Involvement of the left uncinate fasciculus in the amyotrophic lateral sclerosis: an exploratory longitudinal multi-modal neuroimaging and neuropsychological study DOI
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 230(1)

Published: Dec. 17, 2024

Language: Английский

MRI biomarkers and neuropsychological assessments of hippocampal and parahippocampal regions affected by ALS: A systematic review DOI Creative Commons
Sana Mohammadi, Sadegh Ghaderi, Farzad Fatehi

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)

Published: Feb. 1, 2024

Amyotrophic lateral sclerosis (ALS) is a progressive motor and extra-motor neurodegenerative disease. This systematic review aimed to examine MRI biomarkers neuropsychological assessments of the hippocampal parahippocampal regions in patients with ALS.

Language: Английский

Citations

13
Quantitative susceptibility mapping in amyotrophic lateral sclerosis: automatic quantification of the magnetic susceptibility in the subcortical nuclei DOI
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: July 3, 2024

: Previous studies have suggested a link between dysregulation of cortical iron levels and neuronal loss in amyotrophic lateral sclerosis (ALS) patients. However, few reported differences quantitative susceptibility mapping (QSM) values subcortical nuclei patients with ALS healthy controls (HCs).

Language: Английский

Citations

7
Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis DOI Creative Commons
Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: June 1, 2024

Amyotrophic lateral sclerosis (ALS) causes motor neuron loss and progressive paralysis. While traditionally viewed as disease (MND), ALS also affects non-motor regions, such the hypothalamus. This study aimed to quantify hypothalamic subregion volumes in patients with versus healthy controls (HCs) examine their associations demographic clinical features.

Language: Английский

Citations

6
Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis DOI Creative Commons
Harold H G Tan, Abram D. Nitert, Kevin van Veenhuijzen

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 45, P. 103749 - 103749

Published: Jan. 1, 2025

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with frequent extra-motor involvement. In the present study, we investigated whether specific cognitive and behavioral deficits in ALS correlate distinct neurodegeneration patterns on brain MRI. We performed multimodal MRI Edinburgh screen (ECAS) 293 patients 237 controls. Follow-up data were acquired from 171 median duration of 7.9 months. Domain-level scores ECAS compared grey white matter parameters. Interaction analyses between controls to explore correlates ALS, rather than related normal aging. used assess changes domain-associated structures over time. Language impairment was significantly associated (left predominant) frontal, temporal, parietal subcortical neurodegeneration. Letter fluency widespread cortical Memory dysfunction hippocampal medial-temporal atrophy. Executive exclusively correlated impairment. Visuospatial did not showed that most ECAS-MRI correlations stronger (75.7% significant matter, 52.7% matter). Longitudinal all domains worsened time while, for this study population, domain decline significantly. can capture heterogeneity involvement provides useful longitudinal biomarker progression

Language: Английский

Citations

0
White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients DOI
Jiahui Tang, Yali Zhao, Yú Chen

et al.

Brain Imaging and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

Citations

0
Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia DOI Creative Commons

Huixian Lu,

Caixia Xu, Jiaquan Liang

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: April 17, 2025

Alzheimer's disease (AD) is a major cause of dementia, marked by cognitive decline and behavioral psychological symptoms dementia (BPSD). Early differentiation between AD, mild impairment (MCI), healthy controls (HC) essential for improving diagnostic accuracy guiding effective treatment strategies. This retrospective study included 120 participants divided into AD (n = 40), MCI HC 40) groups. Brain MRI data were analyzed using the AccuBrain system to quantify Resemblance Atrophy Index (AD-RAI), Quantitative Medial Temporal (QMTA), hippocampal volume, white matter hyperintensities. Correlation analyses conducted imaging biomarkers function scores (Mini-Mental State Examination, MMSE; Neuropsychiatric Inventory, NPI). Receiver operating characteristic (ROC) curve analysis was used evaluated performance biomarkers. patients had significantly higher AD-RAI (0.91 ± 0.25) more pronounced atrophy (0.36 0.09) compared (P < 0.001). showed that QMTA negatively correlated with MMSE (r -0.718, P 0.001; r -0.463, 0.001), while volume positively 0.408, ROC revealed an AUC 0.777 distinguishing from MCI, 0.938 HC. BPSD exhibited (1.09 0.18) greater atrophy, > 0.9 non-BPSD patients. The demonstrated high sensitivity value in HC, as well identifying BPSD. support use these early diagnosis personalized strategies AD.

Language: Английский

Citations

0
Diffusion tensor imaging biomarkers and clinical assessments in ALS patients: An exploratory study DOI Open Access
Saharnaz Pezeshgi, Sadegh Ghaderi, Sana Mohammadi

et al.

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Biomarkers are needed to improve diagnosis, gauge progression, evaluate treatment. Diffusion tensor imaging (DTI) promising biomarker for detecting microstructural alterations in the white matter tracts. This study aimed assess DTI metrics as biomarkers examine their relationship with clinical assessments patients ALS. Eleven ALS 21 healthy controls (HCs) underwent 3T MRI DTI. metrics, including fractional anisotropy (FA), mean diffusivity (MD), radial (RD), axial (AD), were compared between key extra-motor tract groups. Group comparisons correlations also correlated scores disability (ALSFRS-R), muscle strength (dynamometry), unit (MUNIX). Widespread differences found HCs decreased FA increased metrics. However, MD RD more sensitive changes Significant interhemispheric observed. showed symmetry hemispheres assessments. MD, RD, AD increases significantly ALSFRS-R MUNIX weaker dynamometry results. reveals damage along regions patients. can serve quantitative neuroimaging prognosis, monitoring Combined analysis imaging, electrodiagnostic, functional shows potential characterizing pathophysiology progression.

Language: Английский

Citations

1
Neural Correlates of Basketball Proficiency: An MRI Study across Skill Levels DOI Creative Commons
Manqi Zhang, Wenbiao Zhang,

Yujie Yao

et al.

Journal of Exercise Science & Fitness, Journal Year: 2024, Volume and Issue: 23(1), P. 14 - 20

Published: Dec. 6, 2024

Basketball is an attractive sport required both cooperative and antagonistic motor skills. However, the neural mechanism of basketball proficiency remains unclear. This study aimed to examine brain functional structural substrates underlying varying levels capacity.

Language: Английский

Citations

1
Evaluating the bi-directional causal association between temporomandibular disorders and neurodegenerative diseases: a two-sample Mendelian randomisation study DOI Creative Commons
Xin Huang, Jianing Li, Rui Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 26, 2024

Abstract Background Previous observational studies suggested that temporomandibular disorders (TMD) are associated with neurodegenerative diseases (NDs). This association may be mediated by confounding factors or reverse causation. Therefore, the objective of this study was to test causal relationship between TMD and four most common NDs [Alzheimer's disease (AD), Parkinson's (PD), Amyotrophic Lateral Sclerosis (ALS) Multiple (MS)]. Methods Data on (N = 134,280), AD 63,926), PD 482,730), ALS 80,610), MS 115,803) were extracted from publicly available Genome-Wide Association Studies (GWAS). Single-nucleotide polymorphisms (SNPs) used as instrumental variables (IVs) screened setting strength eliminating linkage disequilibrium. Inverse-variance weighting (IVW) method employed primary analytical approach. However, weighted median, Mendelian randomization-Egger, simple modes complementary analysis methods evaluate effects. Tests for heterogeneity pleiotropy also performed. The results' stability assessed using a leave-one-out analysis. Results Our findings revealed significant positive genetic correlations (odds ratio 1.223, 95% confidence interval 1.064–1.406, P 0.005). There no AD, ALS, MS. In randomisation, results supported effect (all > 0.05). analyses did not reveal any evidence horizontal pleiotropy. Conclusions These supply potential PD, emphasising importance effectively managing prevent PD. it is imperative conduct comprehensive validate elucidate underlying mechanisms association.

Language: Английский

Citations

0
Diffusion Tensor Imaging (DTI) Biomarker Alterations in Brain Metastases and Comparable Tumors: A Systematic Review of DTI and Tractography Findings DOI
Sadegh Ghaderi, Sana Mohammadi, Farzad Fatehi

et al.

World Neurosurgery, Journal Year: 2024, Volume and Issue: 190, P. 113 - 129

Published: July 9, 2024

Language: Английский

Citations

0