Current Research in Parasitology and Vector-Borne Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 100256 - 100256
Published: March 1, 2025
Many antiparasitic drugs have become obsolete and ineffective in treating parasitic diseases. This ineffectiveness arises from parasite drug resistance, high toxicity, low efficacy. Thus, the discovery of novel agents is urgently needed to control Various strategies are employed discovery, design, development. review highlights paradigm searching for bioactive molecules produced during inter- intraspecific competition among organisms, particularly between microbes parasites, as a strategy de novo discovery. Competitive interactions occur when individuals same or different species coexist overlapping niches compete space resources. These well recognized. Therefore, released these promising targets Compelling data indicate that remain potential source because their diversity. antimicrobial producers nature yet be isolated investigated. body evidence underscores success numerous therapeutic drugs, including penicillin, β-lactams, tetracyclines, which been successfully discovered developed infectious comprehensively covers concepts, with particular focus on agents. approach will pave way identifying alternative eradicate diseases continue threaten human health. Additionally, this discusses current mechanisms action, limitations, existing gaps. discussion emphasizes ongoing need explore drugs.
Language: Английский