Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Feb. 6, 2025

Abstract Type 2 diabetes mellitus (T2DM) has rapidly increased worldwide, emerging as the fifth leading cause of death. The treatment T2DM is challenging due to side effects oral hypoglycemic drugs and limited efficacy long-term insulin therapy, which can lead resistance (IR). Consequently, there significant in discovering new that have minimal a pronounced effect. In obesity, microRNA levels been implicated glucose metabolism disorders T2DM, although many aspects remain unresolved. Here, we confirmed visceral adipose tissue serum microRNA-450a-5p content under obesity it was significantly positively associated with fasting blood glucose, triglycerides, cholesterol, low-density lipoproteins-cholesterol subjects. high-fat diet (HFD)-induced obese mice, expression serum, liver, white tissue. Moreover, Dicer -knockout mouse model constructed identify main source microRNA-450a-5p. could inactivate signal pathway by targeting inhibited Dual Specificity Phosphatase 10 (DUSP10) inducing IR vitro cultured hepatocytes adipocytes. Additionally, found regulate DUSP10 signaling activity, influencing tolerance sensitivity across various models, including normal diet, HFD-induced obese, tissue-specific microRNA-450a-5p-knockout, db/db mice. Furthermore, gallic acid might play potential role inhibiting decreasing expression. Thus, emerges an attractive therapeutic target for addressing IR, T2DM.

Language: Английский

Role of manganese in brain health and disease: focus on oxidative stress

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson’s disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3β/CREB/BDNF and Apoptotic Pathways

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118011 - 118011

Published: March 31, 2025

Language: Английский