Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas DOI
Can Peng, Wei Chen, Jun Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Abstract Histone methyltransferase EZH2, primarily localized in the nucleus, mediates constitutive Polycomb repressive complex activity by trimethylating lysine 27 of histone H3 (H3K27me3), leading to gene silencing through canonical and noncanonical mechanisms, resulting transcriptional repression or activation. Its involvement is crucial cell growth, proliferation, differentiation, apoptosis, with its effects linked regulation various targets signaling pathways. Overexpression EZH2 alters expression function, thereby facilitating cancer progression. Recent research has identified potential prognostic role glioma patients. This study assesses clinicopathological significance value gliomas using available data. The mRNA levels tumor tissues normal were assessed timer2.0 data from CGCA TGCA. was determined Kaplan-Meier plotter. A total 147 clinical samples patients underwent immunohistochemistry analysis evaluate protein expression. Cox proportional hazards regression model survival curves employed assess relationship between expression, parameters, overall (OS). Across multiple cohorts, found be upregulated amplified tissues. In high-grade patients, significantly increased, higher correlated poorer OS, disease-specific (DSS), progression-free interval (PFI). Therefore, level may serve as a biomarker for

Language: Английский

Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9 DOI Creative Commons
Qingyu Zhao, Yong Li,

Qian Sun

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101606 - 101606

Published: Feb. 27, 2025

Language: Английский

Citations

2
Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies DOI

Xiaoyu Luan,

Peng Chen, Longyu Miao

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 31, 2024

Language: Английский

Citations

11
Unveiling the potential of ursolic acid modified hyaluronate nanoparticles for combination drug therapy in triple negative breast cancer DOI
Reena Sharma, Vivek R. Yadav, Shikha Jha

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 338, P. 122196 - 122196

Published: April 24, 2024

Language: Английский

Citations

11
Self‐Assembled nanoparticles of natural bioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma DOI Creative Commons

Yong Li,

Qingyu Zhao, Xinyi Zhu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)

Published: Dec. 4, 2023

Abstract Background Glioblastoma (GBM) is the most common primary malignant tumor in central nervous system. Paclitaxel (PTX) a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, application of PTX GBM hindered by several limitations, including poor water solubility, restricted entry across blood–brain barrier (BBB), enhanced excretion efflux transporters. P‐glycoprotein (P‐gp) crucial transporter that abundantly present cerebral vascular endothelial cells cells. It plays significant role exocytosis within tissues. Methods Recently, we have developed novel technique creating self‐assembled nanoparticles utilizing range natural bioactive molecules. These can encapsulate insoluble drugs effectively cross BBB. In additional, revealed certain potential to act as P‐gp inhibitors, thereby reducing PTX. this study, conducted screening molecular identify those inhibit function Results Among candidates, identified ursolic acid (UA NPs) inhibitors. Furthermore, prepared co‐assembled UA NPs embedded with paclitaxel, referred UA‐PTX NPs. Our results demonstrate enhance blood concentration PTX, facilitate its into BBB, P‐gp, resulting decrease This discovery addressed above three issues associated use glioma treatment. Conclusions strong anti‐tumor effects show great treating GBM.

Language: Английский

Citations

16
Preoperative geriatric nutritional risk index is useful factor for predicting postoperative delirium among elderly patients with degenerative lumbar diseases DOI
Qian Chen, Ce Zhu, Youwei Ai

et al.

European Spine Journal, Journal Year: 2024, Volume and Issue: 33(3), P. 1055 - 1060

Published: Feb. 11, 2024

Language: Английский

Citations

4
Phytocompounds and Nanoformulations for Anticancer Therapy: A Review DOI Creative Commons
Giuseppina Bozzuto, Annarica Calcabrini, Marisa Colone

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3784 - 3784

Published: Aug. 9, 2024

Cancer is a complex disease that affects millions of people and remains major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, radiotherapy, have limited achievements multiple drawbacks, among which are healthy tissue damage multidrug-resistant phenotype onset. Increasing evidence shows many plants’ natural products, as well their bioactive compounds, promising anticancer activity exhibit minimal toxicity compared to conventional drugs. However, widespread use in therapy severely restricted by limitations terms water solubility, absorption, lack stability, bioavailability, selective targeting. The nanoformulations for product transportation delivery could be helpful overcoming these limitations, thus enhancing therapeutic efficacy providing the basis improved treatment strategies. present review aimed at an update on some phytocompounds (curcumin, resveratrol, quercetin, cannabinoids, others) main showing antitumor activities, both vitro vivo, against such different human types breast colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, osteosarcoma. intracellular pathways underlying phytocompound advantages nanoformulation employment also examined. Finally, this critically analyzes research gaps causing success phytocompounds’ nanoformulations’ clinical translation.

Language: Английский

Citations

4
RNA-Seq transcriptomic landscape profiling of spontaneously hypertensive rats in youth treated with a ARNI versus ARB DOI

Jian Ma,

Xumin Xin,

Yuewang Jia

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

0
Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Ursolic Acid for Breast Cancer Therapy DOI Creative Commons

Pattaree Payomhom,

Nattawadee Panyain, Chadamas Sakonsinsiri

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 5383 - 5395

Published: Feb. 28, 2024

Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and herbs, has the potential as an anticancer agent against multiple cancer types. Nevertheless, its clinical use was limited by poor water solubility. To overcome this drawback, several nanocarriers were proposed to increase bioavailability efficacy of UA. However, insights into cellular targets mechanisms UA nanoparticles (NPs) remain limited. In study, chitosan-coated poly(lactic-co-glycolic acid) (PLGA/CS) NPs loaded with The obtained (UA)-PLGA/CS spherical approximate size 250 nm encapsulation efficiency 25%. Owing their promising drug carriers, successfully delivered breast cells (MCF-7 MDA-MB-231). Moreover, enhanced activity UA, evidenced IC50 values 26.74 40.67 μM MCF-7 MDA-MB-231 cells, respectively. These lower than those free (90.25 85.63 respectively). improved cytotoxicity induced can be attributed apoptosis induction, collective cell migration invasion inhibition, proliferation pathway disruption. findings led better understanding effects molecular for therapy.

Language: Английский

Citations

3
Anti‐Inflammatory Treatment of Subarachnoid Hemorrhage by Self‐Assembled Silymarin Nanoparticles DOI Creative Commons

Yong Li,

Youdong Zhou,

Yinqiu Tan

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and mortality. Early brain injury (EBI) the main cause of mortality delayed neurological dysfunction in patients SAH. Neuroinflammation important pathological processes EBI.We prepared Silymarin nanoparticles (SIM NPs) through solvent precipitation method investigated their role combating EBI following SAH mice. We found that SIM NPs diameter 150 nm have strongest ability to cross blood‐brain barrier. are spherical contain irregular particles inside, which may be composed mainly silibinin assembled hydrogen bonding. Further vivo experiments showed improved short‐term mice, reduced cortical neural damage, inflammation Nrf2/STING pathway. Finally, water maze can improve long‐term memory learning Based on above results, we conclude silymarin reduce after by inhibiting pathway, neuroinflammation M1 polarization microglia.

Language: Английский

Citations

0
A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy DOI Creative Commons
Jing Lin,

Wenguang Xiao,

Zhenlin Hu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 5779 - 5797

Published: May 1, 2025

Language: Английский

Citations

0