Targeting p53-p21 signaling to enhance mesenchymal stem cell regenerative potential

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 352 - 363

Published: April 8, 2025

Language: Английский

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Targeting KRAS-G12C in Lung Cancer: The Emerging Role of PROTACs in Overcoming Resistance

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155954 - 155954

Published: April 1, 2025

Language: Английский

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The Peptide PROTAC Modality: A New Strategy for Drug Discovery

MedComm, Journal Year: 2025, Volume and Issue: 6(4)

Published: March 24, 2025

ABSTRACT In recent years, proteolysis targeting chimera (PROTAC) technology has made significant progress in the field of drug development. Traditional drugs mainly focus on inhibiting or activating specific proteins, while PROTAC provides new ideas for treating various diseases by inducing degradation target proteins. Especially peptide PROTACs, due to their unique structural and functional characteristics, they have become a hot research topic. This review detailed description key components, mechanisms, design principles elaborates applications skin‐related diseases, oncology, other potential therapeutic fields, analyzes advantages challenges, looks forward future development prospects. The not only opens up paths development, but also solving resistance safety issues faced traditional small‐molecule drugs. Compared with PROTACs such as multitargeting, biodegradability, low toxicity, flexibility design. With deepening continuous maturity technology, are expected one important strategies discovery, providing hope treatment more intractable diseases. Peptide ushering era precision medicine.

Language: Английский

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CHIP and aging: a key regulator of proteostasis and cellular senescence

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: May 5, 2025

Language: Английский

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