Role of circadian clock in female embryo implantation DOI Creative Commons

Yukai Zhou,

Xin-Ru He,

Zhenxin Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: June 4, 2025

Accumulating evidence indicates that circadian rhythm disruption can exert an impact on female reproductive function. In the context of reproduction, success embryo implantation is utmost significance as it essential process for reproduction. Studies have demonstrated females with disrupted rhythms are more likely to experience failure, which exemplified by shift workers, nurses, and flight attendants. Therefore, comprehending crucial human Herein, we emphasize mechanism operation its regulatory effect hormones related implantation. More importantly, role peripheral clock genes in (endometrial receptivity decidualization) highlighted. Finally, melatonin hypothesized be a promising treatment failure caused disturbances.

Language: Английский

Chaihuang Qingfu Pills Protect Against Acute Pancreatitis—Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway DOI Creative Commons
Wen Xiao, Huiying Shi, Yuan Tian

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2317 - 2338

Published: Feb. 1, 2025

Severe acute pancreatitis associated with lung injury (SAP-ALI) is a critical condition high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating (AP). However, its role in underlying mechanisms remain unclear. 92 AP patients were enrolled to observe protective effect CHQF on AP-ALI. L-arginine was used establish animal model. UHPLC-MS/MS identify components absorbed into serum. Transcriptomics analysis, network pharmacology, proteomics approaches explore molecular mechanism. In vivo vitro experiments conducted validate relevant findings. Clinical data indicated reduced incidence ALI 58.33% 36.36% patients. Animal demonstrated that decreased mortality, attenuated organ damage, inhibited systemic inflammation pathological SAP mice. Differential expression analysis weighted gene co-expression (WGCNA) identified 146 SAP-related differentially expressed genes (DEGs) GSE194331 dataset. acquired 26 blood 271 therapeutic targets. Integrated obtained 52 core targets SAP. Proteomic 216 proteins treatment SAP-ALI. Joint found MMP9 NLRP3 only common Both confirmed levels pyroptosis alveolar macrophages (AMs) under conditions. Moreover, inhibitor suppressed AMs pyroptosis. exerted by inhibiting macrophage through MMP9-NLRP3 pathway, providing novel strategy

Language: Английский

Citations

1
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation DOI
Huajing Yuan,

Quancheng Han,

Hui Yu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177621 - 177621

Published: April 1, 2025

Language: Английский

Citations

0
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway DOI Creative Commons

Xinwei Zhang,

Tao Liu,

Ziqian Ma

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 12, 2025

Spinal cord injury (SCI) remains a devastating central nervous system disorder. The complex pathological microenvironment following SCI, particularly the imbalance in neuroinflammation, contributes to its therapeutic challenges. Microglial pyroptosis, type of programmed cell death, is pivotal exacerbating neuroinflammation and secondary tissue damage after SCI. Our previous study demonstrated inhibitory efficacy conditioned medium (CM) derived from human dental pulp stem cells (DPSCs) on microglial pyroptosis positive effects functional recovery SCI models. However, major secretory product CM responsible for inhibiting unclear. We aim investigate whether vascular endothelial growth factor (VEGF) secreted by DPSCs can alleviate through PI3K/AKT signaling pathway promote motor electrophysiological function mice. Human were isolated cultured, was collected VEGF detection further treatment. BV2 line established as model administration lipopolysaccharide (LPS). induced Molecular histological techniques employed evaluate explore underlying mechanisms both vivo vitro. DPSC-derived significantly inhibited vitro vivo, evidenced decreased expression pyroptosis-related markers, such caspase-1 IL-1β. anti-pyroptotic closely associated with activation pathway, which identified key regulatory mechanism. Importantly, treatment DPSC-CM improved conduction alleviates via thereby contributing repair provides new insights into potential therapy their factors, VEGF, offering perspectives

Language: Английский

Citations

0
Role of circadian clock in female embryo implantation DOI Creative Commons

Yukai Zhou,

Xin-Ru He,

Zhenxin Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: June 4, 2025

Accumulating evidence indicates that circadian rhythm disruption can exert an impact on female reproductive function. In the context of reproduction, success embryo implantation is utmost significance as it essential process for reproduction. Studies have demonstrated females with disrupted rhythms are more likely to experience failure, which exemplified by shift workers, nurses, and flight attendants. Therefore, comprehending crucial human Herein, we emphasize mechanism operation its regulatory effect hormones related implantation. More importantly, role peripheral clock genes in (endometrial receptivity decidualization) highlighted. Finally, melatonin hypothesized be a promising treatment failure caused disturbances.

Language: Английский

Citations

0