Green synthesis of neuroprotective spirocyclic chalcone derivatives and their role in protecting against traumatic optic nerve injury

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116933 - 116933

Published: Oct. 1, 2024

Language: Английский

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Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Optic nerve (ON) injury causes blindness in adult mammals as their retinal ganglion cells (RGCs) cannot regenerate axons. However, amphibian RGC axons do not experience the same regenerative failure. Studying regeneration process of ON amphibians holds profound implications for medicine and human health. Using transgenic tadpoles laser micro-optics, we developed a reproducible transection model. Through microscopy, functional testing, TUNEL, EdU assays, RNA-seq, characterized response recovery. Our model suggests no chemoattractant gradient exists early regeneration, with defasciculated sprouting random directions from globe-proximal cut end. Once individual reach appropriate anatomical insertion point brain, tract is reinforced by other regenerating axons, restoring normal morphology. Thus, guidance cues or scaffolding brain-innervating likely support later stages regeneration. After 14 days, regenerated morphologically indistinguishable naïve ON, visual function restored. We found evidence death new formation model, suggesting that only pre-existing RGCs are involved

Language: Английский

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Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 9, 2024

Optic nerve (ON) injury causes blindness in adult mammals as their retinal ganglion cells (RGCs) cannot regenerate axons. However, amphibian RGC axons do not experience the same regenerative failure. Studying regeneration process of ON amphibians holds profound implications for medicine and human health. Using transgenic tadpoles laser micro-optics, we developed a reproducible transection model. Through microscopy axon dynamics, functional testing to assess visual pathway recovery, TUNEL cell death EdU proliferation assays, RNA-seq retina optic nerve, characterized response subsequent recovery. Our model suggests no chemoattractant gradient exists early regeneration, with defasciculated sprouting random directions from globe-proximal cut end. Once individual reach appropriate targets brain, tract is reinforced by other regenerating axons, restoring normal morphology. Thus, guidance cues or scaffolding brain-innervating likely support later stages regeneration. After 14 days, regenerated morphologically indistinguishable naïve ON, function restored. We found evidence new formation model, suggesting that involves remodeling injured pre-existing RGCs.

Language: Английский

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From Inner Balance to Visual Health: Unraveling the Therapeutic Role of Yoga in Optic Neuropathy and Ocular Manifestations – Narrative Review

International Journal of Yoga, Journal Year: 2023, Volume and Issue: 16(3), P. 171 - 179

Published: Sept. 1, 2023

Abstract The optic nerve comprises approximately 1.2 million axons of retinal ganglion cells and is vulnerable to degeneration due a myriad causes. While traditional treatments have been the cornerstone ocular care, emerging evidence highlights benefits integrative approaches, which can be used as an adjunct in management neuropathy. Yoga mind–body energy medicine encompasses physical postures, breath control, meditation. Currently, it has gained attention for its holistic effects on well-being, by promoting health, preventing onset diseases, disease management, rehabilitative potential. In addition, underlying mechanisms through yoga exerts therapeutic influence, evaluates clinical outcomes, explores potential synergistic with conventional remain largely unexplored. Neuroprotective yoga, such enhancing cell function, reducing oxidative stress, coupled ability modulate inflammatory processes improve circulation, contribute visual health. Analysis studies reveals promising including improvements acuity, fields, quality life, functional outcomes individuals neuropathy manifestations who undergo intervention (especially dhyaan) awareness breath. Furthermore, integration complementary modalities unveils possibilities multidisciplinary approaches care that need evaluation. By unraveling role this review provides valuable insights clinicians researchers, fostering deeper understanding connection paving way enhanced health outcomes. Embracing adjunctive therapy may revolutionize manifestations, offering approach optimize reduce comorbid depression caregiver burden, overall life.

Language: Английский

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Neuronal regeneration in the mammalian central nervous system

Clinical and Experimental Ophthalmology, Journal Year: 2023, Volume and Issue: 51(6), P. 514 - 515

Published: Aug. 1, 2023

The authors declare no conflict of interest.

Language: Английский

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