Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Aims The hippocampus has been reported to be morphologically and neurochemically altered in schizophrenia (SZ). Hyperlocomotion is a characteristic SZ‐associated behavioral phenotype, which associated with dysregulated dopamine system function induced by hippocampal hyperactivity. However, the neural mechanism of underlying hyperlocomotion remains largely unclear. Methods Mouse pups were injected N ‐methyl‐ D ‐aspartate receptor antagonist (MK‐801) or vehicle twice daily on postnatal days (PND) 7–11. In adulthood phase, one cohort mice underwent electrode implantation field CA1 for recording local potentials spike activity. A separate surgery allow calcium imaging while monitoring locomotion. Lastly, effects atypical antipsychotic (aripiprazole, ARI) evaluated Results We found that theta oscillations enhanced MK‐801‐treated mice, but correlation coefficient between spiking activity oscillation was reduced. Consistently, although rate amplitude transients neurons increased, their synchrony locomotion speed disrupted. ARI ameliorated perturbations produced MK‐801 treatment. Conclusions These results suggest disruption coordination may underly neuropathological SZ.

Language: Английский

Lack of Efficacy of Simvastatin Adjunctive Therapy for Patients with Schizophrenia: A Meta-Analysis of Randomized Controlled Trials

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1667 - 1675

Published: Sept. 1, 2024

The adjunctive therapeutic potential of simvastatin in schizophrenia treatment has generated interest due to its anti-inflammatory and neuroprotective properties. This meta-analysis aims assess the efficacy as an adjunct for schizophrenia, synthesizing results from various controlled trials.

Language: Английский