Exacerbation of Chronic Spontaneous Urticaria Following Coronavirus Disease 2019 (COVID-19) Vaccination in Omalizumab-Treated Patients

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2023, Volume and Issue: 11(8), P. 2403 - 2410

Published: May 12, 2023

Language: Английский

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A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID‐19 vaccination: The good, the bad, and the ugly

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(3)

Published: March 1, 2024

Abstract Background and Aims Anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have the potential to alter several biological systems concurrently with remolding immune system, most of which are related immunization, while some others known as adverse effects. This review aims explore effects vaccination on oral microenvironment classifies them good, bad, or ugly, a brief facial diseases following disease 2019 (COVID‐19) vaccination. Methods study was comprehensive conducted through searching articles in Medline, Scopus, Google Scholar databases. Results On one side, “Good” impacts oro‐nasal mucosa explained if mucosal responses followed by SARS‐CoV‐2 enough provide immunity. other possible “Bad” “Ugly” vaccine, manifest orofacial events autoimmune reactivations, respectively, should be noted. Exacerbation pre‐existing conditions such lichen planus, pemphigus vulgaris, bullous pemphigoid, Stevens‐Johnson been reported. Conclusion COVID‐19 could affect different alongside stimulating these referred Nonetheless, treatable, healthcare professionals not prevent patients from taking first available

Language: Английский

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Polyethylene glycol hypersensitivity, patient outcomes in a 7-year retrospective study

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(1), P. 93 - 100.e4

Published: March 30, 2024

Language: Английский

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Comparing the accuracy of ANN with transformer models for sentiment analysis of tweets related to COVID-19 Pfizer vaccines

Chaos Solitons & Fractals, Journal Year: 2024, Volume and Issue: 185, P. 115105 - 115105

Published: June 16, 2024

Language: Английский

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Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273) COVID-19 mRNA vaccines and hypersensitivity reactions

Journal of the National Medical Association, Journal Year: 2022, Volume and Issue: 114(6), P. 601 - 612

Published: Oct. 28, 2022

Language: Английский

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ATAK Complex (Adrenaline, Takotsubo, Anaphylaxis, and Kounis Hypersensitivity-Associated Coronary Syndrome) after COVID-19 Vaccination and Review of the Literature

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 322 - 322

Published: Jan. 31, 2023

Anaphylactic events triggered by mRNA COVID-19 vaccines are neither serious nor frequent. Kounis syndrome is described as the concomitant occurrence of acute coronary and hypersensitivity reactions induced vasospastic mediators after an allergic event. caused very rare. Up to now, only a few cases myocardial infarction vaccine administration have been reported. Takotsubo cardiomyopathy characterized transient wall movement abnormalities left ventricular apex, mid-ventricle, or other distribution, usually intense emotional physical stress. has reported, with delayed onset. A new entity association adrenaline administration, cardiomyopathy, anaphylaxis, was recently described: ATAK complex. Here, we report case that occurred together anaphylactic reaction required use adrenaline. The timing referenced clinical symptoms could not exclude idea occurred. Therefore, can assume patient presented We believe highlighting on this complex will aid application proper diagnostic, preventive therapeutic measures.

Language: Английский

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Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 11

Published: Aug. 24, 2023

Sepsis is a life-threatening clinical condition caused by infection and transposition of pathogens pathogen-associated molecular patterns (PAMPs) into the host bloodstream. During sepsis, activation toll-like receptors (TLRs) on immune cells triggers release pro-inflammatory cytokines overstimulates production vasodilatory mediators such as nitric oxide (NO). These vascular changes lead to widespread inflammation, tissue damage, multiple organ failure, often death. New therapeutic options are urgently needed. To this end, thiostrepton (TST) has emerged candidate for sepsis treatment due its action an antibiotic anti-inflammatory molecule (TLR7-9 inhibitor). Reports in literature suggest that TLR9 inhibition substantially suppresses excessive inflammatory response attenuates sepsis-induced mortality cecal ligation puncture (CLP) murine model sepsis. However, best our knowledge, TST never been directly tested option management possibly low water solubility drug delivery issues. facts prompted us test central hypothesis encapsulated phospholipid sterically stabilized micelles (TST-SSM) could be developed novel Thus, using published method encapsulating hydrophobic TST-SSM, we evaluated vivo efficacy TST-SSM nanomedicine polymicrobial We found increased median survival CLP-induced septic mice from 31 44 hr reducing bacterial burden blood peritoneal lavage. Moreover, plasma levels (interleukin 6 tumor necrosis factor-alpha) NO derivatives were also reduced, whereas renal hepatic function biomarkers creatinine aspartate transferase significantly improved. In conclusion, identified significant potential agent management, primarily properties.

Language: Английский

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The March 2021 Thessaly earthquakes and their impact through the prism of a multi-hazard approach in disaster management

Bulletin of the Geological Society of Greece, Journal Year: 2021, Volume and Issue: 58, P. 1 - 1

Published: July 8, 2021

In early March 2021, when Greece was struggling with the evolving third wave of COVID-19 pandemic highest numbers daily cases and fatalities from its initiation, Thessaly struck by a seismic sequence, which included 3 March, Mw = 6.3 mainshock, strongest 6.1 aftershock following day numerous large aftershocks. The mainshock caused extensive damage to houses infrastructure, while aggravated widespread concern among residents. Based on post-event field surveys in affected area, it is concluded that old unreinforced load-bearing masonry walls northeastern part basin suffered most, recent constructions remained intact. As result, hundreds homeless were need immediate temporary sheltering, immediately mobilized Civil Protection authorities manage emergency situation. This had something unique, made management challenge: implementation earthquake response actions incompatible measures limit further spread SARS-CoV-2 virus community during wave. Many have been adapted unprecedented conditions through prism multi-hazard approach disaster their impact. Among others, more different types shelters used prevent overcrowding, supplies distribution processes modified transmission hands surfaces, places for identification isolation suspected designated regular screening testing local population conducted detection virus. From analysis reported earthquake-affected area pre- post- periods as well results rapid post-disaster period, found viral load villages not increased, despite difficult conditions. It can be suggested adaptation new has worked beneficially reduce those involved staff. For this reason, could considered good practice important lesson learned, applied similar future compound emergencies areas geoenvironmental epidemiological characteristics.

Language: Английский

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Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients

Vaccine, Journal Year: 2023, Volume and Issue: 41(32), P. 4693 - 4699

Published: June 15, 2023

Language: Английский

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Human Identical Sequences, hyaluronan, and hymecromone ─ the new mechanism and management of COVID-19

Molecular Biomedicine, Journal Year: 2022, Volume and Issue: 3(1)

Published: May 20, 2022

Abstract COVID-19 caused by SARS-CoV-2 has created formidable damage to public health and market economy. Currently, variants exacerbated the transmission from person-to-person. Even after a great deal of investigation on COVID-19, is still rampaging globally, emphasizing urgent need reformulate effective prevention treatment strategies. Here, we review latest research progress provide distinct perspectives mechanism management COVID-19. Specially, highlight significance Human Identical Sequences (HIS), hyaluronan, hymecromone (“Three-H”) for understanding intervention Firstly, HIS activate inflammation-related genes influence through NamiRNA-Enhancer network. Accumulation hyaluronan induced HIS-mediated HAS2 upregulation substantial basis clinical manifestations especially in lymphocytopenia pulmonary ground-glass opacity. Secondly, detection plasma can be evaluating progression severity Thirdly, spike glycoprotein may bind further serve as an allergen stimulate allergic reaction, causing sudden adverse effects vaccination or aggravation Finally, antisense oligonucleotides inhibitors synthesis (hymecromone) antiallergic agents could promising therapeutic Collectively, Three-H hold key understand pathogenic create strategies

Language: Английский

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