Evaluating the effects of tDCS on depressive and anxiety symptoms from a transdiagnostic perspective: a systematic review and meta-analysis of randomized controlled trials

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 18, 2024

Abstract Depressive and anxiety symptoms are prevalent among patients with various clinical conditions, resulting in diminished emotional well-being impaired daily functioning. The neural mechanisms underlying these symptoms, particularly across different disorders, remain unclear, limiting the effectiveness of conventional treatments. Therefore, it is crucial to elucidate underpinnings depressive investigate novel, effective treatments conditions. Transcranial direct current stimulation (tDCS) a neuromodulatory technique that can help understand facilitate development interventions, addressing two research gaps at both levels. Thus, this systematic review meta-analysis aims evaluate existing evidence regarding therapeutic efficacy tDCS reducing individuals diverse diagnoses. This evaluated from fifty-six randomized, sham-controlled trials administered repeated sessions parallel design, applying three-level meta-analytic model. targeting left dorsolateral prefrontal cortex (DLPFC) 2-mA intensity demonstrates moderate alleviating identifying DLPFC as transdiagnostic mechanism In comparison, findings on demonstrate greater heterogeneity. over shows promising effects These enhance our understanding neuropsychological basis laying groundwork for more interventions applicable

Language: Английский

---

Dual‐tDCS combined with sensorimotor training promotes upper limb function in subacute stroke patients: A randomized, double‐blinded, sham‐controlled study

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)

Published: Nov. 23, 2023

Abstract Background Dual transcranial direct current stimulation (tDCS) over the bilateral primary somatosensory cortex (PSC) has potential benefits in stroke. In addition, compared with traditional rehabilitation training, sensorimotor training can significantly improve function of patients. However, efficacy dual‐tDCS combined patients subacute stroke is unknown. Objective To assess whether may enhance on upper limb functions this study aims to explore clinical mechanism combination therapy. Methods We randomized 52 individuals first‐ever, unilateral subcortical into experimental group ( n = 26) and control 26). Patients received 20 min PSC 40 each session, while sham dual‐tDCS. The treatment cycle was a 1‐h session therapy day, 5 days per week for 4 weeks. Fugl–Meyer Assessment Upper Extremity (FMA–UE) subscale, Action Research Arm Test (ARAT), Box Block test (BBT), Erasmus MC revised Nottingham sensory assessment scale (Em‐NSA), Neurometer nerve quantitative detector (CPT), Barthel index (BI), Hospital Anxiety Depression Scale (HADS) were used function, activities daily living (ADL), mental health before after 4‐week period. functional near‐infrared spectroscopy (fNIRS) brain mechanisms. Results Both groups showed significant improvement all scales (All p < 0.05) treatment. Compared sham‐tDCS plus active coupled FMA‐UE, ARAT, Em‐NSA‐Stereognosis, CPT‐2K Hz. activate left pre‐Motor supplementary motor (PM–SMC) connection between association (SAC) RPM–SMC. Furthermore, difference FMA–UE positively correlated connectivity RPM‐SMC‐LSAC r 0.815, 0.001). Conclusion Dual‐tDCS dysfunction, ADL, alleviate depression anxiety Our results indicated that be therapeutic targets

Language: Английский

---

Local effective connectivity changes after transcranial direct current stimulation in obsessive-compulsive disorder patients

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 116 - 127

Published: Jan. 11, 2025

This study investigates the effects of transcranial direct current stimulation (tDCS) on brain network connectivity in individuals with obsessive-compulsive disorder (OCD). In a randomized, double-blind, sham-controlled experimental design anodal tDCS (vs. sham) was applied total 43 right-handed patients OCD, targeting right pre-supplementary motor area (pre-SMA). Cathodal reference electrode put left pre-SMA. The set as 2 mA, duration either 30 s (sham) or 1200 s. Concurrent resting-state functional MRI data were collected following (or stimulation. We employed regression dynamic causal modelling (rDCM) to extract whole effective (EC) matrices subsequently analyzing these through graph theory approaches examine changes activity across different scales. found that compared sham caused significant local connectivity. Increased recruitment level detectable sensorimotor (SMN), indicating enhanced intra-network after active tDCS. Clustering coefficient and efficiency also be increased same area. No regard global Current findings indicate single-session can effectively alter connectivities within SMN OCD patients. Given relevance connected regions for pathophysiology we believe areas might constitute an intervention normalize altered OCD. used single session, which may not reflect long-term effects.

Language: Английский

---

Effects of occupational therapy synchronized with dual transcranial direct current stimulation on upper limb function and electroencephalography power in subacute stroke patients: A randomized, double-blind, controlled study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320142 - e0320142

Published: March 18, 2025

Background Occupational therapy (OT) and transcranial direct current stimulation (tDCS) are both important methods for promoting the recovery after stroke. There limited researches that simultaneously apply investigate their effects on upper limb function. Objective To of OT synchronized with dual tDCS motor function Electroencephalogram (EEG) power in subacute stroke patients. Methods Forty-five patients were randomly assigned to control group (n = 23) experimental 22), receiving sham real concurrent respectively, five times a week, duration two weeks. Upper cortical EEG evaluated by Fugl-Meyer Assessment Extremity (FMA-UE), Modified Barthel Index (MBI) Action Research Arm Test (ARAT), Delta/Alpha Ratio (DAR) pairwise derived Brain Symmetry (pdBSI) at baseline Results Finally, total 39 completed study included analysis. The results revealed participants showed significant better evolution FMA-UE (p < 0.001), MBI 0.034), DAR primary cortex (M1) area 0.022) pdBSI 0.025) compared group. Conclusions In patients, central-peripheral combined approach, which involves (central stimulation) synchronous (peripheral sensory-motor enhanced alone, leading greater improvements normalization brain activity. Trial registration This trial was registered Chinese Clinical Registry (No. ChiCTR2400082749).

Language: Английский

---

Transcranial direct current stimulation for upper and lower limb motor dysfunction after stroke: a systematic review and meta-analysis of randomized controlled trials

Brain Network and Modulation, Journal Year: 2025, Volume and Issue: 4(1), P. 1 - 12

Published: Jan. 1, 2025

Transcranial direct current stimulation (tDCS) has emerged as a promising noninvasive intervention for motor recovery after stroke, yet its therapeutic efficacy remains unclear. This study was designed to systematically evaluate the effectiveness of tDCS upper and lower extremity function in stroke patients. A comprehensive search conducted randomized controlled trials published before February 6, 2025, across five databases: PubMed, Embase, Web Science, Cochrane Library, Scopus. The Fugl-Meyer Assessment Scales Upper Lower Extremities served primary evaluation metrics, complemented by secondary measures, including Action Research Arm Test, Timed Up Go Barthel Index. Two independent investigators screened literature, Risk Bias Tool employed assess quality extract relevant data. total 24 were included analysis. Meta-analysis outcomes revealed that had positive effect on improving limb (mean difference ( MD ) = 1.628, 95% confidence interval CI ): 1.145-2.111, P < 0.001) but not improvement 1.133, : –0.031–2.298, 0.056). Subgroup analyses optimal parameters: anodal M1 region 1.707, 1.159–2.256), intensity ≥ 0.05 mA/cm 2 1.652, 0.862–2.442), treatment duration exceeding weeks 1.848, 0.703–2.994). Notably, benefits particularly evident during acute subacute rehabilitation phases. Current evidence suggests demonstrates clinically meaningful enhancement patients, whereas functional inconclusive.

Language: Английский

---

Unveiling Cognitive Interference: fNIRS Insights Into Poststroke Aphasia During Stroop Tasks

Neural Plasticity, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This study examined blood oxygenation changes during a modified Stroop task with colored Chinese words using functional near‐infrared spectroscopy (fNIRS) in patients poststroke aphasia. The included three conditions: neutral, congruent, and incongruent. Participants consisted of 15 healthy adults Compared to adults, aphasic showed significantly longer reaction times reduced accuracy across all conditions, more pronounced interference effect the incongruent condition. fNIRS analysis revealed distinct neurophysiological differences: decreased activation Broca’s area, increased ventromedial frontal pole, atypical recruitment left dorsolateral prefrontal cortex (DLPFC) tasks. These findings highlight differing neural mechanisms underlying cognitive integration enhances our understanding intentional inhibition deficits impact patients. Importantly, these results suggest that control abnormalities regions, such as pole DLPFC, may be potential targets for noninvasive neuromodulation improve observed patterns regions underscore their critical role managing inhibition. Noninvasive brain modulation techniques offer promising strategies modulating mechanisms. underscores need targeted interventions address dysfunctions emphasizes value visual language tasks exploring complex relationship between this population.

Language: Английский

---

Efficacy of kinesthetic motor imagery based brain computer interface combined with tDCS on upper limb function in subacute stroke

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 7, 2025

This study investigates whether the combined effect of kinesthetic motor imagery-based brain computer interface (KI-BCI) and transcranial direct current stimulation (tDCS) on upper limb function in subacute stroke patients is more effective than using KI-BCI or tDCS alone. Forty-eight survivors were randomized to KI-BCI, tDCS, BCI-tDCS group. The group performed 30 min training. Patients received tDCS. 15 KI-BCI. treatment cycle was five times a week, for four weeks. After all intervention, Fugl-Meyer Assessment-Upper Extremity, Motor Status Scale, Modified Barthel Index scores superior those terms Scale. Although quantitative EEG showed no significant differences, indices significantly lower before treatment. In conclusion, after treatment, although intervention strategies improved daily living abilities patients, demonstrated better efficacy Under same total duration, use did not achieve hypothesized optimal outcome. Notably, reduced QEEG indices, possibly indicating favorable future outcomes future.Trial registry number: ChiCTR2000034730.

Language: Английский

---

Association of hemoglobin drift and outcomes in patients with aneurysmal subarachnoid hemorrhage

Neurosurgical Review, Journal Year: 2024, Volume and Issue: 47(1)

Published: July 10, 2024

Language: Английский

---

The Impact of Bilateral Cerebellar Transcranial Direct Current Stimulation on Balance Control in Healthy Young Adults

The Cerebellum, Journal Year: 2024, Volume and Issue: 23(6), P. 2468 - 2476

Published: Oct. 9, 2024

Language: Английский

---

Editorial: Neuromuscular adaptations to sensorimotor stimulation protocols: potential rehabilitative interventions for individuals with central or peripheral neuromuscular injuries

Frontiers in Rehabilitation Sciences, Journal Year: 2024, Volume and Issue: 5

Published: March 6, 2024

EDITORIAL article Front. Rehabil. Sci., 06 March 2024Sec. Rehabilitation for Musculoskeletal Conditions Volume 5 - 2024 | https://doi.org/10.3389/fresc.2024.1388989

Language: Английский

---