Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 203 - 213
Published: Nov. 29, 2024
Language: Английский
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(14), P. 2545 - 2564
Published: July 9, 2024
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative and remains formidable global health challenge. The current medication for AD gives symptomatic relief and, thus, urges us to look alternative disease-modifying therapies based on multitarget directed approach. Looking at the remarkable progress made in peptide drug development last decade benefits associated with peptides, they offer valuable chemotypes [multitarget ligands (MTDLs)] as therapeutics. This review recapitulates developments harnessing peptides MTDLs combating by targeting multiple key pathways involved disease's progression. hold immense potential represent convincing avenue pursuit of novel While hurdles remain, ongoing research offers hope that may eventually provide approach combat AD.
Language: Английский
Citations
4
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: April 3, 2025
Neurodegenerative diseases (NDs) are intricately linked to the accumulation of various neurotoxins, mainly including toxic proteins, inflammatory mediators, excess metal ions, and viral pathogens. Biological neutralization strategies that use agents competitively bind harmful substances thus inhibit their pathogenic activity hold promise for direct removal neurotoxins but face many limitations challenges in NDs. Nanomaterials provide a potential solution neurotoxin NDs due unique physicochemical biological properties. This review summarizes recent advancements nanomaterial-based approaches NDs, highlighting diverse design principles mechanisms action. We also discuss critical role targeted delivery optimize efficiency advantages combining different or introducing other therapeutic components exert synergistic effects. Furthermore, we reveal current future research directions aimed at paving way nanomedicine development based on treatment
Language: Английский
Citations
0
Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 29
Published: Sept. 25, 2024
Increasing evidence suggests a potential role for infectious pathogens in the etiology of synucleinopathies, group age-related neurodegenerative disorders including Parkinson’s disease (PD), multiple system atrophy and dementia with Lewy bodies. In this review, we discuss link between infections synucleinopathies from historical perspective, present emerging that supports link, address current research challenges focus on neuroinflammation. Infectious can elicit neuroinflammatory response modulate genetic risk PD related synucleinopathies. The mechanisms how might be linked as well overlap immune cellular pathways affected by virulent disease-related factors are discussed. Here, an important α-synuclein against is emerging. Critical methodological knowledge gaps addressed, provide new future perspectives to these gaps. Understanding neuroinflammation influence will essential development early diagnostic tools novel therapies.
Language: Английский
Citations
3
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(6)
Published: Dec. 11, 2023
Abstract Neurodegenerative diseases (NDs) constitute a group of disorders characterized by the progressive deterioration nervous system functionality. Currently, precise etiological factors responsible for NDs remain incompletely elucidated, although it is probable that combination aging, genetic predisposition, and environmental stressors participate in this process. Accumulating evidence indicates viral infections, especially neurotropic viruses, can contribute to onset progression NDs. In review, emerging supporting association between infection summarized, how autophagy pathway mediated cause pathological aggregation cellular proteins associated with various discussed. Furthermore, autophagy‐related genes (ARGs) involved Herpes simplex virus (HSV‐1) are analyzed, whether these could link HSV‐1 Elucidating mechanisms underlying critical developing targeted therapeutic approaches prevent slow
Language: Английский
Citations
9
Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(7), P. 102462 - 102462
Published: May 31, 2024
Alzheimer's disease (AD) is a neurodegenerative disorder influenced by age, sex, genetic factors, immune alterations, and infections. Multiple lines of evidence suggest that changes in antibody response are linked to AD pathology. To elucidate the mechanisms underlying development, we investigated antibodies target autoimmune epitopes using high-resolution epitope microarrays. Our study compared two groups: individuals with (n = 19) non-demented (ND) controls 19). validate results, measured levels plasma samples from patients 96), mild cognitive impairment (MCI; n 91), ND 97). further explore invlovement EBV, performed masking immunofluorescence microscopy analysis tests induce lytic replication B95–8 cell line. In this study, analyzed epitope-specific serum AD, revealing significant disparities targeting multiple between control groups. Particularly noteworthy was down-regulation (anti-DG#29) an Epstein-Barr virus nuclear antigen 1 (EBNA1). This increased risk female (odds ratio up 6.6), but not male patients. investigation revealed associated EBV reactivation as indicated VCA IgG or IgM levels. Additionally, our data demonstrated region on EBNA1 for hidden during cells. findings potential relationship development female. Moreover, propose (DG#29) could serve valuable indicators
Language: Английский
Citations
1
Veterinary Microbiology, Journal Year: 2024, Volume and Issue: 297, P. 110216 - 110216
Published: Aug. 13, 2024
Language: Английский
Citations
1
Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(6)
Published: Sept. 26, 2024
Language: Английский
Citations
0
Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(6)
Published: Oct. 9, 2024
ABSTRACT The persistent challenge posed by viruses that infect the central nervous system lies in their sophisticated ability to evade host immune system. This review explores into complex mechanisms of evasion employed these neurotropic viruses, focussing on modulation responses, adaptive immunity, and cellular molecular strategies enable persistence. Key areas explored include viral latency reactivation, inhibition apoptosis, antigenic variation, with a detailed examination proteins interactions processes.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 203 - 213
Published: Nov. 29, 2024
Language: Английский
Citations
0