Cell-Penetrating Cyclic and Disulfide-Rich Peptides Are Privileged Molecular Scaffolds for Intracellular Targeting DOI
Sónia Troeira Henriques, Nicole Lawrence, Meng‐Wei Kan

et al.

Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Peptides that have a head-to-tail cyclic backbone tend to be more stable than linear peptides, as do peptides contain one or cross-linking disulfide bond. Some of these and/or rich been reported penetrate cells. These include from wide range natural sources, including plants, spiders, crabs, and humans. In this review we describe the structures biophysical properties selected set such studied in our laboratories. We further how they can engineered enhance their stability cellular uptake, fine-tune selective cell entry activity toward intracellular therapeutic targets. Examples targets described protein-protein interactions implicated cancer, malarial parasites bacterial addition important advances being made with nature-inspired rapid strides machine learning artificial intelligence seen over recent years promise accelerate use de novo design methods produce are able pass through biological membranes. examples where approaches used macrocyclic peptide-drug conjugates membranes even significant oral bioavailability some cases.

Language: Английский

Cell-Penetrating Cyclic and Disulfide-Rich Peptides Are Privileged Molecular Scaffolds for Intracellular Targeting DOI
Sónia Troeira Henriques, Nicole Lawrence, Meng‐Wei Kan

et al.

Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Peptides that have a head-to-tail cyclic backbone tend to be more stable than linear peptides, as do peptides contain one or cross-linking disulfide bond. Some of these and/or rich been reported penetrate cells. These include from wide range natural sources, including plants, spiders, crabs, and humans. In this review we describe the structures biophysical properties selected set such studied in our laboratories. We further how they can engineered enhance their stability cellular uptake, fine-tune selective cell entry activity toward intracellular therapeutic targets. Examples targets described protein-protein interactions implicated cancer, malarial parasites bacterial addition important advances being made with nature-inspired rapid strides machine learning artificial intelligence seen over recent years promise accelerate use de novo design methods produce are able pass through biological membranes. examples where approaches used macrocyclic peptide-drug conjugates membranes even significant oral bioavailability some cases.

Language: Английский

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