The role of long non-coding RNAs in angiogenesis in ischemic stroke: new perspectives based on advanced techniques in neuroscience

Advanced technology in neuroscience ., Journal Year: 2025, Volume and Issue: 2(2), P. 77 - 84

Published: April 8, 2025

Ischemic stroke is a leading cause of long-term disability and death, making it crucial to understand the underlying cellular molecular mechanisms. Research into these mechanisms has gained significant attention, with particular focus on long noncoding RNAs, which are greater than 200 nucleotides in length. Recent studies using RNA sequencing, deep microarrays have identified numerous non-coding RNAs that aberrantly expressed both patients ischemic animal models injury. In recent years, research various types exhibit vascular protective effects harmful effects, related regulation regeneration nervous system. These findings offer new targets for study stroke. The purpose this review summarize current progress role angiogenesis after explore their potential clinical significance technologies. With advances technologies, such as sequencing researchers can gain deeper insights functions RNAs. application technologies not only enhanced understanding but also opened up possibilities development therapeutic strategies. This highlights critical roles MALAT1, XIST, MEG3 discusses how they participate process through different provide treatment pave way future research. As technological advancements emerge, there hope stroke, could assist more precise tools diagnosis treatment. Although still challenges overcome, prospects encouraging, anticipated play management

Language: Английский

Long noncoding RNA H19 knockdown promotes angiogenesis via IMP2 after ischemic stroke

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(8)

Published: Aug. 1, 2024

This study aimed to explore the effects of long noncoding RNA (lncRNA) H19 knockdown on angiogenesis and blood-brain barrier (BBB) integrity following cerebral ischemia/reperfusion (I/R) elucidate their underlying regulatory mechanisms.

Language: Английский

Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood–brain barrier integrity following rtPA reperfusion after MCAO in mice

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский