, Volume and Issue: 14(19), P. 12942 - 12942

Published: Oct. 10, 2022

The development of novel antifungal agents and, in particular, the widespread use these medications over course past two decades, has had a significant impact on treatment fungal infectious diseases. This resulted complete transformation However, antibiotic resistance masked significance such breakthroughs. Antifungal infection with nanoparticles been shown to be effective. As result their unique characteristics, substances, contrast antibiotics purest form, are able exhibit an increased anti-proliferative capacity while requiring lower concentration than traditional drugs do order achieve same effect. Decreased drug effectiveness, minimal tissue penetration throughout tissue, restricted penetration, decreased bioavailability, poor pharmacokinetics, and low water solubility some major factors contributing employment medicines delivery systems. Because this, one primary goals incorporating into varying sorts is reduce negative effects drugs’ inherent qualities. article provides overview many types nanoparticles, as metal, metal oxide, non-metal oxide carbon-based nanostructured lipid carriers, polymeric solid nanofibers, peptides, composites, ZnO quantum dots, that can used systems, well benefits nanomaterials have purified medications.

Language: Английский

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A call to reconceptualize lichen symbioses

Trends in Ecology & Evolution, Journal Year: 2022, Volume and Issue: 37(7), P. 582 - 589

Published: April 6, 2022

Language: Английский

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Chronic Ionizing Radiation of Plants: An Evolutionary Factor from Direct Damage to Non-Target Effects

Plants, Journal Year: 2023, Volume and Issue: 12(5), P. 1178 - 1178

Published: March 4, 2023

In present times, the levels of ionizing radiation (IR) on surface Earth are relatively low, posing no high challenges for survival contemporary life forms. IR derives from natural sources and naturally occurring radioactive materials (NORM), nuclear industry, medical applications, as a result disasters or tests. current review, we discuss modern radioactivity, its direct indirect effects different plant species, scope protection plants. We an overview molecular mechanisms responses in plants, which leads to tempting conjecture evolutionary role limiting factor land colonization diversification rates. The hypothesis-driven analysis available genomic data suggests overall DNA repair gene families’ depletion plants compared ancestral groups, overlaps with decrease exposure millions years ago. potential contribution chronic combination other environmental factors is discussed.

Language: Английский

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OMICS and Other Advanced Technologies in Mycological Applications

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(6), P. 688 - 688

Published: June 19, 2023

Fungi play many roles in different ecosystems. The precise identification of fungi is important aspects. Historically, they were identified based on morphological characteristics, but technological advancements such as polymerase chain reaction (PCR) and DNA sequencing now enable more accurate taxonomy, higher-level classifications. However, some species, referred to "dark taxa", lack distinct physical features that makes their challenging. High-throughput metagenomics environmental samples provide a solution identifying new lineages fungi. This paper discusses approaches including PCR amplification rDNA, multi-loci phylogenetic analyses, the importance various omics (large-scale molecular) techniques for understanding fungal applications. use proteomics, transcriptomics, metatranscriptomics, metabolomics, interactomics provides comprehensive These advanced technologies are critical expanding knowledge Kingdom Fungi, its impact food safety security, edible mushrooms foodomics, secondary metabolites, mycotoxin-producing fungi, biomedical therapeutic applications, antifungal drugs drug resistance, data novel development. also highlights exploring from extreme environments understudied areas identify dark taxa.

Language: Английский

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Fungi as environmental bioindicators

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 892, P. 164583 - 164583

Published: June 3, 2023

Language: Английский

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