Multifaceted interactions between cancer cells and glial cells in brain metastasis DOI Creative Commons

Kojiro Ishibashi,

Eishu Hirata

Cancer Science, Journal Year: 2024, Volume and Issue: 115(9), P. 2871 - 2878

Published: July 11, 2024

Abstract Cancer brain metastasis has a poor prognosis, is commonly observed in clinical practice, and the number of cases increasing as overall cancer survival improves. However, experiments mouse models have shown that itself an inefficient process. One reason for this inefficiency microenvironment, which differs significantly from other organs, making it difficult cells to adapt. The microenvironment consists unique resident cell types such neurons, oligodendrocytes, astrocytes, microglia. Accumulating evidence over past decades suggests interactions between glial can positively or negatively influence development metastasis. Nevertheless, elucidating complex remains challenging, part due limitations existing experimental culture. In review, we first provide overview culture methods then examine recent discoveries regarding metastatic surrounding cells, with special focus on astrocytes Finally, discuss future perspectives understanding multifaceted treatment tumors.

Language: Английский

Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders DOI Creative Commons
Olayemi K. Ijomone, Ukwubile Ileje Inelo, Vivian O. Aneke

et al.

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 6, 2025

Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.

Language: Английский

Citations

3
Multifaceted interactions between cancer cells and glial cells in brain metastasis DOI Creative Commons

Kojiro Ishibashi,

Eishu Hirata

Cancer Science, Journal Year: 2024, Volume and Issue: 115(9), P. 2871 - 2878

Published: July 11, 2024

Abstract Cancer brain metastasis has a poor prognosis, is commonly observed in clinical practice, and the number of cases increasing as overall cancer survival improves. However, experiments mouse models have shown that itself an inefficient process. One reason for this inefficiency microenvironment, which differs significantly from other organs, making it difficult cells to adapt. The microenvironment consists unique resident cell types such neurons, oligodendrocytes, astrocytes, microglia. Accumulating evidence over past decades suggests interactions between glial can positively or negatively influence development metastasis. Nevertheless, elucidating complex remains challenging, part due limitations existing experimental culture. In review, we first provide overview culture methods then examine recent discoveries regarding metastatic surrounding cells, with special focus on astrocytes Finally, discuss future perspectives understanding multifaceted treatment tumors.

Language: Английский

Citations

2