Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 29
Published: Nov. 7, 2023
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270
Published: Feb. 12, 2025
The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.
Language: Английский
Citations
4
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116420 - 116420
Published: March 11, 2024
Gut microbiome alterations are associated with various cancers including brain tumours such as glioma and glioblastoma. The gut communicates the via a bidirectional pathway known gut-brain axis (GBA) which is essential for maintaining homeostasis. microbiota produces many metabolites short chain fatty acids (SCFAs) amino glutamate, glutamine, arginine tryptophan. Through modulation of these able to regulate several functions cells, immune cells tumour DNA methylation, mitochondrial function, aryl hydrocarbon receptor (AhR), T-cell proliferation, autophagy even apoptosis. Here, we summarise current findings on respect cancers, an area research that widely overlooked. Several studies investigated relationship between tumours. However, it remains unclear whether variation cause or product cancer. Subsequently, biomarker panel was constructed use predictive, prognostic diagnostic tool multiple glioblastoma multiforme (GBM). This review further presents intratumoural microbiome, fascinating microenvironment within possible treatment target can be manipulated maximise effectiveness personalised therapy. Studies utilising therapeutic strategy necessary accurately assess clinical cancers.
Language: Английский
Citations
14
Acta Neuropathologica Communications, Journal Year: 2024, Volume and Issue: 12(1)
Published: Jan. 19, 2024
Abstract Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility CSF biomarkers. While some show cell-free DNA analysis, analyzing metabolites are limited. Diffuse gliomas have altered cellular metabolism. For example, mutations isocitrate dehydrogenase enzymes (e.g., IDH1 and IDH2 ) common diffuse lead increased levels D-2-hydroxyglutarate CSF. However, there poor understanding changes GBM patients. In this study, we performed targeted metabolomic from n = 31 13 individuals non-neoplastic conditions (controls), by mass spectrometry. Hierarchical clustering sparse partial least square-discriminant (sPLS-DA) revealed differences between control CSF, including associated fatty acid oxidation gut microbiome (i.e., carnitine, 2-methylbutyrylcarnitine, shikimate, aminobutanal, uridine, N-acetylputrescine, farnesyl diphosphate). addition, identified based on presence/absence TP53 or PTEN mutations, consistent idea that different effects tumor summary, our results increase highlight several could be informative biomarkers GBM.
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 991 - 991
Published: Jan. 24, 2025
Brain tumors are frequently diagnosed diseases in which etiology and progression largely depend on mutations genetic factors. Additionally, recent reports document that the microbiome may influence tumor growth, microenvironment, response to therapy. Our goal was examine extent bacterial composition—microbiota—and fungal composition—mycobiota—characteristic of its microenvironment correlate with composition gut blood microbiota mycobiota five randomly selected brain patients. The tumor, tumor-adjacent tissue (TAT), blood, samples patients were analyzed by 16S rRNA ITS-based sequencing order determine composition. mycobiome showed individual tissue-specific signatures each patient. TAT, very similar patient, dominated Klebsiella, Enterococcus, Blautia, Lactobacillus spp. In contrast, a diverse, picture. most common species TAT Tomentella, Didymosphaeria, Alternaria, Penicillium, Mycosphaerella, Discosia. other but unique characteristic tissues, Malassezia, Schizophyllum, Tomentella genus fungi genus. results presence shows pattern is independent observed gut, environment effects distinct cannot be associated those microbiome. Elucidating role exploring relationship between types open up further therapeutic options.
Language: Английский
Citations
1
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(S1), P. 84 - 97
Published: Jan. 10, 2023
In recent decades, various roles of the gut microbiota in physiological and pathological conditions have been uncovered. Among many interacting pathways between host flora, gut-brain axis has drawn increasing attention is generally considered a promising way to understand treat brain tumors, one most lethal neoplasms. this narrative review, we aimed unveil dissect sophisticated mechanisms by which exerts its influence on tumors. Furthermore, summarized latest research regarding gastrointestinal microbial landscape effect malfunction different Finally, outlined ongoing developing approaches manipulation their corresponding related neuro-malignancies. Collectively, recapitulated advances alterations along with potential interactive tumors encouraged increased efforts area.
Language: Английский
Citations
19
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Aug. 26, 2024
Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has revealed critical role of gut microbiota influencing health disease, indicating its possible impact on glioma pathogenesis treatment responsiveness. This review focused existing evidence hypotheses relationship between from progression invasion. By discussing mechanisms through which may affect biology, this paper offers new avenues for targeted therapies precision medicine oncology.
Language: Английский
Citations
6
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 6, 2025
Background Recent research on the gut-brain axis has deepened our understanding of correlation between gut bacteria and neurological system. The inflammatory response triggered by microbiota may be associated with neurodegenerative diseases. Additionally, impact emotional state, known as “Gut-mood” relationship, could play a role in depression anxiety disorders. Results This review summarizes recent data pathophysiology neuropsychiatric disorders including epilepsy, schizophrenia, Alzheimer’s disease, brain cancer, Parkinson’s bipolar disorder stroke. Also, we conducted Mendelian randomization study seven (Epilepsy, stroke). MR-Egger MR-PRESSO tests confirmed robustness analysis against horizontal pleiotropy. Conclusions By comparing protective risk factors for found other researches, can furtherly determine valuable indicators disease evolution tracking potential treatment targets. Future should explore extensive microbiome genome-wide association datasets using metagenomics sequencing techniques to deepen connections causality
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 28, 2025
Language: Английский
Citations
0
Exploration, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
ABSTRACT The concept of the microbiota‐gut‐brain axis has witnessed significant advancements, and observational studies revealed dysbiosis in gut microbiota patients with brain tumors. causal relationship between tumors potential prognostic value are still unclear. Based on multiple Mendelian randomization analyses, this study confirms effects four microbes meningioma, seven pituitary tumor, eight glioma. Sherlock framework, identifies 103 meningioma‐related microbe‐related genes (MRGs), 40 tumor‐related MRGs, 63 glioma‐related MRGs expressed tissues. Almost all associated tumor grade prognosis. Lastly, model based machine learning established study, namely signature (MRS), could robustly predict prognosis glioma provide insights for immunotherapy benefits. This presents evidence tumors, which contributes to our understanding axis. prognosis, along prediction capacity MRS its association immunotherapy, provides support use as biomarkers evaluate treatment response
Language: Английский
Citations
0
Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100131 - 100131
Published: May 1, 2025
Language: Английский
Citations
0