Effects of menopause on temperature regulation DOI Creative Commons
Marie Gombert, Kristine Vesterdorf, Andrea Fuller

et al.

Temperature, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 41

Published: April 23, 2025

Changes in thermoregulation, notably the emergence of hot flashes, occur during menopause transition association with reproductive hormonal changes. Hot flashes constitute most characteristic symptom (prevalence 50-80%), and have a substantial negative effect on quality life. Here, we review endocrine changes associated thermoregulatory system its sensitivity to female sex hormones. We then current knowledge underlying neural mechanisms how systems interact females. consider kisspeptin-neurokinin B-dynorphin (KNDy) neuron complex, which becomes hyperactive when estradiol levels decrease. KNDy neurons project from arcuate nucleus areas within hypothalamic preoptic area, where heat loss are triggered, including cutaneous vasodilation sweating - characteristics flash. describe physiology measurement discuss mixed research findings about thresholds for symptomatic individuals. unique situation that arise sleep, relationships between environment, exercise, body mass index flashes. also surgical (with oophorectomy) cancer therapy, conditions frequent, severe, provide an overview treatments hormone therapy targeted neurokinin B-antagonists, recently developed target mechanism Finally, highlight gaps menopausal thermoregulation suggest future directions research.

Language: Английский

Effects of menopause on temperature regulation DOI Creative Commons
Marie Gombert, Kristine Vesterdorf, Andrea Fuller

et al.

Temperature, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 41

Published: April 23, 2025

Changes in thermoregulation, notably the emergence of hot flashes, occur during menopause transition association with reproductive hormonal changes. Hot flashes constitute most characteristic symptom (prevalence 50-80%), and have a substantial negative effect on quality life. Here, we review endocrine changes associated thermoregulatory system its sensitivity to female sex hormones. We then current knowledge underlying neural mechanisms how systems interact females. consider kisspeptin-neurokinin B-dynorphin (KNDy) neuron complex, which becomes hyperactive when estradiol levels decrease. KNDy neurons project from arcuate nucleus areas within hypothalamic preoptic area, where heat loss are triggered, including cutaneous vasodilation sweating - characteristics flash. describe physiology measurement discuss mixed research findings about thresholds for symptomatic individuals. unique situation that arise sleep, relationships between environment, exercise, body mass index flashes. also surgical (with oophorectomy) cancer therapy, conditions frequent, severe, provide an overview treatments hormone therapy targeted neurokinin B-antagonists, recently developed target mechanism Finally, highlight gaps menopausal thermoregulation suggest future directions research.

Language: Английский

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