Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113935 - 113935

Published: Jan. 5, 2025

Language: Английский

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Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein

Cancer Science, Journal Year: 2024, Volume and Issue: 115(8), P. 2701 - 2717

Published: June 18, 2024

Abstract The rhizome of Zingiber officinale ( Z. ), commonly known as ginger, has been characterized a potential drug candidate due to its antitumor effects. However, the chemotherapeutic effect ginger on human oral cancer remains poorly understood. In this study, we examined effects an ethanol extract rhizomes (ZOE) and identified components responsible for pharmacological activity. ZOE exerts inhibitory activity in by inducing both autophagy apoptosis simultaneously. Mechanistically, ZOE‐induced are attributed reactive oxygen species (ROS)‐mediated endoplasmic reticulum stress response. Additionally, two active ZOE, 1‐dehydro‐6‐gingerdione 8‐shogaol, which were sufficient stimulate initiation induction enhancing CHOP expression. These results suggest that induce ROS generation, upregulate CHOP, initiate apoptosis, hold promising therapeutics against cancer.

Language: Английский

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Anti-Inflammatory 8-Shogaol Mediates Apoptosis by Inducing Oxidative Stress and Sensitizes Radioresistance in Gastric Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 173 - 173

Published: Dec. 28, 2024

Radiotherapy is a powerful tumor therapeutic strategy for gastric cancer patients. However, radioresistance major obstacle to kill cells. Ginger (

Language: Английский

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