tDCS combined with kinesthetic motor imagery-based brain computer interface training promotes upper limb function in subacute stroke: A randomized controlled study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Background Most stroke survivors have upper extremity dysfunction. According to neuroplasticity theory, transcranial direct current stimulation (tDCS) and kinesthetic motor imagery-based brain computer interface (KI-BCI) the potential improve function of participants with subacute stroke. However, efficacy tDCS combined KI-BCI in is unknown. Objective To investigate whether effect on limb more effective than effects or alone. Methods We randomized 48 into a group (n = 16), tDCS-BCI 16). Participants received 30 min anode over M1. The performed training. 15 KI-BCI. All conventional intervention. treatment cycle consisted 1 session each day, 5 days per week for 4 weeks. Fugl–Meyer Assessment Upper Extremity (FMA-UE) subscale, Motor Status Scale (MSS), Action Research Arm Test (ARAT), Modified Barthel Index (MBI) were used assess function, activities daily living (ADL) before after 4-week period. In addition, electroencephalography (EEG) was explore clinical mechanisms. Results After four weeks intervention, superior terms MSS. FMA-UE, MSS, MBI scores those group. There no difference number quantitative EEGs among three groups, while greater before. Conclusion TDCS KI-CI training can function. alone ADL simultaneously. could alter electrical excitatory levels cerebral hemispheres. Trial registry number: ChiCTR2000034730

Language: Английский

Differences in brain activation and connectivity during unaffected hand exercise in subacute and convalescent stroke patients

Neuroscience, Journal Year: 2024, Volume and Issue: 565, P. 10 - 18

Published: Nov. 17, 2024

Patients experiencing severe hemiplegia following a stroke struggle to rehabilitate their affected limbs. Cross-education (CE) training emerges as promising rehabilitation method due its safety, simplicity, low risk, and ability effectively improve muscle strength in the limb. However, controversy surrounds neural mechanisms clinical applications of CE. To address this, we employed functional near-infrared spectroscopy monitor response regions interest (ROI) connectivity patients with during one session 50% maximal voluntary contraction (MVC) less-affected hand both subacute convalescent phases. Our objective was compare two groups gain insight into potential utility for unilateral limb an effective approach different phases post stroke. The findings revealed varying degrees activation ROIs within hemisphere across task. Additionally, found that (SPS) had higher blood oxygen levels ipsilesional primary motor (iM1), pre-motor supplementary area (iP-SMA) contralesional P-SMA (cP-SMA). Functional between iM1 brain regions, well iP-SMA ROIs, showed statistically significant differences SPS compared (CPS) MVC using hand. SIGNIFICANCE STATEMENT: Exploring underlying sheds light on safe therapy. study enhances our understanding investigates feasibility future approach. Analyzing how affects could lead more tailored strategies.

Language: Английский