Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation DOI Creative Commons
Lorenzo Barba, Christoph Vollmuth, Steffen Halbgebauer

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 32(1)

Published: Dec. 23, 2024

Abstract Background We aimed to investigate the prognostic role of β‐synuclein in comparison that neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS). Methods measured serum concentrations β‐synuclein, NfL GFAP 24 h hospital admission 213 consecutive patients with moderate‐to‐severe AIS. investigated association between biomarkers radiological/clinical characteristics, 3‐months mortality on modified Rankin Scale (mRS). Results In AIS [mean age: 76.1 (±12.5) years, 53.1% males, median NIHSS score admission: 13 (IQR: 9–17)], higher levels were associated scores lower Alberta Stroke Program CT Score (ASPECTS) points admission. Serum was significantly correlated (rho = 0.715, p < 0.001) 0.684, 0.001). The inclusion improved accuracy prediction models without overall (AUC: 0.836 vs. 0.752, mRS 3–6 0–2 0.812 0.624, Combination and/or showed a similar accuracy. Conclusions may be used assess synaptic damage/dysfunction predict clinical outcomes

Language: Английский

The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline DOI Open Access

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

et al.

Published: Aug. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

Citations

15
Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms DOI Creative Commons
Chuan Li, Min Jiang,

Zhi‐Ting Fang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Stroke is an acute cerebrovascular disease in which brain tissue damaged due to sudden obstruction of blood flow the or rupture vessels brain, can prompt ischemic hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration components into parenchyma, and lysed cell fragments, among other factors, invariably increase blood-brain barrier (BBB) permeability, inflammatory response, edema. These changes lead neuronal death synaptic dysfunction, latter poses a significant challenge treatment.

Language: Английский

Citations

9
Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions DOI Creative Commons

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096

Published: Sept. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

Citations

6
ATP11C as a key regulator of neuronal loss following intracerebral hemorrhage in mice DOI
Peng Lü, Zilan Wang, Qing Sun

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151531 - 151531

Published: March 5, 2025

Language: Английский

Citations

0
Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice DOI Creative Commons
Jun Wang, Yulong Li, Chunyu Tan

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1167 - 1189

Published: Jan. 1, 2025

Neuroinflammatory reactions are crucial factors in secondary brain damage following intracerebral hemorrhage (ICH). Although previous studies have shown that IRAK3 is involved immune responses, the potential effects of on ICH remain unclear. Collagenase IV-induced mouse model. Western blotting was used to determine expression at different time points ICH. Immunofluorescence investigate cellular localization IRAK3. The model treated with recombinant human (rh-IRAK3) or siRNA via an intracerebroventricular injection. effect mice assessed by and short-term long-term neurological function evaluation. RNA-seq performed explore mechanism which promotes inflammation after mechanisms neuroinflammation will be further investigated blotting, qRT-PCR immunofluorescence. Recombinant IL-17A connection between NF-κB/IL-17A signaling pathway vivo vitro experiments. increased, peaking 24 h, followed a subsequent decrease mainly expressed microglia. analysis revealed 1,797 differentially genes around perihematomal tissue treatment, multiple inflammatory pathways being downregulated. Rh-IRAK3 treatment resulted upregulation levels cytokines exacerbated deficits. Furthermore, markedly decreased microglial activation pathway. response vitro; however, knockdown reversed this process. aggravates activating pathway, thereby exacerbating deficits Therefore, inhibition may promising approach for treating

Language: Английский

Citations

0
Advancements in the investigation of gut microbiota-based strategies for stroke prevention and treatment DOI Creative Commons
Min Wang, Yan Liu, Li Zhong

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Stroke represents a predominant cause of mortality and disability on global scale, impacting millions annually exerting considerable strain healthcare systems. The incidence stroke exhibits regional variability, with ischemic accounting for the majority occurrences. Post-stroke complications, such as cognitive impairment, motor dysfunction, recurrent stroke, profoundly affect patients’ quality life. Recent advancements have elucidated microbiota-gut-brain axis (MGBA), underscoring complex interplay between gut health brain function. Dysbiosis, characterized by an imbalance in microbiota, is significantly linked to elevated risk unfavorable outcomes. MGBA plays crucial role modulating immune function, neurotransmitter levels, metabolic byproducts, which may intensify neuroinflammation impair cerebral health. This review elucidates pathophysiology explores potential gut-targeted therapeutic strategies reduce promote recovery, including probiotics, prebiotics, pharmacological interventions, dietary modifications. However, current prevention treatment based intestinal flora still face many problems, large difference individual flora, stability efficacy, long-term safety need be considered. Further research needs strengthened its better application clinical practice.

Language: Английский

Citations

0
Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway DOI Creative Commons
Linlin Li,

Yujia Yuan,

Cong Zhang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Angiogenesis facilitates the reinstatement of blood supply to cerebral tissues after stroke by reconstructing vascular network, thereby rescuing penumbra region and restoring neural functions. Melatonin can modulate angiogenesis under a variety biological disease-related states, bone morphogenetic protein 6 (BMP6) targets regulators associated with angiogenesis. The specific functions melatonin BMP6 in following infarction, along potential intrinsic regulatory interactions between them, are currently unclear need further investigation. was given mice from 1st day through 28th post permanent distal middle artery occlusion (dMCAO). Our research revealed that enhanced neurological performance decreased size brain infarction. Additionally, it boosted circulation fostered area. Meanwhile, facilitated endothelial cells migration tube formation oxygen-glucose deprivation (OGD). promoted expression its downstream targets, Smad1/5/9, as well factors Vascular Endothelial Growth Factor (VEGF) Angiopoietin-1 (Ang1) vivo vitro, which counteracted or partially inhibited suppression expression. provides strong evidence promotes infarction BMP6/Smad1/5/9 signaling pathway, supporting restoration function.

Language: Английский

Citations

0
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity DOI Creative Commons

Adriana Casillas Martinez,

Leigh E. Wicki‐Stordeur, Annika V. Ariano

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract Pannexin 1 (PANX1) is an ion and metabolite membrane channel scaffold protein enriched in synaptic compartments of neurons the central nervous system. In addition to a well‐established link between PANX1 plasticity, we recently identified role for regulation dendritic spine stability. Notably, its interacting proteins are linked neurological conditions involving loss. Understanding dual function morphology may help shed light on these links. We explore potential mechanisms, including PANX1's interactions with postsynaptic receptors cytoskeleton regulating proteins. Finally, contextualize within diseases synapse dysfunction. image

Language: Английский

Citations

1
Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation DOI Creative Commons
Lorenzo Barba, Christoph Vollmuth, Steffen Halbgebauer

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 32(1)

Published: Dec. 23, 2024

Abstract Background We aimed to investigate the prognostic role of β‐synuclein in comparison that neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS). Methods measured serum concentrations β‐synuclein, NfL GFAP 24 h hospital admission 213 consecutive patients with moderate‐to‐severe AIS. investigated association between biomarkers radiological/clinical characteristics, 3‐months mortality on modified Rankin Scale (mRS). Results In AIS [mean age: 76.1 (±12.5) years, 53.1% males, median NIHSS score admission: 13 (IQR: 9–17)], higher levels were associated scores lower Alberta Stroke Program CT Score (ASPECTS) points admission. Serum was significantly correlated (rho = 0.715, p < 0.001) 0.684, 0.001). The inclusion improved accuracy prediction models without overall (AUC: 0.836 vs. 0.752, mRS 3–6 0–2 0.812 0.624, Combination and/or showed a similar accuracy. Conclusions may be used assess synaptic damage/dysfunction predict clinical outcomes

Language: Английский

Citations

0