Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 28, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
age-related
neurodegenerative
after
Alzheimer's
disease.
Despite
numerous
studies,
specific
factors
remain
unidentified.
This
study
employed
a
multi-omics
approach
to
investigate
link
between
PD
and
aging.
We
integrated
blood
gene
expression
profiles,
quantitative
trait
loci,
genome-wide
association
predictive
models,
conducted
clinical
validation.By
analyzing
datasets,
total
of
953
differentially
expressed
genes
(DEGs)
10
intersecting
aging
(ADEGs)
were
identified.
Enrichment
analysis
revealed
that
regulatory
pathways
these
ADEGs
involve
classical
Wnt
signaling
pathway,
endoplasmic
reticulum
stress,
neuronal
apoptosis.
Mendelian
randomization
(MR)
showed
MAP3K5
significantly
reduces
risk
PD.
Multivariate
regression
identified
MXD1,
CREB1,
SIRT3
as
key
diagnostic
constructed
model
aid
decision-making.
Enzyme-linked
immunosorbent
assay
experiments
validated
levels
in
serum
patients.This
utilized
identify
their
mechanisms
PD,
leading
establishment
model.
The
resource
accessible
at
this
link:
https://yunhaihupo.shinyapps.io/DynNomapp
.
web
application
can
be
used
standalone
explore
changes
transcription
profiles
relationship
aspects,
generating
new
research
hypotheses.
Epigenomics,
Journal Year:
2024,
Volume and Issue:
16(23-24), P. 1453 - 1464
Published: Nov. 27, 2024
Neurofibromatosis
(NF)
is
identified
as
genetic
disorder
characterized
by
multiple
tumors
on
nerve
tissues.
NF1
the
most
prevalent
form,
neurofibromas
and
skin
changes.
neurofibromatosis
disorder,
distinct
from
rarer
NF2
schwannomatosis
(SWN)
conditions.
NF2,
including
NF2-related
SWN
(NF2-SWN),
predominantly
involves
schwannoma
formation
differs
Current Drug Targets,
Journal Year:
2024,
Volume and Issue:
25(13), P. 866 - 884
Published: Sept. 2, 2024
An
aneurysm
is
an
abnormal
enlargement
or
bulging
of
the
wall
a
blood
vessel.
Most
often,
aneurysms
occur
in
large
vessels
-
aorta
(Thoracic
Aortic
Aneurysm
(TAA)
and
Abdominal
(AAA)
brain
(Intracranial
(IA)).
Despite
presence
significant
differences
pathogenesis
development
progression
IA
TAA/AAA,
there
are
also
similarities.
For
instance,
both
have
been
shown
to
be
strongly
influenced
by
shear
stress,
inflammatory
processes,
enzymatic
destruction
elastic
lamellae
extracellular
matrix
(ECM)
proteins
vascular
wall.
Moreover,
although
TAA
predominantly
considered
arteriopathies
with
different
pathological
mechanisms,
they
share
risk
factors
AAA,
such
as
hypertension
smoking.
However,
need
for
more
in-
-depth
study
key
elements
that
may
influence
formation
particular
find
ways
therapeutic
intervention
search
diagnostic
tool.
Today,
it
known
disruption
gene
expression
one
main
mechanisms
contribute
aneurysms.
At
same
time,
growing
evidence
suggests
aberrant
epigenetic
regulation
function
related
genesis
Although
much
has
studied
protein-coding
genes,
circular
RNAs
(circRNAs),
relatively
new
rapidly
evolving
family
transcripts,
recently
received
scientific
attention.
CircRNAs
regulate
through
sponging
microRNAs
(miRNAs)
can
used
targets
biomarkers.
Increasing
implicated
circRNAs
multiple
cardiovascular
diseases,
including
mechanism
dysregulation
certain
remains
studied.
The
discovery
advanced
our
understanding
latest
mode
miRNAs/target
genes
TAA/AAA.
aim
this
compare
profiles
similar
effects
on
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9601 - 9601
Published: Sept. 4, 2024
Cytopathology
induced
by
methamphetamine
(METH)
is
reminiscent
of
degenerative
disorders
such
as
Parkinson’s
disease,
and
it
characterized
membrane
organelles
arranged
in
tubulo-vesicular
structures.
These
areas,
appearing
clusters
vesicles,
have
never
been
defined
concerning
the
presence
specific
organelles.
Therefore,
present
study
aimed
to
identify
relative
absolute
area
membrane-bound
following
a
moderate
dose
(100
µM)
METH
administered
catecholamine-containing
PC12
cells.
Organelles
antigens
were
detected
immunofluorescence,
they
further
quantified
plain
electron
microscopy
situ
stoichiometry.
This
analysis
indicated
an
increase
autophagosomes
damaged
mitochondria
along
with
decrease
lysosomes
healthy
mitochondria.
Following
METH,
severe
dissipation
hallmark
proteins
from
their
own
vesicles
was
measured.
In
fact,
amounts
LC3
p62
reduced
within
autophagy
vacuoles
compared
whole
cytosol.
Similarly,
LAMP1
Cathepsin-D
reduced.
findings
suggest
loss
compartmentalization
confirm
competence
cell
clearing
during
catecholamine
degeneration.
Such
entropy
consistent
energy
stores,
which
routinely
govern
appropriate
subcellular
compartmentalization.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 28, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
age-related
neurodegenerative
after
Alzheimer's
disease.
Despite
numerous
studies,
specific
factors
remain
unidentified.
This
study
employed
a
multi-omics
approach
to
investigate
link
between
PD
and
aging.
We
integrated
blood
gene
expression
profiles,
quantitative
trait
loci,
genome-wide
association
predictive
models,
conducted
clinical
validation.By
analyzing
datasets,
total
of
953
differentially
expressed
genes
(DEGs)
10
intersecting
aging
(ADEGs)
were
identified.
Enrichment
analysis
revealed
that
regulatory
pathways
these
ADEGs
involve
classical
Wnt
signaling
pathway,
endoplasmic
reticulum
stress,
neuronal
apoptosis.
Mendelian
randomization
(MR)
showed
MAP3K5
significantly
reduces
risk
PD.
Multivariate
regression
identified
MXD1,
CREB1,
SIRT3
as
key
diagnostic
constructed
model
aid
decision-making.
Enzyme-linked
immunosorbent
assay
experiments
validated
levels
in
serum
patients.This
utilized
identify
their
mechanisms
PD,
leading
establishment
model.
The
resource
accessible
at
this
link:
https://yunhaihupo.shinyapps.io/DynNomapp
.
web
application
can
be
used
standalone
explore
changes
transcription
profiles
relationship
aspects,
generating
new
research
hypotheses.
