Comprehensive and high-coverage glycerophospholipidomic analysis based on iterative quadrupole time-of-flight mass spectrometry and its application in cerebral ischemia–reperfusion injury

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Mechanisms and Implications of Mitochondrial Autophagy in Stroke

Published: Jan. 1, 2024

Stroke is an acute cerebrovascular disease that caused by disruptions in the cerebral blood supply and leads to brain tissue damage. Its pathological mechanisms remain be fully elucidated. has high incidence, disability, mortality rates, thus substantially affecting life health. Against this backdrop, intracellular mitochondria, which are central cellular energy metabolism crucial for cell survival, have major roles ischemic stroke. Ischemic stroke results oxygen nutrient deprivation, thereby triggering oxidative stress inflammatory reactions, impairing mitochondrial function, disrupting metabolism. Mitochondrial autophagy a protective mechanism improve quality quantity of mitrochondria, exerts neuroprotective effects. In recent years, preserving function after emerged as research topic. Increasing evidence suggests close relationship between abnormal occurrence, progression, pathophysiology However, current not adequately explained how regulates initiation execution autophagy. Elucidating detail will critical understanding development injury, identifying novel effective intervention strategies. Additionally, optimal treatment time window must determined enable interventions minimize To deepen autophagy, review summarizes autophagy’s signaling pathways its role pathophysiology. Further exploration field provide theoretical foundation developing therapeutic strategies clinical applications.

Language: Английский

Exposure to titanium dioxide nanoparticles disrupts the BTB by interfering with the assembly of stress granules in germ cells

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 373, P. 123799 - 123799

Published: Dec. 21, 2024