Striatal dopamine depletion drives disease progression and network topology aberrations specifically by impairing left primary motor cortex network DOI Creative Commons
Jun Liu, Zhichun Chen, Guanglu Li

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract The understanding of pathophysiological mechanisms underlying symptom severity and brain network aberrations in Parkinson’s disease (PD) can offer objective, theoretically supported targets to develop novel interventions prevent the onset progression motor non-motor symptoms. objective current study is explore how stratal dopamine depletion, a pathogenic driver PD, shapes networks. PD participants (n = 141) undergoing functional magnetic resonance imaging from Progression Markers Initiative (PPMI) database were investigated. Based on quartiles striatal binding ratio (SBR) striatum, patients divided into Q1 group (SBR level rank: 0%~25%), Q2-3 25%~75%), Q4 75%~100%). associations between depletion clinical manifestations or networks characterized by integrative analysis, multiple linear regression mediation analysis. exhibited worsening symptoms compared group. Additionally, both structural topology significantly differ Specifically, connectivity left primary cortex (M1) was much lower group, which mediated topological disruptions network. Importantly, impaired M1 subnetwork aberrant effects These data demonstrate that specifically impairs disturb precipitate symptoms, supporting realistic neuromodulation target for PD.

Language: Английский

Striatal Dopamine Depletion Drives Disease Progression and Network Topology Aberrations Specifically by Impairing Left M1 Network DOI
Zhichun Chen, Guanglu Li, Liche Zhou

et al.

Published: Jan. 1, 2023

Background: Stratal dopamine depletion contributes to both motor and non-motor symptoms of patients with Parkinson’s disease (PD). The objective current study is explore whether stratal shapes clinical heterogeneity by impairing brain networks PD patients.Methods: In this cross-sectional study, participants undergoing functional magnetic resonance imaging from Progression Markers Initiative (PPMI) database were investigated. According the levels striatal binding rations (SBR) in bilateral striatum, classified into lower quartile group (SBR level rank: 0%~25%), interquartile 26%~75%), upper 76%~100%) based on their SBR quartiles examine how affects manifestations networks.Findings: showed more severe compared group. Additionally, topological metrics structural network significantly different between Furthermore, left primary cortex (M1) was specifically impaired group, which resulted disruptions network. Importantly, M1 mediated effects symptoms.Interpretation: Striatal network, contributed aberrant topology dopamine-dependent symptoms.Funding: National Natural Science Foundation China (Grant No. 81873778, 82071415) Research Center for Translational Medicine at Shanghai NRCTM(SH)-2021-03).Declaration Interest: authors have no conflict interest report.Ethical Approval: Institutional Review Committee all participating sites approved PPMI study. informed consents been signed participants.

Language: Английский

Citations

0
Structural network topology mediated cognitive impairment in Parkinson’s disease DOI Open Access
Zhichun Chen, Guanglu Li, Liche Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 25, 2023

Abstract Cognitive impairment (CI) is one of the most prominent non-motor symptoms in Parkinson’s disease (PD). How brain network abnormalities contribute to CI PD patients remain largely unclear. The goal this study explore whether aberrations topology were causally associated with cognitive decline patients. receiving magnetic resonance imaging from Progression Markers Initiative (PPMI) database specifically selected. According scores Montreal Assessment (MoCA), classified into CI+ group (MoCA score ≤ 25) and CI-group > investigate clinical features networks significantly different between two groups. Mediation analysis was utilized evaluate alterations contributed We revealed + exhibited more severe compared CI-group. In addition, age, excessive daytime sleepiness, depressive found be Moreover, statistically local topological properties structural Furthermore, differential metrics meditated effects depression on Taken together, out suggested that notable disturbances topology, which mediated negative associations

Language: Английский

Citations

0
High-level anxiety is associated with worse clinical symptoms and aberrant brain networks in Parkinson’s disease DOI Open Access
Zhichun Chen, Guanglu Li, Liche Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 26, 2023

Abstract Background Anxiety is one of the most common psychiatric symptoms in Parkinson’s disease (PD). Whether anxiety shapes progression and brain network aberrations PD remain largely unknown. The objective present study to investigate whether exacerbates clinical abnormalities patients. Methods patients performing magnetic resonance imaging from Progression Markers Initiative (PPMI) database were specifically included. According scores State-Trait Inventory (STAI), classified into lower quartile group (STAI score rank: 0%∼25%), interquartile 26%∼75%), upper 76%∼100%) based on their STAI quartiles how affects manifestations networks. Results was independently associated with both motor non-motor Consistently, showed more severe compared group. Moreover, they also exhibited significantly different topological metrics structural Furthermore, we demonstrated that differential mediated associations between Conclusions higher level disruptions topology. Diverse

Language: Английский

Citations

0
Striatal dopamine depletion drives disease progression and network topology aberrations specifically by impairing left primary motor cortex network DOI Creative Commons
Jun Liu, Zhichun Chen, Guanglu Li

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract The understanding of pathophysiological mechanisms underlying symptom severity and brain network aberrations in Parkinson’s disease (PD) can offer objective, theoretically supported targets to develop novel interventions prevent the onset progression motor non-motor symptoms. objective current study is explore how stratal dopamine depletion, a pathogenic driver PD, shapes networks. PD participants (n = 141) undergoing functional magnetic resonance imaging from Progression Markers Initiative (PPMI) database were investigated. Based on quartiles striatal binding ratio (SBR) striatum, patients divided into Q1 group (SBR level rank: 0%~25%), Q2-3 25%~75%), Q4 75%~100%). associations between depletion clinical manifestations or networks characterized by integrative analysis, multiple linear regression mediation analysis. exhibited worsening symptoms compared group. Additionally, both structural topology significantly differ Specifically, connectivity left primary cortex (M1) was much lower group, which mediated topological disruptions network. Importantly, impaired M1 subnetwork aberrant effects These data demonstrate that specifically impairs disturb precipitate symptoms, supporting realistic neuromodulation target for PD.

Language: Английский

Citations

0